Interactions of tryptophan and serotonin with biomembrane models: Binding to reversed micellar systems of ionic and non ionic surfactants

Vincenzo Turco Liveri, Mirella Ferrugia, Leopoldo Ceraulo, David Bongiorno, Giuseppe Avellone, Vincenzo Turco Liveri, Mirella Ferrugia, David Bongiorno, Leopoldo Ceraulo, Giuseppe Avellone

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Abstract

The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.
Lingua originaleEnglish
pagine (da-a)254-257
Numero di pagine4
RivistaBollettino Chimico Farmaceutico
Volume140
Stato di pubblicazionePublished - 2001

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Surface-Active Agents
Tryptophan
Serotonin
Dioctyl Sulfosuccinic Acid
Water
Micelles
Spectrum Analysis

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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@article{219b395533544086a291f8a150595ebb,
title = "Interactions of tryptophan and serotonin with biomembrane models: Binding to reversed micellar systems of ionic and non ionic surfactants",
abstract = "The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.",
keywords = "Membrane models, Molecular Medicine, Reversed micelles, Serotonin, Solubilization, Tryptophan, UV-spectroscopy",
author = "{Turco Liveri}, Vincenzo and Mirella Ferrugia and Leopoldo Ceraulo and David Bongiorno and Giuseppe Avellone and {Turco Liveri}, Vincenzo and Mirella Ferrugia and David Bongiorno and Leopoldo Ceraulo and Giuseppe Avellone",
year = "2001",
language = "English",
volume = "140",
pages = "254--257",
journal = "Bollettino Chimico Farmaceutico",
issn = "0006-6648",
publisher = "Societa Editoriale Farmaceutica",

}

TY - JOUR

T1 - Interactions of tryptophan and serotonin with biomembrane models: Binding to reversed micellar systems of ionic and non ionic surfactants

AU - Turco Liveri, Vincenzo

AU - Ferrugia, Mirella

AU - Ceraulo, Leopoldo

AU - Bongiorno, David

AU - Avellone, Giuseppe

AU - Turco Liveri, Vincenzo

AU - Ferrugia, Mirella

AU - Bongiorno, David

AU - Ceraulo, Leopoldo

AU - Avellone, Giuseppe

PY - 2001

Y1 - 2001

N2 - The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.

AB - The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.

KW - Membrane models

KW - Molecular Medicine

KW - Reversed micelles

KW - Serotonin

KW - Solubilization

KW - Tryptophan

KW - UV-spectroscopy

UR - http://hdl.handle.net/10447/243609

M3 - Article

VL - 140

SP - 254

EP - 257

JO - Bollettino Chimico Farmaceutico

JF - Bollettino Chimico Farmaceutico

SN - 0006-6648

ER -