Abstract: Background: A BMI > 25 is the most decisive, albeit modifiable, risk factor for kneeosteoarthritis (KOA). This study aimed at assessing the efficacy of intra-articular injections of hybridhyaluronic acid (HA) complexes (Sinovial® H-L) for the treatment of KOA in overweight patients interms of disease severity, cardiocirculatory capacity, and quality of life. Materials: In this single-site,open-label, prospective trial, 37 patients with symptomatic knee OA were assessed at baseline and3 months after ultrasound-guided intra-articular injection of hybrid HA complexes (Sinovial® H-L).Results: Primary variables displaying a statistically significant improvement after treatment werepain (VAS), disease severity (WOMAC), and cardiopulmonary capacity (6 min walk test). Amongsecondary variables, quality of life (SF-12) improved significantly, as did analgesic intake for paincontrol. No statistically significant difference was observed in body fat and muscle mass percentagemeasured by bioelectrical impedance analysis. Conclusions: Intra-articular hybrid HA injectionsare significantly effective in improving OA-related disease severity, cardiopulmonary function, andanalgesic intake. This supports the role of hybrid HA viscosupplementation as a nonpharmacologicaltreatment to relieve pain, reduce disability, improve quality of life, and limit the risk of polypharmacyin overweight patients with knee OA.
|Numero di pagine||10|
|Stato di pubblicazione||Published - 2021|