Abstract
STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growthfactors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronicmyelogenous leukemia, acute lymphoblastic leukemia and Hodgkin’s lymphoma. Recently, literaturereported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis inCML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives withcytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.
Lingua originale | English |
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pagine (da-a) | 4568-4574 |
Numero di pagine | 7 |
Rivista | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
Volume | 24 |
Stato di pubblicazione | Published - 2014 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry