Insight into genetic susceptibility to male breast cancer by multigene panel testing: Results from a multicenter study in Italy

Antonio Russo, Piera Rizzolo, Siranoush Manoukian, Valentina Silvestri, Jacopo Azzollini, Paolo Peterlongo, Daniele Calistri, Virginia Valentini, Domenico Palli, Laura Ottini, Alessandro Mauro Spinelli, Ines Zanna, Paolo Radice, Bernardo Bonanni, Maria Grazia Tibiletti, Marco Montagna, Veronica Zelli, Piera Rizzolo, Carlo Capalbo, Laura CortesiPaolo Peterlongo, Giovanna Masala, Liliana Varesco, Alessandra Viel, Giuseppe Giannini, Simonetta Bianchi, Ines Zanna, Valentina Silvestri

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16 Citazioni (Scopus)

Abstract

Breast cancer (BC) in men is rare and genetic predisposition is likely to play a relevant role in its etiology. Inherited mutations in BRCA1/2 account for about 13% of all cases and additional genes that may contribute to the missing heritability need to be investigated. In our study, a well-characterized series of 523 male BC (MBC) patients from the Italian multicenter study on MBC, enriched for non-BRCA1/2 MBC cases, was screened by a multigene custom panel of 50 cancer-associated genes. The main clinical-pathologic characteristics of MBC in pathogenic variant carriers and non-carriers were also compared. BRCA1/2 pathogenic variants were detected in twenty patients, thus, a total of 503 non-BRCA1/2 MBC patients were examined in our study. Twenty-seven of the non-BRCA1/2 MBC patients were carriers of germline pathogenic variants in other genes, including two APC p.Ile1307Lys variant carriers and one MUTYH biallelic variant carrier. PALB2 was the most frequently altered gene (1.2%) and PALB2 pathogenic variants were significantly associated with high risk of MBC. Non-BRCA1/2 pathogenic variant carriers were more likely to have personal (p = 0.0005) and family (p = 0.007) history of cancer. Results of our study support a central role of PALB2 in MBC susceptibility and show a low impact of CHEK2 on MBC predisposition in the Italian population. Overall, our data indicate that a multigene testing approach may benefit from appropriately selected patients with implications for clinical management and counseling of MBC patients and their family members.
Lingua originaleEnglish
Numero di pagine0
RivistaInternational Journal of Cancer
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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