INTRABDOMINAL DESMOPLASTIC SMALL ROUND CELL TUMOR: CASE REPORT WITH LITERATURE REVIEW

Giovanni Tomasello, Iskandar Daou, Tarek Bou Assi, Tarek Bou Assi, Tarek Bou Assi, Georges Nawfal, Abdo Jurjus, Joseph Kreiker

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)

Abstract

Intra-abdominal desmoplastic small round cell tumor arerrare aggressive neoplasm, with a very poor prognosis, observed in young adults with a male predominance, Their etiology is unknown and the diagnosis is based on histopathology, immunohistochemistry and cytogenetics. Histological analysis shows typically clusters of round cells separated by abundant desmoplastic stroma. These tumors exhibit a multi-marker immunohistochemistry profile expressing the three embryonic lineages: epithelial, neural and mesenchymal. They are positive for desmin and cytokeratin and are characterized by a specific recurring translocation t (11:22) (q12-p13), which involves EWSR! WT1 gene. They are usually fatal despite an aggressive multidisciplinary therapeutic approach. Hereby we report the case of 39 yera old man who presented with an intra-abdominal desmoplastic small round cell tumor. The diagnosis was made by radiological, histological and immunohistochemistry profile analyses of a CT scanguided biopsy. This articel includes a mini review of the literature.
Lingua originaleEnglish
pagine (da-a)209-216
Numero di pagine8
RivistaEuroMediterranean Biomedical Journal
Volume10
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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