Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans

Clelia Dispenza, Maria Antonietta Sabatino, Simona Todaro, Marta Walo, Dispenza, Todaro, Maria Rosalia Mangione, Bulone

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

Thermoresponsive degalactosylated xyloglucans have been already proposed as in situ gelling scaffolds for tissue engineering, due to the irreversible macroscopic thermal gelation at body temperature and biodegradability. The highly branched, hydroxyl group-rich molecular structure renders xyloglucansinteresting raw materials also in the form of micro/nanoparticles for application as nanoscalar drugdelivery devices in cosmetic and pharmaceutical formulations.Owing to their natural source,xyloglucans show high average molecular weight, broad molecular weight distribution and poor water solubility, as large and compact aggregates usually form via inter-molecular hydrogen bonding. 60Co γ-irradiation has been here applied to reduce the molecular weight. The aqueous solutions of irradiatedxyloglucan were characterized by dynamic light scattering measurements and gel filtration chromatography. Theaggregation kinetics at 37°C were studied by dynamic light scattering measurements toconfirm the temperature-responsive behavior of this polymer even when dispersed in water at lowconcentration after γ-irradiation. Irradiation dose–molecular properties relationship has been sought.
Lingua originaleEnglish
pagine (da-a)245-248
Numero di pagine4
RivistaRadiation Physics and Chemistry
Volume94
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Radiation

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