Influence of myocardial fibrosis and blood oxygenation on heart T2* values in thalassemia patients.

Massimo Midiri, Calogera Gerardi, Alessia Pepe, Luigi Landini, Carmela Lo Pinto, Antonella Meloni, Vincenzo Positano, Marcello Capra, Maria Filomena Santarelli, Aurelio Maggio, Massimo Lombardi, Brunella Favilli

Risultato della ricerca: Articlepeer review

24 Citazioni (Scopus)

Abstract

PURPOSE: To determine whether T2* measurements quantifying myocardial iron overload in thalassemia patients are influenced by myocardial fibrosis and blood oxygenation. MATERIALS AND METHODS: Multislice multiecho T2* was performed in 94 thalassemia patients in order to quantify myocardial iron overload. The left ventricle was automatically segmented into a 16-segment standardized heart model, and the T2* value on each segment as well as the global T2* were calculated. Delayed enhanced cardiovascular magnetic resonance (DE-CMR) images were obtained to detect myocardial fibrosis. The blood oxygenation was assessed by the noninvasive measurement of partial pressure of oxygen (pO2). RESULTS: Myocardial fibrosis was detected in 31 patients (33%). The global T2* value in patients with fibrosis was comparable with that of patients without fibrosis (P = 0.88) and T2* values in segments with fibrosis were comparable with those in segments without fibrosis (P = 0.83). The global T2* value was not correlated with the pO2 (Spearman's coefficient of correlation = 0.99). CONCLUSION: Myocardial fibrosis and blood oxygenation did not significantly affect the T2* values. These data further support the use of heart T2* as equivalent of heart iron in the clinical arena.
Lingua originaleEnglish
pagine (da-a)832-837
Numero di pagine6
RivistaJournal of Magnetic Resonance Imaging
Volume29
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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