Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 349-353 |
| Numero di pagine | 5 |
| Rivista | European Journal of Immunogenetics |
| Volume | 32 |
| Stato di pubblicazione | Published - 2005 |
All Science Journal Classification (ASJC) codes
- Immunology
- Genetics(clinical)
- Genetics
- Molecular Biology
Cita questo
Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. / Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F.
In: European Journal of Immunogenetics, Vol. 32, 2005, pag. 349-353.Risultato della ricerca: Article
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TY - JOUR
T1 - Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men.
AU - Chiappelli, M.; Tampieri, C.; Tumini, E.; Porcellini, E.; Caldarera, C.; Nanni, S.; Branzi, A.; Caruso, M.; Hoffmann, E.; Caruso, C.; Licastro, F.
AU - Lio, Domenico
PY - 2005
Y1 - 2005
N2 - Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6 gene. Plasma concentrations of IL-6 and C-reactive protein (CRP) in a group of patients and controls were measured. The -174 C allele was associated with an increased risk of developing MI (OR = 2.886, c.i. = 1.801-4.624, P = 0.0001) in older patients, while no association was found in younger ones. The IL-6 plasma levels were higher in patients with MI carrying the CC genotype than in GG patients (CC carriers, IL-6 = 2.97 pg mL-1 vs. GG carriers = 1.81 pg mL-1, P = 0.016). A positive correlation of IL-6 levels with those of CRP in serum from patients with MI was also found. Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 - 174 promoter polymorphism.
AB - Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6 gene. Plasma concentrations of IL-6 and C-reactive protein (CRP) in a group of patients and controls were measured. The -174 C allele was associated with an increased risk of developing MI (OR = 2.886, c.i. = 1.801-4.624, P = 0.0001) in older patients, while no association was found in younger ones. The IL-6 plasma levels were higher in patients with MI carrying the CC genotype than in GG patients (CC carriers, IL-6 = 2.97 pg mL-1 vs. GG carriers = 1.81 pg mL-1, P = 0.016). A positive correlation of IL-6 levels with those of CRP in serum from patients with MI was also found. Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 - 174 promoter polymorphism.
UR - http://hdl.handle.net/10447/15528
M3 - Article
VL - 32
SP - 349
EP - 353
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
SN - 1744-3121
ER -