Inhaler mishandling remains common in real life and is associated with reduced disease control

Nicola Scichilone, Margherita Neri, Vincenzo Cilenti, Marco Lodi, Andrea S. Melani, Piersante Sestini, Maria Serra, Maria Serra, Paola Martucci, Marco Bonavia, Maria Aliani, Cristina Cinti, Maria Serra

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612 Citazioni (Scopus)


Inhalers and nebulisers are devices used for delivering aerosolised drugs insubjects with Chronic Airflow Obstruction (CAO). This multicentre,cross-sectional observational study was performed in a large population ofoutpatients with CAO regularly using home aerosol therapy and referring to chest clinics. The aims of the study were to compare the characteristics of the groupof subjects with CAO who were using home nebulisers but also experienced withinhalers vs. those only using inhalers and to investigate whether the first groupof subjects was particularly prone to inhaler misuse. Information was gainedevaluating the responses to a standardised questionnaire on home aerosol therapy and the observations of inhaler technique. We enrolled 1527 patients (58% males; mean ± SE; aged 61.1 ± 0.4 years; FEV1% pred 69.9 ± 0.6; 51% and 44% respectivelysuffering from COPD and asthma) who were only inhaler users (OIU group) and 137(85% males; aged 67.7 ± 1.3 years; FEV1% pred 62.3 ± 2.9; 60% and 23%respectively suffering from COPD and asthma) who were using both nebulisers andinhalers (NIU group). Nebuliser users were older, had more severe obstruction,related symptoms and health care resources utilisation. Nebulisers usersperformed more critical inhalers errors than those of the OIU group (49% vs. 36%;p = 0.009). We conclude that our patients with CAO and regular nebulisertreatment had advanced age, severe respiratory conditions and common inhalermisuse.
Lingua originaleEnglish
pagine (da-a)930-938
Numero di pagine9
RivistaRespiratory Medicine
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

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