Interactions of tryptophan and serotonin with biomembrane models: Binding to reversed micellar systems of ionic and non ionic surfactants

Mirella Ferrugia, Leopoldo Ceraulo, Giuseppe Avellone, David Bongiorno, Vincenzo Turco Liveri, Vincenzo Turco Liveri, Mirella Ferrugia, David Bongiorno, Leopoldo Ceraulo, Giuseppe Avellone

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)

Abstract

The interactions of Tryptophan (TRP) and Serotonin (5-HT), with water-containing sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB) and tetraethylene glycol monododecyl ether (C12E4) reversed micelles have been investigated by UV absorption spectroscopy. Our results suggest that independently of the nature of the surfactant and the amount of the water encapsulated into the micellar core, TRP and 5-HT are solubilized in the micellar phase, preferring to be located in a shallow region constituted by the hydrated surfactant head groups. This is due to the amphiphilic nature of TRP and 5-HT and the biological implications are discussed.
Lingua originaleEnglish
pagine (da-a)254-257
Numero di pagine4
RivistaBollettino Chimico Farmaceutico
Volume140
Stato di pubblicazionePublished - 2001

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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