Invasive candida infections in neonates after major surgery: Current evidence and new directions

Mario Giuffre, Francesco Cavigioli, Paolo Manzoni, Alessandra Santisi, Ilaria Cocchi, Marzia Maino, Domenico Umberto De Rose, Ludovica Martini, Benedetta Della Torre, Giovanna Nardella, Danila Mazzeo, Elvira Bonanno, Cinzia Auriti, Chryssoula Tzialla, Lorenza Pugni, Andrea Dotta, Danila Mazzeo, Maria Paola Ronchetti, Pietro Bagolan, Lisa SerafiniPasqua Betta, Jenny Bua

Risultato della ricerca: Articlepeer review

Abstract

Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.
Lingua originaleEnglish
pagine (da-a)319-
Numero di pagine18
RivistaPathogens
Volume10
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1312???
  • ???subjectarea.asjc.2400.2400???
  • ???subjectarea.asjc.2700.2726???
  • ???subjectarea.asjc.2700.2725???

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