Intra-Articular Hybrid Hyaluronic Acid Injection Treatment in Overweight Patients with Knee Osteoarthritis: A Single-Center, Open-Label, Prospective Study

Vincenzo Falco, Daniele Cuntrera, Giulia Letizia Mauro, Dalila Scaturro, Mirko Pesce, Massimiliano Mangone, Marco Invernizzi, Andrea Bernetti, Teresa Paolucci, Alessandro De Sire, Irene La Fratta, Marco Paoloni, Francesco Agostini, Antonia Patruno, Alfredo Grilli, Pietro Terrana

Risultato della ricerca: Articlepeer review

Abstract

Abstract: Background: A BMI > 25 is the most decisive, albeit modifiable, risk factor for kneeosteoarthritis (KOA). This study aimed at assessing the efficacy of intra-articular injections of hybridhyaluronic acid (HA) complexes (Sinovial® H-L) for the treatment of KOA in overweight patients interms of disease severity, cardiocirculatory capacity, and quality of life. Materials: In this single-site,open-label, prospective trial, 37 patients with symptomatic knee OA were assessed at baseline and3 months after ultrasound-guided intra-articular injection of hybrid HA complexes (Sinovial® H-L).Results: Primary variables displaying a statistically significant improvement after treatment werepain (VAS), disease severity (WOMAC), and cardiopulmonary capacity (6 min walk test). Amongsecondary variables, quality of life (SF-12) improved significantly, as did analgesic intake for paincontrol. No statistically significant difference was observed in body fat and muscle mass percentagemeasured by bioelectrical impedance analysis. Conclusions: Intra-articular hybrid HA injectionsare significantly effective in improving OA-related disease severity, cardiopulmonary function, andanalgesic intake. This supports the role of hybrid HA viscosupplementation as a nonpharmacologicaltreatment to relieve pain, reduce disability, improve quality of life, and limit the risk of polypharmacyin overweight patients with knee OA.
Lingua originaleEnglish
Numero di pagine10
RivistaAPPLIED SCIENCES
Volume11
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3100.3105???
  • ???subjectarea.asjc.2200.2200???
  • ???subjectarea.asjc.1500.1508???
  • ???subjectarea.asjc.1700.1706???
  • ???subjectarea.asjc.1500.1507???

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