Interaction of Novel Metal Complexes with DNA: Synthetic and Structural Aspects

Maria Grazia Santangelo, Bernhard Spingler, Maria Grazia Santangelo, Chiara Da Pieve, Alfredo Medina-Molner, Philipp M. Antoni

Risultato della ricerca: Articlepeer review

7 Citazioni (Scopus)

Abstract

Metal ions bind to nucleic acids at various positions. This binding can be modulated by using metal complexes with appropriate ligands. Novel mono- and especially dinuclear metal complexes could be a powerful tool to detect rare, but still physiologically relevant, forms of DNA, e.g. the left-handed Z-DNA. In this review, our recent research activities in this area of bioinorganic chemistry are summarized. A special emphasis is laid on the synthetic challenges that arose upon the synthesis of the polyamine ligands. Further, some rather unusual approaches to elucidate the solution structure of copper bound to guanosine monophosphate with the help of pulsed EPR techniques like ENDOR and HYSCORE are described.
Lingua originaleEnglish
pagine (da-a)153-156
Numero di pagine4
RivistaChimia
Volume63
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

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