Interaction of alcohol intake and cofactors on the risk of cirrhosis.

Pier Luigi Almasio, Lorenzo A. Surace, Carmela Loguercio, Stefano Bellentani, Tommaso Stroffolini, Enzo Petrelli, Maria T. Salerno, Gaetano Cotticelli, Emanuela Medda, Antonio Picardi, Piero Almasio, Giovanni Addolorato, Camillo Del Vecchio-Blanco, Maria T. Salerno, Mauro Bernardi, Marco Niosi

Risultato della ricerca: Article

32 Citazioni (Scopus)

Abstract

OBJECTIVE: Evaluation of the interaction between alcohol intake and cofactors [hepatitis B virus (HBV), hepatitis C virus (HCV), body mass index] and coffee consumption on the risk of cirrhosis.DESIGN: Seven hundred and forty-nine consecutive patients with chronic liver disease referring to units for liver or alcohol diseases in Italy during a 6-months period. Teetotalers were excluded. The odds ratios (OR) for cirrhosis were evaluated using chronic hepatitis cases as the control group.RESULTS: An alcohol intake of more than 3 units/day resulted associated with the likelihood of cirrhosis both in males (OR 4.3; 95% CI=2.5-7.3) and in females (OR 5.7; 95% CI=2.3-14.5). A multiplicative interaction on the risk of cirrhosis between risky alcohol intake and HBsAg or HCV-Ab/HCV-RNA positivity was observed. A reduction of cirrhosis risk was observed in subjects consuming more than 3 alcohol units/day with increasing coffee intake. The OR for the association with cirrhosis decreased from 2.3 (95% CI=1.2-4.4) in subjects drinking 0-2 cups of coffee/day to 1.4 (95% CI=0.6-3.6) in those drinking more than 2 cups/day.CONCLUSIONS: In subjects with an alcohol intake >3 units/day the coexistence of HBV or HCV multiplies the risk of cirrhosis. Coffee represents a modulator of alcoholic cirrhosis risk.
Lingua originaleEnglish
Numero di pagine4
RivistaLiver International
Volume30
Stato di pubblicazionePublished - 2010

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Fibrosis
Alcohols
Coffee
Hepacivirus
Odds Ratio
Hepatitis B virus
Drinking
Alcoholic Liver Cirrhosis
Chronic Hepatitis
Risk Reduction Behavior
Hepatitis B Surface Antigens
Italy
Liver Diseases
Body Mass Index
Chronic Disease
RNA
Control Groups
Liver

All Science Journal Classification (ASJC) codes

  • Hepatology

Cita questo

Almasio, P. L., Surace, L. A., Loguercio, C., Bellentani, S., Stroffolini, T., Petrelli, E., ... Niosi, M. (2010). Interaction of alcohol intake and cofactors on the risk of cirrhosis. Liver International, 30.

Interaction of alcohol intake and cofactors on the risk of cirrhosis. / Almasio, Pier Luigi; Surace, Lorenzo A.; Loguercio, Carmela; Bellentani, Stefano; Stroffolini, Tommaso; Petrelli, Enzo; Salerno, Maria T.; Cotticelli, Gaetano; Medda, Emanuela; Picardi, Antonio; Almasio, Piero; Addolorato, Giovanni; Del Vecchio-Blanco, Camillo; Salerno, Maria T.; Bernardi, Mauro; Niosi, Marco.

In: Liver International, Vol. 30, 2010.

Risultato della ricerca: Article

Almasio, PL, Surace, LA, Loguercio, C, Bellentani, S, Stroffolini, T, Petrelli, E, Salerno, MT, Cotticelli, G, Medda, E, Picardi, A, Almasio, P, Addolorato, G, Del Vecchio-Blanco, C, Salerno, MT, Bernardi, M & Niosi, M 2010, 'Interaction of alcohol intake and cofactors on the risk of cirrhosis.', Liver International, vol. 30.
Almasio PL, Surace LA, Loguercio C, Bellentani S, Stroffolini T, Petrelli E e altri. Interaction of alcohol intake and cofactors on the risk of cirrhosis. Liver International. 2010;30.
Almasio, Pier Luigi ; Surace, Lorenzo A. ; Loguercio, Carmela ; Bellentani, Stefano ; Stroffolini, Tommaso ; Petrelli, Enzo ; Salerno, Maria T. ; Cotticelli, Gaetano ; Medda, Emanuela ; Picardi, Antonio ; Almasio, Piero ; Addolorato, Giovanni ; Del Vecchio-Blanco, Camillo ; Salerno, Maria T. ; Bernardi, Mauro ; Niosi, Marco. / Interaction of alcohol intake and cofactors on the risk of cirrhosis. In: Liver International. 2010 ; Vol. 30.
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title = "Interaction of alcohol intake and cofactors on the risk of cirrhosis.",
abstract = "OBJECTIVE: Evaluation of the interaction between alcohol intake and cofactors [hepatitis B virus (HBV), hepatitis C virus (HCV), body mass index] and coffee consumption on the risk of cirrhosis.DESIGN: Seven hundred and forty-nine consecutive patients with chronic liver disease referring to units for liver or alcohol diseases in Italy during a 6-months period. Teetotalers were excluded. The odds ratios (OR) for cirrhosis were evaluated using chronic hepatitis cases as the control group.RESULTS: An alcohol intake of more than 3 units/day resulted associated with the likelihood of cirrhosis both in males (OR 4.3; 95{\%} CI=2.5-7.3) and in females (OR 5.7; 95{\%} CI=2.3-14.5). A multiplicative interaction on the risk of cirrhosis between risky alcohol intake and HBsAg or HCV-Ab/HCV-RNA positivity was observed. A reduction of cirrhosis risk was observed in subjects consuming more than 3 alcohol units/day with increasing coffee intake. The OR for the association with cirrhosis decreased from 2.3 (95{\%} CI=1.2-4.4) in subjects drinking 0-2 cups of coffee/day to 1.4 (95{\%} CI=0.6-3.6) in those drinking more than 2 cups/day.CONCLUSIONS: In subjects with an alcohol intake >3 units/day the coexistence of HBV or HCV multiplies the risk of cirrhosis. Coffee represents a modulator of alcoholic cirrhosis risk.",
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author = "Almasio, {Pier Luigi} and Surace, {Lorenzo A.} and Carmela Loguercio and Stefano Bellentani and Tommaso Stroffolini and Enzo Petrelli and Salerno, {Maria T.} and Gaetano Cotticelli and Emanuela Medda and Antonio Picardi and Piero Almasio and Giovanni Addolorato and {Del Vecchio-Blanco}, Camillo and Salerno, {Maria T.} and Mauro Bernardi and Marco Niosi",
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T1 - Interaction of alcohol intake and cofactors on the risk of cirrhosis.

AU - Almasio, Pier Luigi

AU - Surace, Lorenzo A.

AU - Loguercio, Carmela

AU - Bellentani, Stefano

AU - Stroffolini, Tommaso

AU - Petrelli, Enzo

AU - Salerno, Maria T.

AU - Cotticelli, Gaetano

AU - Medda, Emanuela

AU - Picardi, Antonio

AU - Almasio, Piero

AU - Addolorato, Giovanni

AU - Del Vecchio-Blanco, Camillo

AU - Salerno, Maria T.

AU - Bernardi, Mauro

AU - Niosi, Marco

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: Evaluation of the interaction between alcohol intake and cofactors [hepatitis B virus (HBV), hepatitis C virus (HCV), body mass index] and coffee consumption on the risk of cirrhosis.DESIGN: Seven hundred and forty-nine consecutive patients with chronic liver disease referring to units for liver or alcohol diseases in Italy during a 6-months period. Teetotalers were excluded. The odds ratios (OR) for cirrhosis were evaluated using chronic hepatitis cases as the control group.RESULTS: An alcohol intake of more than 3 units/day resulted associated with the likelihood of cirrhosis both in males (OR 4.3; 95% CI=2.5-7.3) and in females (OR 5.7; 95% CI=2.3-14.5). A multiplicative interaction on the risk of cirrhosis between risky alcohol intake and HBsAg or HCV-Ab/HCV-RNA positivity was observed. A reduction of cirrhosis risk was observed in subjects consuming more than 3 alcohol units/day with increasing coffee intake. The OR for the association with cirrhosis decreased from 2.3 (95% CI=1.2-4.4) in subjects drinking 0-2 cups of coffee/day to 1.4 (95% CI=0.6-3.6) in those drinking more than 2 cups/day.CONCLUSIONS: In subjects with an alcohol intake >3 units/day the coexistence of HBV or HCV multiplies the risk of cirrhosis. Coffee represents a modulator of alcoholic cirrhosis risk.

AB - OBJECTIVE: Evaluation of the interaction between alcohol intake and cofactors [hepatitis B virus (HBV), hepatitis C virus (HCV), body mass index] and coffee consumption on the risk of cirrhosis.DESIGN: Seven hundred and forty-nine consecutive patients with chronic liver disease referring to units for liver or alcohol diseases in Italy during a 6-months period. Teetotalers were excluded. The odds ratios (OR) for cirrhosis were evaluated using chronic hepatitis cases as the control group.RESULTS: An alcohol intake of more than 3 units/day resulted associated with the likelihood of cirrhosis both in males (OR 4.3; 95% CI=2.5-7.3) and in females (OR 5.7; 95% CI=2.3-14.5). A multiplicative interaction on the risk of cirrhosis between risky alcohol intake and HBsAg or HCV-Ab/HCV-RNA positivity was observed. A reduction of cirrhosis risk was observed in subjects consuming more than 3 alcohol units/day with increasing coffee intake. The OR for the association with cirrhosis decreased from 2.3 (95% CI=1.2-4.4) in subjects drinking 0-2 cups of coffee/day to 1.4 (95% CI=0.6-3.6) in those drinking more than 2 cups/day.CONCLUSIONS: In subjects with an alcohol intake >3 units/day the coexistence of HBV or HCV multiplies the risk of cirrhosis. Coffee represents a modulator of alcoholic cirrhosis risk.

KW - alcohol

UR - http://hdl.handle.net/10447/81205

M3 - Article

VL - 30

JO - Liver International

JF - Liver International

SN - 1478-3223

ER -