Interleukin-9 and T helper type 9 cells in rheumatic diseases

Giuliana Guggino, Angelo Ferrante, Francesco Ciccia, Giovanni Triolo, Roberto Giacomelli, Paola Cipriani

Risultato della ricerca: Articlepeer review

27 Citazioni (Scopus)

Abstract

Interleukin (IL)-9 is a 28-30 kDa monomeric glycosylated polypeptide belonging to the IL-7/IL-9 family of proteins that bind to a composite receptor consisting of the private receptor IL-9R and the IL-2 receptor, gamma (IL-2RG), a common gamma subunit shared by the receptors of many different cytokines. The IL-9R is expressed widely and IL-9 impacts a number of effector cells, such as effector T cells, B cells, innate lymphoid cells, mast cells, polymorphonuclear cells, epithelial cells and smooth muscle cells, playing an important role in regulating inflammatory immunity. The critical role of IL-9 in promoting cellular and humoral immune responses makes it an important focus of potential therapeutic interventions. Recently, a defined subset of T helper type cells, Th9 cells, has been identified by the potent production of IL-9. The involvement of the Th9 cell subset has been described in many types of inflammatory diseases, namely atopic diseases, helminth infections, experimental autoimmune encephalomyelitis and ulcerative colitis. In this review, we summarize the IL-9 biological activities, highlighting roles for IL-9 and Th9 cells in rheumatoid and psoriatic arthritis, systemic vasculitis, systemic lupus erythematosus and systemic sclerosis.
Lingua originaleEnglish
pagine (da-a)125-132
Numero di pagine8
RivistaClinical and Experimental Immunology
Volume185
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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