INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER, NUTRACEUTICAL ASPECTS

Francesca Rappa, Giovanni Tomasello, Francesco Carini, Angelo Leone, Rosalyn Jurjus, Tarek Bou Assi, Francesca Rappa, Alice Gerges Geagea, Eleonora Trovato, Giovanni Tomasello, Abdo Jurjus

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

Nutraceuticals constitute a group of functional foods that provide added health benefits for various disorders including inflammatory bowel disease (IBD) and colorectal cancer (CCR). The main groups of nutraceuticals include probiotics, prebiotics omega 3 and antioxidants. Studies on nutraceutical showed that this type of food possessed similar properties to drugs but with the benefit of not having side effects. This mini review shows that probiotics and prebiotics, when administered simultaneously with traditional therapies, reduce IBD symptoms and reduce synthesis of enzymes probably involved in colorectal carcinogenesis. Moreover, Omega 3 reduces the synthesis of inflammation mediators and prevenents carcinogenesis through interaction interaction with the signaling pathway NOTCH1/MMP9. Moreover, antioxidant reduce the inflammatory process by inhibiting the synthesis of inflammatory mediators, and inhibit the mechanisms of cell proliferation by inducing apoptosis. In brief, nutraceuticals have gained a huge clinical interest since they could be used along with traditional therapy. Bioavailability studies of nutracetical supplements guarantee a correct intake of the substance by oral administration, a matter which would not have been posible to have entirely with the consumprtion of regular food only.
Lingua originaleEnglish
pagine (da-a)123-129
Numero di pagine7
RivistaDefault journal
Volume11
Stato di pubblicazionePublished - 2016

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Dietary Supplements
Inflammatory Bowel Diseases
Colorectal Neoplasms
Prebiotics
Probiotics
Carcinogenesis
Antioxidants
Food
Inflammation Mediators
Functional Food
Insurance Benefits
Biological Availability
Oral Administration
Cell Proliferation
Apoptosis
Enzymes
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER, NUTRACEUTICAL ASPECTS. / Rappa, Francesca; Tomasello, Giovanni; Carini, Francesco; Leone, Angelo; Jurjus, Rosalyn; Assi, Tarek Bou; Rappa, Francesca; Geagea, Alice Gerges; Trovato, Eleonora; Tomasello, Giovanni; Jurjus, Abdo.

In: Default journal, Vol. 11, 2016, pag. 123-129.

Risultato della ricerca: Article

Rappa, F, Tomasello, G, Carini, F, Leone, A, Jurjus, R, Assi, TB, Rappa, F, Geagea, AG, Trovato, E, Tomasello, G & Jurjus, A 2016, 'INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER, NUTRACEUTICAL ASPECTS', Default journal, vol. 11, pagg. 123-129.
Rappa, Francesca ; Tomasello, Giovanni ; Carini, Francesco ; Leone, Angelo ; Jurjus, Rosalyn ; Assi, Tarek Bou ; Rappa, Francesca ; Geagea, Alice Gerges ; Trovato, Eleonora ; Tomasello, Giovanni ; Jurjus, Abdo. / INFLAMMATORY BOWEL DISEASE AND COLORECTAL CANCER, NUTRACEUTICAL ASPECTS. In: Default journal. 2016 ; Vol. 11. pagg. 123-129.
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AU - Carini, Francesco

AU - Leone, Angelo

AU - Jurjus, Rosalyn

AU - Assi, Tarek Bou

AU - Rappa, Francesca

AU - Geagea, Alice Gerges

AU - Trovato, Eleonora

AU - Tomasello, Giovanni

AU - Jurjus, Abdo

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AB - Nutraceuticals constitute a group of functional foods that provide added health benefits for various disorders including inflammatory bowel disease (IBD) and colorectal cancer (CCR). The main groups of nutraceuticals include probiotics, prebiotics omega 3 and antioxidants. Studies on nutraceutical showed that this type of food possessed similar properties to drugs but with the benefit of not having side effects. This mini review shows that probiotics and prebiotics, when administered simultaneously with traditional therapies, reduce IBD symptoms and reduce synthesis of enzymes probably involved in colorectal carcinogenesis. Moreover, Omega 3 reduces the synthesis of inflammation mediators and prevenents carcinogenesis through interaction interaction with the signaling pathway NOTCH1/MMP9. Moreover, antioxidant reduce the inflammatory process by inhibiting the synthesis of inflammatory mediators, and inhibit the mechanisms of cell proliferation by inducing apoptosis. In brief, nutraceuticals have gained a huge clinical interest since they could be used along with traditional therapy. Bioavailability studies of nutracetical supplements guarantee a correct intake of the substance by oral administration, a matter which would not have been posible to have entirely with the consumprtion of regular food only.

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