Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis

Antonino Perino, Gloria Calagna, Stefano Palomba, Biagio Adile, Salvatore Polito, Patrizia Speciale, Roberta Granese, Giorgio Gugliotta, Salvatore Saitta, Giorgio Adile, Salvatore Polito

Risultato della ricerca: Article

10 Citazioni (Scopus)

Abstract

Objective: Urinary tract infections (UTIs) are common in the female population and, over a lifetime, about half of women have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent bacterial cystitis: intravesical instilla- tion of hyaluronic acid (HA) plus chondroitin sulfate (CS), and antibiotic prophylaxis with sulfameth- oxazole plus trimethoprim.Materials and methods: This was a retrospective review of two different cohorts of women affected by recurrent bacterial cystitis. Cases (experimental group) were women who received intravesical in- stillations of a sterile solution of high concentration of HA þ CS in 50 mL water with calcium chloride every week during the 1st month and then once monthly for 4 months. The control group included women who received traditional therapy for recurrent cystitis based on daily antibiotic prophylaxis using sulfamethoxazole 200 mg plus trimethoprim 40 mg for 6 weeks.Results: Ninety-eight and 76 patients were treated with experimental and control treatments, respec- tively. At 12 months after treatment, 69 and 109 UTIs were detected in the experimental and control groups, respectively. The proportion of patients free from UTIs was significantly higher in the experi- mental than in the control group (36.7% vs. 21.0%; p 1⁄4 0.03). Experimental treatment was well tolerated and none of the patients stopped it.Conclusion: The intravesical instillation of HA þ CS is more effective than long-term antibiotic prophy- laxis for preventing recurrent bacterial cystitis.
Lingua originaleEnglish
pagine (da-a)537-540
Numero di pagine4
RivistaTaiwanese Journal of Obstetrics and Gynecology
Volume54
Stato di pubblicazionePublished - 2015

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Intravesical Administration
Cystitis
Chondroitin Sulfates
Hyaluronic Acid
Urinary Tract Infections
Antibiotic Prophylaxis
Sulfamethoxazole
Trimethoprim
Control Groups
Therapeutics
Calcium Chloride
Anti-Bacterial Agents
Water
Population

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cita questo

Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis. / Perino, Antonino; Calagna, Gloria; Palomba, Stefano; Adile, Biagio; Polito, Salvatore; Speciale, Patrizia; Granese, Roberta; Gugliotta, Giorgio; Saitta, Salvatore; Adile, Giorgio; Polito, Salvatore.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 54, 2015, pag. 537-540.

Risultato della ricerca: Article

Perino, Antonino ; Calagna, Gloria ; Palomba, Stefano ; Adile, Biagio ; Polito, Salvatore ; Speciale, Patrizia ; Granese, Roberta ; Gugliotta, Giorgio ; Saitta, Salvatore ; Adile, Giorgio ; Polito, Salvatore. / Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis. In: Taiwanese Journal of Obstetrics and Gynecology. 2015 ; Vol. 54. pagg. 537-540.
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title = "Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis",
abstract = "Objective: Urinary tract infections (UTIs) are common in the female population and, over a lifetime, about half of women have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent bacterial cystitis: intravesical instilla- tion of hyaluronic acid (HA) plus chondroitin sulfate (CS), and antibiotic prophylaxis with sulfameth- oxazole plus trimethoprim.Materials and methods: This was a retrospective review of two different cohorts of women affected by recurrent bacterial cystitis. Cases (experimental group) were women who received intravesical in- stillations of a sterile solution of high concentration of HA {\th} CS in 50 mL water with calcium chloride every week during the 1st month and then once monthly for 4 months. The control group included women who received traditional therapy for recurrent cystitis based on daily antibiotic prophylaxis using sulfamethoxazole 200 mg plus trimethoprim 40 mg for 6 weeks.Results: Ninety-eight and 76 patients were treated with experimental and control treatments, respec- tively. At 12 months after treatment, 69 and 109 UTIs were detected in the experimental and control groups, respectively. The proportion of patients free from UTIs was significantly higher in the experi- mental than in the control group (36.7{\%} vs. 21.0{\%}; p 1⁄4 0.03). Experimental treatment was well tolerated and none of the patients stopped it.Conclusion: The intravesical instillation of HA {\th} CS is more effective than long-term antibiotic prophy- laxis for preventing recurrent bacterial cystitis.",
author = "Antonino Perino and Gloria Calagna and Stefano Palomba and Biagio Adile and Salvatore Polito and Patrizia Speciale and Roberta Granese and Giorgio Gugliotta and Salvatore Saitta and Giorgio Adile and Salvatore Polito",
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T1 - Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis

AU - Perino, Antonino

AU - Calagna, Gloria

AU - Palomba, Stefano

AU - Adile, Biagio

AU - Polito, Salvatore

AU - Speciale, Patrizia

AU - Granese, Roberta

AU - Gugliotta, Giorgio

AU - Saitta, Salvatore

AU - Adile, Giorgio

AU - Polito, Salvatore

PY - 2015

Y1 - 2015

N2 - Objective: Urinary tract infections (UTIs) are common in the female population and, over a lifetime, about half of women have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent bacterial cystitis: intravesical instilla- tion of hyaluronic acid (HA) plus chondroitin sulfate (CS), and antibiotic prophylaxis with sulfameth- oxazole plus trimethoprim.Materials and methods: This was a retrospective review of two different cohorts of women affected by recurrent bacterial cystitis. Cases (experimental group) were women who received intravesical in- stillations of a sterile solution of high concentration of HA þ CS in 50 mL water with calcium chloride every week during the 1st month and then once monthly for 4 months. The control group included women who received traditional therapy for recurrent cystitis based on daily antibiotic prophylaxis using sulfamethoxazole 200 mg plus trimethoprim 40 mg for 6 weeks.Results: Ninety-eight and 76 patients were treated with experimental and control treatments, respec- tively. At 12 months after treatment, 69 and 109 UTIs were detected in the experimental and control groups, respectively. The proportion of patients free from UTIs was significantly higher in the experi- mental than in the control group (36.7% vs. 21.0%; p 1⁄4 0.03). Experimental treatment was well tolerated and none of the patients stopped it.Conclusion: The intravesical instillation of HA þ CS is more effective than long-term antibiotic prophy- laxis for preventing recurrent bacterial cystitis.

AB - Objective: Urinary tract infections (UTIs) are common in the female population and, over a lifetime, about half of women have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent bacterial cystitis: intravesical instilla- tion of hyaluronic acid (HA) plus chondroitin sulfate (CS), and antibiotic prophylaxis with sulfameth- oxazole plus trimethoprim.Materials and methods: This was a retrospective review of two different cohorts of women affected by recurrent bacterial cystitis. Cases (experimental group) were women who received intravesical in- stillations of a sterile solution of high concentration of HA þ CS in 50 mL water with calcium chloride every week during the 1st month and then once monthly for 4 months. The control group included women who received traditional therapy for recurrent cystitis based on daily antibiotic prophylaxis using sulfamethoxazole 200 mg plus trimethoprim 40 mg for 6 weeks.Results: Ninety-eight and 76 patients were treated with experimental and control treatments, respec- tively. At 12 months after treatment, 69 and 109 UTIs were detected in the experimental and control groups, respectively. The proportion of patients free from UTIs was significantly higher in the experi- mental than in the control group (36.7% vs. 21.0%; p 1⁄4 0.03). Experimental treatment was well tolerated and none of the patients stopped it.Conclusion: The intravesical instillation of HA þ CS is more effective than long-term antibiotic prophy- laxis for preventing recurrent bacterial cystitis.

UR - http://hdl.handle.net/10447/148859

M3 - Article

VL - 54

SP - 537

EP - 540

JO - Taiwanese Journal of Obstetrics and Gynecology

JF - Taiwanese Journal of Obstetrics and Gynecology

SN - 1028-4559

ER -