4 Citazioni (Scopus)

Abstract

The Ciona intestinalis inflammatory response to several irritants appears to be composed of a complex reaction set. The cellular reactions in the tunic involve hemocyte infiltration, hemocyte and epidermis activities, vacuolization, and cell disruption, while cell products can contribute to form capsule components and/or cause a tunic wound. In this response, the involvement of the pharynx, as the main immune-competent organ, has been disclosed by a lipopolysaccharide challenge that upregulates innate immunity genes and transcription activation genes. The pharynx responds through hemocyte recruitment into the pharynx vessels, enhancement of galectin-like lectins in the serum hemolymph, an alternative complement pathway, and phenoloxidase system activity. Upregulation involves genes for C-type lectins (CiCD94, CiMBL), galectins, cytokines (CiTNF?, IL17-like), phenoloxidase, FACIT-type IX-like collagen, and a transcription activator gene (CiCAP). The encoded proteins are components of distinct molecular families that support the evolution of several mechanisms, which generate sequence diversity in genes with immune functions. Clusters of similar genes or exons strengthen the concept that inflammatory factors are part of large molecular families originated by a process of divergent evolution from a common ancestor and in some cases of gene co-option during evolution.
Lingua originaleEnglish
Titolo della pubblicazione ospiteLessons in Immunity: From Single-cell Organisms to Mammals
Pagine177-192
Numero di pagine16
Stato di pubblicazionePublished - 2016

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Ciona intestinalis
Urochordata
Hemocytes
Pharynx
Galectins
Monophenol Monooxygenase
Genes
Transcriptional Activation
Up-Regulation
Collagen Type IX
C-Type Lectins
Alternative Complement Pathway
Hemolymph
Irritants
Multigene Family
Lectins
Innate Immunity
Epidermis
Capsules
Lipopolysaccharides

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

Cita questo

Parrinello, D., Cammarata, M., Vizzini, A., & Parrinello, N. (2016). Inflammatory Response of the Ascidian Ciona intestinalis. In Lessons in Immunity: From Single-cell Organisms to Mammals (pagg. 177-192)

Inflammatory Response of the Ascidian Ciona intestinalis. / Parrinello, Daniela; Cammarata, Matteo; Vizzini, Aiti; Parrinello, Nicolo'.

Lessons in Immunity: From Single-cell Organisms to Mammals. 2016. pag. 177-192.

Risultato della ricerca: Chapter

Parrinello, D, Cammarata, M, Vizzini, A & Parrinello, N 2016, Inflammatory Response of the Ascidian Ciona intestinalis. in Lessons in Immunity: From Single-cell Organisms to Mammals. pagg. 177-192.
Parrinello D, Cammarata M, Vizzini A, Parrinello N. Inflammatory Response of the Ascidian Ciona intestinalis. In Lessons in Immunity: From Single-cell Organisms to Mammals. 2016. pag. 177-192
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