Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men.

Domenico Lio, Tumini, Cecilia Tampieri, Elisa Porcellini, Martina Chiappelli, Nanni, Federico Licastro, Angelo Branzi, Claudio M. Caldarera

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    Abstract

    Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6 gene. Plasma concentrations of IL-6 and C-reactive protein (CRP) in a group of patients and controls were measured. The -174 C allele was associated with an increased risk of developing MI (OR = 2.886, c.i. = 1.801-4.624, P = 0.0001) in older patients, while no association was found in younger ones. The IL-6 plasma levels were higher in patients with MI carrying the CC genotype than in GG patients (CC carriers, IL-6 = 2.97 pg mL-1 vs. GG carriers = 1.81 pg mL-1, P = 0.016). A positive correlation of IL-6 levels with those of CRP in serum from patients with MI was also found. Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 - 174 promoter polymorphism.
    Lingua originaleEnglish
    pagine (da-a)349-353
    Numero di pagine5
    RivistaEuropean Journal of Immunogenetics
    Volume32
    Stato di pubblicazionePublished - 2005

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    All Science Journal Classification (ASJC) codes

    • Immunology
    • Molecular Biology
    • Genetics
    • Genetics(clinical)

    Cita questo

    Lio, D., Tumini, Tampieri, C., Porcellini, E., Chiappelli, M., Nanni, Licastro, F., Branzi, A., & Caldarera, C. M. (2005). Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. European Journal of Immunogenetics, 32, 349-353.