Intestinal microbiota mutualism and gastrointestinal diseases

Angelo Leone, Giovanni Tomasello, Marco Giammanco, Danila Di Majo, Marie Noel Zeenny, Provvidenza Damiani, Abdo Jurjus, Giovanna Traina, Provvidenza Damiani, Marie-Noel Zeenny, Emanuele Sinagra, Emanuele Sinagra, Rosalyn Jurjus Zein

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

The purpose of this work is to investigate the link between an altered intestinal mcro-biota or dysbiosis and chronic inflammatory disorders, in particular inflammatory bowel disease (IBD). Along with probiotics, faecal microbiota transplantation (FMT) opts to be a promising therapeutic treatment for restoring the bacterial homeostasis of the hu-man intestine and reducing the risk of colorectal carcinogenesis. Microbiota is the com-plex microbial flora that resides in the gut establishing a mutually beneficial relation-ship. Alteration of the microbiota’s composition, termed as dysbiosis, may lead to pathological conditions. Treatment with probiotics can restore the normal commensal flora in IBD. Intestinal microbiota affects the circadian rhythm which in turn regulates the expression of different genes in GALT (gut associated lymphoid tissue) playing a role in the prevention of inflammation and colorectal cancer (CRC) progression. This article highlights the involvement of different microbial strains in the pathogenesis of dysbiosis and in the creation of a carcinogenic milieu caused by an altered stimulation of the immune system. Therapies targeting the equilibrium of the microbiota to switch off chronic inflammation and prevent the progression to CRC seem to be a promising therapeutic tool for a variety of inflammation-associated diseases.
Lingua originaleEnglish
pagine (da-a)65-75
Numero di pagine11
RivistaEuroMediterranean Biomedical Journal
Volume10
Stato di pubblicazionePublished - 2015

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Symbiosis
Gastrointestinal Diseases
Dysbiosis
Microbiota
Probiotics
Inflammation
Inflammatory Bowel Diseases
Colorectal Neoplasms
Therapeutics
Biota
Ships
Lymphoid Tissue
Circadian Rhythm
Intestines
Immune System
Carcinogenesis
Homeostasis
Gastrointestinal Microbiome
Gene Expression

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cita questo

Intestinal microbiota mutualism and gastrointestinal diseases. / Leone, Angelo; Tomasello, Giovanni; Giammanco, Marco; Di Majo, Danila; Zeenny, Marie Noel; Damiani, Provvidenza; Jurjus, Abdo; Traina, Giovanna; Damiani, Provvidenza; Zeenny, Marie-Noel; Sinagra, Emanuele; Sinagra, Emanuele; Zein, Rosalyn Jurjus.

In: EuroMediterranean Biomedical Journal, Vol. 10, 2015, pag. 65-75.

Risultato della ricerca: Article

Leone, A, Tomasello, G, Giammanco, M, Di Majo, D, Zeenny, MN, Damiani, P, Jurjus, A, Traina, G, Damiani, P, Zeenny, M-N, Sinagra, E, Sinagra, E & Zein, RJ 2015, 'Intestinal microbiota mutualism and gastrointestinal diseases', EuroMediterranean Biomedical Journal, vol. 10, pagg. 65-75.
Leone, Angelo ; Tomasello, Giovanni ; Giammanco, Marco ; Di Majo, Danila ; Zeenny, Marie Noel ; Damiani, Provvidenza ; Jurjus, Abdo ; Traina, Giovanna ; Damiani, Provvidenza ; Zeenny, Marie-Noel ; Sinagra, Emanuele ; Sinagra, Emanuele ; Zein, Rosalyn Jurjus. / Intestinal microbiota mutualism and gastrointestinal diseases. In: EuroMediterranean Biomedical Journal. 2015 ; Vol. 10. pagg. 65-75.
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AU - Damiani, Provvidenza

AU - Jurjus, Abdo

AU - Traina, Giovanna

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