Myo-Inositol (MI) is involved in several aspects ofhuman reproduction. Elevated concentrations ofmyo-inositol in human follicular fluids, in fact, seemto play a positive role in follicular maturity, since torepresent a possible marker of good oocyte quality.Nevertheless its positive role in PCOS patients is aconsequence of a defect in the insulin signaling (inositol-containing phosphoglycan mediators) pathwaythat seems to be implicated in the pathogenesis of insulinresistance.The aim of this study was to analyze the effect ofmyo-inositol supplementation to “standard” therapyin PCOS women and in “poor responders”, submittedto In Vitro Fecundation (IVF) cycles.In particular, we have investigated its influence onovarian response to hormonal stimulation and onoocytes quality. Preliminary results of our study, anyway,appear in contrast with results of previous studies;supplementation with MI, in fact, do not seem toimprove the response neither in PCOS patients nor inpoor responders.
|Numero di pagine||7|
|Rivista||ITALIAN JOURNAL OF GYNAECOLOGY & OBSTETRICS|
|Stato di pubblicazione||Published - 2012|
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