Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis

Antonino Perino, Salvatore Polito, Gloria Calagna, Giorgio Adile, Roberta Granese, Giorgio Gugliotta, Salvatore Saitta, Stefano Palomba, Giorgio Adile, Gloria Calagna, Biagio Adile, Salvatore Polito, Antonino Perino, Patrizia Speciale

Risultato della ricerca: Article

8 Citazioni (Scopus)

Abstract

Objective: Urinary tract infections (UTIs) are common in the female population and, over a lifetime, about half of women have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent bacterial cystitis: intravesical instilla- tion of hyaluronic acid (HA) plus chondroitin sulfate (CS), and antibiotic prophylaxis with sulfameth- oxazole plus trimethoprim. Materials and methods: This was a retrospective review of two different cohorts of women affected by recurrent bacterial cystitis. Cases (experimental group) were women who received intravesical in- stillations of a sterile solution of high concentration of HA þ CS in 50 mL water with calcium chloride every week during the 1st month and then once monthly for 4 months. The control group included women who received traditional therapy for recurrent cystitis based on daily antibiotic prophylaxis using sulfamethoxazole 200 mg plus trimethoprim 40 mg for 6 weeks. Results: Ninety-eight and 76 patients were treated with experimental and control treatments, respec- tively. At 12 months after treatment, 69 and 109 UTIs were detected in the experimental and control groups, respectively. The proportion of patients free from UTIs was significantly higher in the experi- mental than in the control group (36.7% vs. 21.0%; p 1⁄4 0.03). Experimental treatment was well tolerated and none of the patients stopped it. Conclusion: The intravesical instillation of HA þ CS is more effective than long-term antibiotic prophy- laxis for preventing recurrent bacterial cystitis.
Lingua originaleEnglish
pagine (da-a)537-540
Numero di pagine4
RivistaTaiwanese Journal of Obstetrics and Gynecology
Volume54
Stato di pubblicazionePublished - 2015

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Intravesical Administration
Cystitis
Chondroitin Sulfates
Hyaluronic Acid
Urinary Tract Infections
Antibiotic Prophylaxis
Sulfamethoxazole
Trimethoprim
Control Groups
Therapeutics
Calcium Chloride
Anti-Bacterial Agents
Water
Population

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cita questo

Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis. / Perino, Antonino; Polito, Salvatore; Calagna, Gloria; Adile, Giorgio; Granese, Roberta; Gugliotta, Giorgio; Saitta, Salvatore; Palomba, Stefano; Adile, Giorgio; Calagna, Gloria; Adile, Biagio; Polito, Salvatore; Perino, Antonino; Speciale, Patrizia.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 54, 2015, pag. 537-540.

Risultato della ricerca: Article

Perino, Antonino ; Polito, Salvatore ; Calagna, Gloria ; Adile, Giorgio ; Granese, Roberta ; Gugliotta, Giorgio ; Saitta, Salvatore ; Palomba, Stefano ; Adile, Giorgio ; Calagna, Gloria ; Adile, Biagio ; Polito, Salvatore ; Perino, Antonino ; Speciale, Patrizia. / Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis. In: Taiwanese Journal of Obstetrics and Gynecology. 2015 ; Vol. 54. pagg. 537-540.
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title = "Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis",
abstract = "Objective: Urinary tract infections (UTIs) are common in the female population and, over a lifetime, about half of women have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent bacterial cystitis: intravesical instilla- tion of hyaluronic acid (HA) plus chondroitin sulfate (CS), and antibiotic prophylaxis with sulfameth- oxazole plus trimethoprim. Materials and methods: This was a retrospective review of two different cohorts of women affected by recurrent bacterial cystitis. Cases (experimental group) were women who received intravesical in- stillations of a sterile solution of high concentration of HA {\th} CS in 50 mL water with calcium chloride every week during the 1st month and then once monthly for 4 months. The control group included women who received traditional therapy for recurrent cystitis based on daily antibiotic prophylaxis using sulfamethoxazole 200 mg plus trimethoprim 40 mg for 6 weeks. Results: Ninety-eight and 76 patients were treated with experimental and control treatments, respec- tively. At 12 months after treatment, 69 and 109 UTIs were detected in the experimental and control groups, respectively. The proportion of patients free from UTIs was significantly higher in the experi- mental than in the control group (36.7{\%} vs. 21.0{\%}; p 1⁄4 0.03). Experimental treatment was well tolerated and none of the patients stopped it. Conclusion: The intravesical instillation of HA {\th} CS is more effective than long-term antibiotic prophy- laxis for preventing recurrent bacterial cystitis.",
author = "Antonino Perino and Salvatore Polito and Gloria Calagna and Giorgio Adile and Roberta Granese and Giorgio Gugliotta and Salvatore Saitta and Stefano Palomba and Giorgio Adile and Gloria Calagna and Biagio Adile and Salvatore Polito and Antonino Perino and Patrizia Speciale",
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TY - JOUR

T1 - Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis

AU - Perino, Antonino

AU - Polito, Salvatore

AU - Calagna, Gloria

AU - Adile, Giorgio

AU - Granese, Roberta

AU - Gugliotta, Giorgio

AU - Saitta, Salvatore

AU - Palomba, Stefano

AU - Adile, Giorgio

AU - Calagna, Gloria

AU - Adile, Biagio

AU - Polito, Salvatore

AU - Perino, Antonino

AU - Speciale, Patrizia

PY - 2015

Y1 - 2015

N2 - Objective: Urinary tract infections (UTIs) are common in the female population and, over a lifetime, about half of women have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent bacterial cystitis: intravesical instilla- tion of hyaluronic acid (HA) plus chondroitin sulfate (CS), and antibiotic prophylaxis with sulfameth- oxazole plus trimethoprim. Materials and methods: This was a retrospective review of two different cohorts of women affected by recurrent bacterial cystitis. Cases (experimental group) were women who received intravesical in- stillations of a sterile solution of high concentration of HA þ CS in 50 mL water with calcium chloride every week during the 1st month and then once monthly for 4 months. The control group included women who received traditional therapy for recurrent cystitis based on daily antibiotic prophylaxis using sulfamethoxazole 200 mg plus trimethoprim 40 mg for 6 weeks. Results: Ninety-eight and 76 patients were treated with experimental and control treatments, respec- tively. At 12 months after treatment, 69 and 109 UTIs were detected in the experimental and control groups, respectively. The proportion of patients free from UTIs was significantly higher in the experi- mental than in the control group (36.7% vs. 21.0%; p 1⁄4 0.03). Experimental treatment was well tolerated and none of the patients stopped it. Conclusion: The intravesical instillation of HA þ CS is more effective than long-term antibiotic prophy- laxis for preventing recurrent bacterial cystitis.

AB - Objective: Urinary tract infections (UTIs) are common in the female population and, over a lifetime, about half of women have at least one episode of UTI requiring antibiotic therapy. The aim of the current study was to compare two different strategies for preventing recurrent bacterial cystitis: intravesical instilla- tion of hyaluronic acid (HA) plus chondroitin sulfate (CS), and antibiotic prophylaxis with sulfameth- oxazole plus trimethoprim. Materials and methods: This was a retrospective review of two different cohorts of women affected by recurrent bacterial cystitis. Cases (experimental group) were women who received intravesical in- stillations of a sterile solution of high concentration of HA þ CS in 50 mL water with calcium chloride every week during the 1st month and then once monthly for 4 months. The control group included women who received traditional therapy for recurrent cystitis based on daily antibiotic prophylaxis using sulfamethoxazole 200 mg plus trimethoprim 40 mg for 6 weeks. Results: Ninety-eight and 76 patients were treated with experimental and control treatments, respec- tively. At 12 months after treatment, 69 and 109 UTIs were detected in the experimental and control groups, respectively. The proportion of patients free from UTIs was significantly higher in the experi- mental than in the control group (36.7% vs. 21.0%; p 1⁄4 0.03). Experimental treatment was well tolerated and none of the patients stopped it. Conclusion: The intravesical instillation of HA þ CS is more effective than long-term antibiotic prophy- laxis for preventing recurrent bacterial cystitis.

UR - http://hdl.handle.net/10447/148859

M3 - Article

VL - 54

SP - 537

EP - 540

JO - Taiwanese Journal of Obstetrics and Gynecology

JF - Taiwanese Journal of Obstetrics and Gynecology

SN - 1028-4559

ER -