Initial surgery for localized rhabdomyosarcoma: a report from the italian Soft Tissue Sarcoma Cooperative Group Studies.

Fortunato Siracusa, Zanetti, Gigante, Patrizia Dall'Igna, Boglino, Gianni Bisogno, Leggio, Giovanni Cecchetto, Carli, Andrea Ferrari, De Corti

    Risultato della ricerca: Article

    Abstract

    Objective. Analysis of the initial surgical approach in patients with localized rhabdomyosarcoma, enrolled in Italian Studies (1979-2003). Methods. Surgical records of 587 patients were evaluated. As primary surgery, the excision was recommended if microscopically complete, otherwise biopsy was preferable. Results. The initial biopsy, performed in almost 50% of patients in RMS-79 protocol, has been adopted more often in the protocol RMS-88 and 96. However, the “complete resection” rate has remained quite stable through the years, as well as the percentage of microscopic residue. The macroscopic residue disease has been more important in RMS-88 study than in RMS-96. Most GUnBP tumors and about 10% of HNnPM and other site were successfully excised. A complete resection was rarely attempted in orbit, HNPM, and GUBP sites; regarding the extremities tumors, 62.5% of patients in RMS-79 study underwent a complete conservative excision, while most patients in RMS-88 and 96 underwent biopsy only. Conclusion. Initial surgical approach has become more conservative, avoiding mutilations, but the incomplete resection rate is still high. A satisfactory initial excision was obtained. in GUnBP RMS (mainly paratesticular). In other localizations the feasibility of a complete resection was slightly better for T1a RMS; a careful preoperative evaluation is always necessary.
    Lingua originaleEnglish
    pagine (da-a)383-388
    Numero di pagine6
    RivistaTHE ITALIAN JOURNAL OF PEDIATRICS
    Volume51
    Stato di pubblicazionePublished - 2005

    Fingerprint

    Rhabdomyosarcoma
    Sarcoma
    Biopsy
    Orbit
    Neoplasms
    Extremities

    All Science Journal Classification (ASJC) codes

    • Pediatrics, Perinatology, and Child Health

    Cita questo

    Initial surgery for localized rhabdomyosarcoma: a report from the italian Soft Tissue Sarcoma Cooperative Group Studies. / Siracusa, Fortunato; Zanetti; Gigante; Dall'Igna, Patrizia; Boglino; Bisogno, Gianni; Leggio; Cecchetto, Giovanni; Carli; Ferrari, Andrea; De Corti.

    In: THE ITALIAN JOURNAL OF PEDIATRICS, Vol. 51, 2005, pag. 383-388.

    Risultato della ricerca: Article

    Siracusa, F, Zanetti, Gigante, Dall'Igna, P, Boglino, Bisogno, G, Leggio, Cecchetto, G, Carli, Ferrari, A & De Corti 2005, 'Initial surgery for localized rhabdomyosarcoma: a report from the italian Soft Tissue Sarcoma Cooperative Group Studies.', THE ITALIAN JOURNAL OF PEDIATRICS, vol. 51, pagg. 383-388.
    Siracusa, Fortunato ; Zanetti ; Gigante ; Dall'Igna, Patrizia ; Boglino ; Bisogno, Gianni ; Leggio ; Cecchetto, Giovanni ; Carli ; Ferrari, Andrea ; De Corti. / Initial surgery for localized rhabdomyosarcoma: a report from the italian Soft Tissue Sarcoma Cooperative Group Studies. In: THE ITALIAN JOURNAL OF PEDIATRICS. 2005 ; Vol. 51. pagg. 383-388.
    @article{8ae9c07b42964a8e882354a49f34bb41,
    title = "Initial surgery for localized rhabdomyosarcoma: a report from the italian Soft Tissue Sarcoma Cooperative Group Studies.",
    abstract = "Objective. Analysis of the initial surgical approach in patients with localized rhabdomyosarcoma, enrolled in Italian Studies (1979-2003). Methods. Surgical records of 587 patients were evaluated. As primary surgery, the excision was recommended if microscopically complete, otherwise biopsy was preferable. Results. The initial biopsy, performed in almost 50{\%} of patients in RMS-79 protocol, has been adopted more often in the protocol RMS-88 and 96. However, the “complete resection” rate has remained quite stable through the years, as well as the percentage of microscopic residue. The macroscopic residue disease has been more important in RMS-88 study than in RMS-96. Most GUnBP tumors and about 10{\%} of HNnPM and other site were successfully excised. A complete resection was rarely attempted in orbit, HNPM, and GUBP sites; regarding the extremities tumors, 62.5{\%} of patients in RMS-79 study underwent a complete conservative excision, while most patients in RMS-88 and 96 underwent biopsy only. Conclusion. Initial surgical approach has become more conservative, avoiding mutilations, but the incomplete resection rate is still high. A satisfactory initial excision was obtained. in GUnBP RMS (mainly paratesticular). In other localizations the feasibility of a complete resection was slightly better for T1a RMS; a careful preoperative evaluation is always necessary.",
    author = "Fortunato Siracusa and Zanetti and Gigante and Patrizia Dall'Igna and Boglino and Gianni Bisogno and Leggio and Giovanni Cecchetto and Carli and Andrea Ferrari and {De Corti}",
    year = "2005",
    language = "English",
    volume = "51",
    pages = "383--388",
    journal = "Italian Journal of Pediatrics",
    issn = "1720-8424",
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    TY - JOUR

    T1 - Initial surgery for localized rhabdomyosarcoma: a report from the italian Soft Tissue Sarcoma Cooperative Group Studies.

    AU - Siracusa, Fortunato

    AU - Zanetti, null

    AU - Gigante, null

    AU - Dall'Igna, Patrizia

    AU - Boglino, null

    AU - Bisogno, Gianni

    AU - Leggio, null

    AU - Cecchetto, Giovanni

    AU - Carli, null

    AU - Ferrari, Andrea

    AU - De Corti, null

    PY - 2005

    Y1 - 2005

    N2 - Objective. Analysis of the initial surgical approach in patients with localized rhabdomyosarcoma, enrolled in Italian Studies (1979-2003). Methods. Surgical records of 587 patients were evaluated. As primary surgery, the excision was recommended if microscopically complete, otherwise biopsy was preferable. Results. The initial biopsy, performed in almost 50% of patients in RMS-79 protocol, has been adopted more often in the protocol RMS-88 and 96. However, the “complete resection” rate has remained quite stable through the years, as well as the percentage of microscopic residue. The macroscopic residue disease has been more important in RMS-88 study than in RMS-96. Most GUnBP tumors and about 10% of HNnPM and other site were successfully excised. A complete resection was rarely attempted in orbit, HNPM, and GUBP sites; regarding the extremities tumors, 62.5% of patients in RMS-79 study underwent a complete conservative excision, while most patients in RMS-88 and 96 underwent biopsy only. Conclusion. Initial surgical approach has become more conservative, avoiding mutilations, but the incomplete resection rate is still high. A satisfactory initial excision was obtained. in GUnBP RMS (mainly paratesticular). In other localizations the feasibility of a complete resection was slightly better for T1a RMS; a careful preoperative evaluation is always necessary.

    AB - Objective. Analysis of the initial surgical approach in patients with localized rhabdomyosarcoma, enrolled in Italian Studies (1979-2003). Methods. Surgical records of 587 patients were evaluated. As primary surgery, the excision was recommended if microscopically complete, otherwise biopsy was preferable. Results. The initial biopsy, performed in almost 50% of patients in RMS-79 protocol, has been adopted more often in the protocol RMS-88 and 96. However, the “complete resection” rate has remained quite stable through the years, as well as the percentage of microscopic residue. The macroscopic residue disease has been more important in RMS-88 study than in RMS-96. Most GUnBP tumors and about 10% of HNnPM and other site were successfully excised. A complete resection was rarely attempted in orbit, HNPM, and GUBP sites; regarding the extremities tumors, 62.5% of patients in RMS-79 study underwent a complete conservative excision, while most patients in RMS-88 and 96 underwent biopsy only. Conclusion. Initial surgical approach has become more conservative, avoiding mutilations, but the incomplete resection rate is still high. A satisfactory initial excision was obtained. in GUnBP RMS (mainly paratesticular). In other localizations the feasibility of a complete resection was slightly better for T1a RMS; a careful preoperative evaluation is always necessary.

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    SP - 383

    EP - 388

    JO - Italian Journal of Pediatrics

    JF - Italian Journal of Pediatrics

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