Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cellswith new pimozide derivatives

Maria Meli; Rosaria Maria Pipitone; Stefania Grimaudo; Cristiana Costantini; Giacomo Padroni; Sara Fochi; Paolo Marchetti; Riccardo Baruchello; Riccardo Rondanin; Daniele Simoni; Romeo Romagnoli

Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cellswith new pimozide derivatives

Maria Meli, Rosaria Maria Pipitone, Stefania Grimaudo, Cristiana Costantini, Giacomo Padroni, Sara Fochi, Paolo Marchetti, Riccardo Baruchello, Riccardo Rondanin, Daniele Simoni, Romeo Romagnoli

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

18 Citazioni (Scopus)

Abstract

STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growthfactors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronicmyelogenous leukemia, acute lymphoblastic leukemia and Hodgkin’s lymphoma. Recently, literaturereported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis inCML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives withcytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.

Lingua originale	English
pagine (da-a)	4568-4574
Numero di pagine	7
Rivista	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume	24
Stato di pubblicazione	Published - 2014

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Fingerprint Entra nei temi di ricerca di 'Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cellswith new pimozide derivatives'. Insieme formano una fingerprint unica.

Cita questo

Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cellswith new pimozide derivatives. / Meli, Maria ; Pipitone, Rosaria Maria ; Grimaudo, Stefania; Costantini, Cristiana; Padroni, Giacomo; Fochi, Sara; Marchetti, Paolo; Baruchello, Riccardo; Rondanin, Riccardo; Simoni, Daniele; Romagnoli, Romeo.

In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 24, 2014, pag. 4568-4574.

Risultato della ricerca: Article › peer review

Meli, Maria ; Pipitone, Rosaria Maria ; Grimaudo, Stefania ; Costantini, Cristiana ; Padroni, Giacomo ; Fochi, Sara ; Marchetti, Paolo ; Baruchello, Riccardo ; Rondanin, Riccardo ; Simoni, Daniele ; Romagnoli, Romeo. / Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cellswith new pimozide derivatives. In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2014 ; Vol. 24. pagg. 4568-4574.

@article{c5922dc118144ffaad731893bf9dd684,

title = "Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cellswith new pimozide derivatives",

abstract = "STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growthfactors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronicmyelogenous leukemia, acute lymphoblastic leukemia and Hodgkin{\textquoteright}s lymphoma. Recently, literaturereported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis inCML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives withcytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.",

author = "Maria Meli and Pipitone, {Rosaria Maria} and Stefania Grimaudo and Cristiana Costantini and Giacomo Padroni and Sara Fochi and Paolo Marchetti and Riccardo Baruchello and Riccardo Rondanin and Daniele Simoni and Romeo Romagnoli",

year = "2014",

language = "English",

volume = "24",

pages = "4568--4574",

journal = "BIOORGANIC & MEDICINAL CHEMISTRY LETTERS",

issn = "0960-894X",

}

TY - JOUR

T1 - Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cellswith new pimozide derivatives

AU - Meli, Maria

AU - Pipitone, Rosaria Maria

AU - Grimaudo, Stefania

AU - Costantini, Cristiana

AU - Padroni, Giacomo

AU - Fochi, Sara

AU - Marchetti, Paolo

AU - Baruchello, Riccardo

AU - Rondanin, Riccardo

AU - Simoni, Daniele

AU - Romagnoli, Romeo

PY - 2014

Y1 - 2014

N2 - STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growthfactors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronicmyelogenous leukemia, acute lymphoblastic leukemia and Hodgkin’s lymphoma. Recently, literaturereported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis inCML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives withcytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.

AB - STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growthfactors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronicmyelogenous leukemia, acute lymphoblastic leukemia and Hodgkin’s lymphoma. Recently, literaturereported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis inCML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives withcytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.

UR - http://hdl.handle.net/10447/96244

M3 - Article

VL - 24

SP - 4568

EP - 4574

JO - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SN - 0960-894X

ER -