Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men.

Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F.

    Risultato della ricerca: Article

    55 Citazioni (Scopus)

    Abstract

    Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6 gene. Plasma concentrations of IL-6 and C-reactive protein (CRP) in a group of patients and controls were measured. The -174 C allele was associated with an increased risk of developing MI (OR = 2.886, c.i. = 1.801-4.624, P = 0.0001) in older patients, while no association was found in younger ones. The IL-6 plasma levels were higher in patients with MI carrying the CC genotype than in GG patients (CC carriers, IL-6 = 2.97 pg mL-1 vs. GG carriers = 1.81 pg mL-1, P = 0.016). A positive correlation of IL-6 levels with those of CRP in serum from patients with MI was also found. Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 - 174 promoter polymorphism.
    Lingua originaleEnglish
    pagine (da-a)349-353
    Numero di pagine5
    RivistaEuropean Journal of Immunogenetics
    Volume32
    Stato di pubblicazionePublished - 2005

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Genetics(clinical)
    • Genetics
    • Molecular Biology

    Cita questo

    Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F. (2005). Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. European Journal of Immunogenetics, 32, 349-353.

    Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. / Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F.

    In: European Journal of Immunogenetics, Vol. 32, 2005, pag. 349-353.

    Risultato della ricerca: Article

    Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F. 2005, 'Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men.', European Journal of Immunogenetics, vol. 32, pagg. 349-353.
    Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F. Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. European Journal of Immunogenetics. 2005;32:349-353.
    Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F. / Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. In: European Journal of Immunogenetics. 2005 ; Vol. 32. pagg. 349-353.
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    title = "Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men.",
    abstract = "Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6 gene. Plasma concentrations of IL-6 and C-reactive protein (CRP) in a group of patients and controls were measured. The -174 C allele was associated with an increased risk of developing MI (OR = 2.886, c.i. = 1.801-4.624, P = 0.0001) in older patients, while no association was found in younger ones. The IL-6 plasma levels were higher in patients with MI carrying the CC genotype than in GG patients (CC carriers, IL-6 = 2.97 pg mL-1 vs. GG carriers = 1.81 pg mL-1, P = 0.016). A positive correlation of IL-6 levels with those of CRP in serum from patients with MI was also found. Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 - 174 promoter polymorphism.",
    author = "{Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F.} and Domenico Lio",
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    AU - Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F.

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    N2 - Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6 gene. Plasma concentrations of IL-6 and C-reactive protein (CRP) in a group of patients and controls were measured. The -174 C allele was associated with an increased risk of developing MI (OR = 2.886, c.i. = 1.801-4.624, P = 0.0001) in older patients, while no association was found in younger ones. The IL-6 plasma levels were higher in patients with MI carrying the CC genotype than in GG patients (CC carriers, IL-6 = 2.97 pg mL-1 vs. GG carriers = 1.81 pg mL-1, P = 0.016). A positive correlation of IL-6 levels with those of CRP in serum from patients with MI was also found. Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 - 174 promoter polymorphism.

    AB - Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6 gene. Plasma concentrations of IL-6 and C-reactive protein (CRP) in a group of patients and controls were measured. The -174 C allele was associated with an increased risk of developing MI (OR = 2.886, c.i. = 1.801-4.624, P = 0.0001) in older patients, while no association was found in younger ones. The IL-6 plasma levels were higher in patients with MI carrying the CC genotype than in GG patients (CC carriers, IL-6 = 2.97 pg mL-1 vs. GG carriers = 1.81 pg mL-1, P = 0.016). A positive correlation of IL-6 levels with those of CRP in serum from patients with MI was also found. Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 - 174 promoter polymorphism.

    UR - http://hdl.handle.net/10447/15528

    M3 - Article

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    SP - 349

    EP - 353

    JO - International Journal of Immunogenetics

    JF - International Journal of Immunogenetics

    SN - 1744-3121

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