INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?

Attilio Ignazio Lo Monte, Giovanni Tomasello, Emanuele Sinagra, Francesco Cappello, Dario Raimondo, Giancarlo Pompei, Aroldo Gabriele Rizzo, Emanuele Sinagra, Georgios Amvrosiadis, Gaetano Cristian Morreale, Francesca Rossi

Risultato della ricerca: Article

33 Citazioni (Scopus)

Abstract

Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.
Lingua originaleEnglish
pagine (da-a)2242-2255
Numero di pagine14
RivistaWorld Journal of Gastroenterology
Volume7
Stato di pubblicazionePublished - 2016

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Irritable Bowel Syndrome
Inflammation
Therapeutics
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Clinical Trials
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All Science Journal Classification (ASJC) codes

  • Gastroenterology

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INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET? / Lo Monte, Attilio Ignazio; Tomasello, Giovanni; Sinagra, Emanuele; Cappello, Francesco; Raimondo, Dario; Pompei, Giancarlo; Rizzo, Aroldo Gabriele; Sinagra, Emanuele; Amvrosiadis, Georgios; Morreale, Gaetano Cristian; Rossi, Francesca.

In: World Journal of Gastroenterology, Vol. 7, 2016, pag. 2242-2255.

Risultato della ricerca: Article

Lo Monte, AI, Tomasello, G, Sinagra, E, Cappello, F, Raimondo, D, Pompei, G, Rizzo, AG, Sinagra, E, Amvrosiadis, G, Morreale, GC & Rossi, F 2016, 'INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?', World Journal of Gastroenterology, vol. 7, pagg. 2242-2255.
Lo Monte, Attilio Ignazio ; Tomasello, Giovanni ; Sinagra, Emanuele ; Cappello, Francesco ; Raimondo, Dario ; Pompei, Giancarlo ; Rizzo, Aroldo Gabriele ; Sinagra, Emanuele ; Amvrosiadis, Georgios ; Morreale, Gaetano Cristian ; Rossi, Francesca. / INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?. In: World Journal of Gastroenterology. 2016 ; Vol. 7. pagg. 2242-2255.
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title = "INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?",
abstract = "Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.",
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AU - Lo Monte, Attilio Ignazio

AU - Tomasello, Giovanni

AU - Sinagra, Emanuele

AU - Cappello, Francesco

AU - Raimondo, Dario

AU - Pompei, Giancarlo

AU - Rizzo, Aroldo Gabriele

AU - Sinagra, Emanuele

AU - Amvrosiadis, Georgios

AU - Morreale, Gaetano Cristian

AU - Rossi, Francesca

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AB - Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.

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