Interaction between cannabis consumption and childhood abuse in psychotic disorders: preliminary findings on the role of different patterns of cannabis use

Daniele La Barbera, Lucia Sideli, Caterina La Cascia, Laura Ferraro, Jennifer A. O'Connor, Helen L. Fisher, Marta Di Forti, Benjamin D.R. Wiffen, Lucia Sideli, Robin M. Murray, Simona A. Stilo, Alessandra Paparelli, Manuela Russo, Hannah Sallis, Sonia Pintore, Craig Morgan

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

AIM: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. METHODS: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questionnaire. Childhood physical and sexual abuse was assessed using the Childhood Experience of Care and Abuse Questionnaire. RESULTS: Neither lifetime cannabis use nor reported exposure to childhood abuse was associated with psychotic disorder when the other environmental variable was taken into account. Although the combination of the two risk factors raised the odds for psychosis by nearly three times (adjusted OR = 2.94, 95% CI: 1.44-6.02, P = 0.003), no evidence of interaction was found (adjusted OR = 1.46, 95% CI: -0.54 to 3.46, P = 0.152). Furthermore, the association of high-potency cannabis and daily consumption with psychosis was at least partially independent of the effect of childhood abuse. CONCLUSIONS: The heavy use of high-potency cannabis increases the risk of psychosis but, in addition, smoking of traditional resin (hash) and less than daily cannabis use may increase the risk for psychosis when combined with exposure to severe childhood abuse.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine8
RivistaEarly Intervention in Psychiatry
Stato di pubblicazionePublished - 2015

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Cannabis
Psychotic Disorders
Marijuana Abuse
Population Control
Sex Offenses
Mental Health Services
Smoking

All Science Journal Classification (ASJC) codes

  • Phychiatric Mental Health
  • Biological Psychiatry
  • Psychiatry and Mental health

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Interaction between cannabis consumption and childhood abuse in psychotic disorders: preliminary findings on the role of different patterns of cannabis use. / La Barbera, Daniele; Sideli, Lucia; La Cascia, Caterina; Ferraro, Laura; O'Connor, Jennifer A.; Fisher, Helen L.; Di Forti, Marta; Wiffen, Benjamin D.R.; Sideli, Lucia; Murray, Robin M.; Stilo, Simona A.; Paparelli, Alessandra; Russo, Manuela; Sallis, Hannah; Pintore, Sonia; Morgan, Craig.

In: Early Intervention in Psychiatry, 2015, pag. -.

Risultato della ricerca: Article

La Barbera, D, Sideli, L, La Cascia, C, Ferraro, L, O'Connor, JA, Fisher, HL, Di Forti, M, Wiffen, BDR, Sideli, L, Murray, RM, Stilo, SA, Paparelli, A, Russo, M, Sallis, H, Pintore, S & Morgan, C 2015, 'Interaction between cannabis consumption and childhood abuse in psychotic disorders: preliminary findings on the role of different patterns of cannabis use', Early Intervention in Psychiatry, pagg. -.
La Barbera, Daniele ; Sideli, Lucia ; La Cascia, Caterina ; Ferraro, Laura ; O'Connor, Jennifer A. ; Fisher, Helen L. ; Di Forti, Marta ; Wiffen, Benjamin D.R. ; Sideli, Lucia ; Murray, Robin M. ; Stilo, Simona A. ; Paparelli, Alessandra ; Russo, Manuela ; Sallis, Hannah ; Pintore, Sonia ; Morgan, Craig. / Interaction between cannabis consumption and childhood abuse in psychotic disorders: preliminary findings on the role of different patterns of cannabis use. In: Early Intervention in Psychiatry. 2015 ; pagg. -.
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title = "Interaction between cannabis consumption and childhood abuse in psychotic disorders: preliminary findings on the role of different patterns of cannabis use",
abstract = "AIM: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. METHODS: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questionnaire. Childhood physical and sexual abuse was assessed using the Childhood Experience of Care and Abuse Questionnaire. RESULTS: Neither lifetime cannabis use nor reported exposure to childhood abuse was associated with psychotic disorder when the other environmental variable was taken into account. Although the combination of the two risk factors raised the odds for psychosis by nearly three times (adjusted OR = 2.94, 95{\%} CI: 1.44-6.02, P = 0.003), no evidence of interaction was found (adjusted OR = 1.46, 95{\%} CI: -0.54 to 3.46, P = 0.152). Furthermore, the association of high-potency cannabis and daily consumption with psychosis was at least partially independent of the effect of childhood abuse. CONCLUSIONS: The heavy use of high-potency cannabis increases the risk of psychosis but, in addition, smoking of traditional resin (hash) and less than daily cannabis use may increase the risk for psychosis when combined with exposure to severe childhood abuse.",
author = "{La Barbera}, Daniele and Lucia Sideli and {La Cascia}, Caterina and Laura Ferraro and O'Connor, {Jennifer A.} and Fisher, {Helen L.} and {Di Forti}, Marta and Wiffen, {Benjamin D.R.} and Lucia Sideli and Murray, {Robin M.} and Stilo, {Simona A.} and Alessandra Paparelli and Manuela Russo and Hannah Sallis and Sonia Pintore and Craig Morgan",
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T1 - Interaction between cannabis consumption and childhood abuse in psychotic disorders: preliminary findings on the role of different patterns of cannabis use

AU - La Barbera, Daniele

AU - Sideli, Lucia

AU - La Cascia, Caterina

AU - Ferraro, Laura

AU - O'Connor, Jennifer A.

AU - Fisher, Helen L.

AU - Di Forti, Marta

AU - Wiffen, Benjamin D.R.

AU - Sideli, Lucia

AU - Murray, Robin M.

AU - Stilo, Simona A.

AU - Paparelli, Alessandra

AU - Russo, Manuela

AU - Sallis, Hannah

AU - Pintore, Sonia

AU - Morgan, Craig

PY - 2015

Y1 - 2015

N2 - AIM: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. METHODS: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questionnaire. Childhood physical and sexual abuse was assessed using the Childhood Experience of Care and Abuse Questionnaire. RESULTS: Neither lifetime cannabis use nor reported exposure to childhood abuse was associated with psychotic disorder when the other environmental variable was taken into account. Although the combination of the two risk factors raised the odds for psychosis by nearly three times (adjusted OR = 2.94, 95% CI: 1.44-6.02, P = 0.003), no evidence of interaction was found (adjusted OR = 1.46, 95% CI: -0.54 to 3.46, P = 0.152). Furthermore, the association of high-potency cannabis and daily consumption with psychosis was at least partially independent of the effect of childhood abuse. CONCLUSIONS: The heavy use of high-potency cannabis increases the risk of psychosis but, in addition, smoking of traditional resin (hash) and less than daily cannabis use may increase the risk for psychosis when combined with exposure to severe childhood abuse.

AB - AIM: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. METHODS: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questionnaire. Childhood physical and sexual abuse was assessed using the Childhood Experience of Care and Abuse Questionnaire. RESULTS: Neither lifetime cannabis use nor reported exposure to childhood abuse was associated with psychotic disorder when the other environmental variable was taken into account. Although the combination of the two risk factors raised the odds for psychosis by nearly three times (adjusted OR = 2.94, 95% CI: 1.44-6.02, P = 0.003), no evidence of interaction was found (adjusted OR = 1.46, 95% CI: -0.54 to 3.46, P = 0.152). Furthermore, the association of high-potency cannabis and daily consumption with psychosis was at least partially independent of the effect of childhood abuse. CONCLUSIONS: The heavy use of high-potency cannabis increases the risk of psychosis but, in addition, smoking of traditional resin (hash) and less than daily cannabis use may increase the risk for psychosis when combined with exposure to severe childhood abuse.

UR - http://hdl.handle.net/10447/172000

UR - http://onlinelibrary.wiley.com/doi/10.1111/eip.12285/pdf

M3 - Article

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JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

SN - 1751-7885

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