Interactions of tryptophan and serotonin with biomembrane models: Binding to reversed micellar systems of ionic and non ionic surfactants

Leopoldo Ceraulo, Mirella Ferrugia, Vincenzo Turco Liveri, David Bongiorno, Giuseppe Avellone, Mirella Ferrugia, David Bongiorno, Leopoldo Ceraulo, Giuseppe Avellone, Vincenzo Turco Liveri

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Abstract

The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.
Lingua originaleEnglish
pagine (da-a)254-257
Numero di pagine4
RivistaBollettino Chimico Farmaceutico
Volume140
Stato di pubblicazionePublished - 2001

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Surface-Active Agents
Tryptophan
Serotonin
Dioctyl Sulfosuccinic Acid
Water
Micelles
Spectrum Analysis

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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@article{219b395533544086a291f8a150595ebb,
title = "Interactions of tryptophan and serotonin with biomembrane models: Binding to reversed micellar systems of ionic and non ionic surfactants",
abstract = "The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.",
keywords = "Membrane models; Reversed micelles; Serotonin; Solubilization; Tryptophan; UV-spectroscopy; Molecular Medicine",
author = "Leopoldo Ceraulo and Mirella Ferrugia and {Turco Liveri}, Vincenzo and David Bongiorno and Giuseppe Avellone and Mirella Ferrugia and David Bongiorno and Leopoldo Ceraulo and Giuseppe Avellone and {Turco Liveri}, Vincenzo",
year = "2001",
language = "English",
volume = "140",
pages = "254--257",
journal = "Bollettino Chimico Farmaceutico",
issn = "0006-6648",
publisher = "Societa Editoriale Farmaceutica",

}

TY - JOUR

T1 - Interactions of tryptophan and serotonin with biomembrane models: Binding to reversed micellar systems of ionic and non ionic surfactants

AU - Ceraulo, Leopoldo

AU - Ferrugia, Mirella

AU - Turco Liveri, Vincenzo

AU - Bongiorno, David

AU - Avellone, Giuseppe

AU - Ferrugia, Mirella

AU - Bongiorno, David

AU - Ceraulo, Leopoldo

AU - Avellone, Giuseppe

AU - Turco Liveri, Vincenzo

PY - 2001

Y1 - 2001

N2 - The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.

AB - The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.

KW - Membrane models; Reversed micelles; Serotonin; Solubilization; Tryptophan; UV-spectroscopy; Molecular Medicine

UR - http://hdl.handle.net/10447/243609

M3 - Article

VL - 140

SP - 254

EP - 257

JO - Bollettino Chimico Farmaceutico

JF - Bollettino Chimico Farmaceutico

SN - 0006-6648

ER -