Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients from 29 Countries

Andrea Cortegiani, Massimiliano Sorbello, Konstanty Szułdrzyński, Luigi Camporota, Jean Baptiste Lascarrou, Laura Antolini, Robert Greif, John G. Laffey, Philippe Bauer, Athanasios Chalkias, Vincenzo Russotto, Kristaps Bokums, Roberto Fumagalli, David Brewster, Emanuela Rossi, Elena Tassistro, Paolo Pelosi, John G. Laffey, Robert Greif, Antonio PesentiChristina Agvald-Öhman, Giacomo Bellani, Giuseppe Foti, Antonio Pesenti, Paolo Pelosi, Christian Putensen, Sheila Nainan Myatra, Andy Higgs

Risultato della ricerca: Articlepeer review

126 Citazioni (Scopus)


Importance: Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events. Objective: To evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients. Design, Setting, and Participants: The International Observational Study to Understand the Impact and Best Practices of Airway Management in Critically Ill Patients (INTUBE) study was an international, multicenter, prospective cohort study involving consecutive critically ill patients undergoing tracheal intubation in the intensive care units (ICUs), emergency departments, and wards, from October 1, 2018, to July 31, 2019 (August 28, 2019, was the final follow-up) in a convenience sample of 197 sites from 29 countries across 5 continents. Exposures: Tracheal intubation. Main Outcomes and Measures: The primary outcome was the incidence of major adverse peri-intubation events defined as at least 1 of the following events occurring within 30 minutes from the start of the intubation procedure: cardiovascular instability (either: systolic pressure <65 mm Hg at least once, <90 mm Hg for >30 minutes, new or increase need of vasopressors or fluid bolus >15 mL/kg), severe hypoxemia (peripheral oxygen saturation <80%) or cardiac arrest. The secondary outcomes included intensive care unit mortality. Results: Of 3659 patients screened, 2964 (median age, 63 years; interquartile range [IQR], 49-74 years; 62.6% men) from 197 sites across 5 continents were included. The main reason for intubation was respiratory failure in 52.3% of patients, followed by neurological impairment in 30.5%, and cardiovascular instability in 9.4%. Primary outcome data were available for all patients. Among the study patients, 45.2% experienced at least 1 major adverse peri-intubation event. The predominant event was cardiovascular instability, observed in 42.6% of all patients undergoing emergency intubation, followed by severe hypoxemia (9.3%) and cardiac arrest (3.1%). Overall ICU mortality was 32.8%. Conclusions and Relevance: In this observational study of intubation practices in critically ill patients from a convenience sample of 197 sites across 29 countries, major adverse peri-intubation events - in particular cardiovascular instability - were observed frequently.
Lingua originaleEnglish
pagine (da-a)1164-1172
Numero di pagine9
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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