INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?

Emanuele Sinagra, Giovanni Tomasello, Attilio Ignazio Lo Monte, Francesco Cappello, Dario Raimondo, Giancarlo Pompei, Aroldo Gabriele Rizzo, Emanuele Sinagra, Georgios Amvrosiadis, Gaetano Cristian Morreale, Francesca Rossi

Risultato della ricerca: Article

33 Citazioni (Scopus)

Abstract

Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.
Lingua originaleEnglish
pagine (da-a)2242-2255
Numero di pagine14
RivistaDefault journal
Volume7
Stato di pubblicazionePublished - 2016

Fingerprint

Irritable Bowel Syndrome
Inflammation
Therapeutics
Libraries
Publications
Clinical Trials
Safety
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cita questo

INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET? / Sinagra, Emanuele; Tomasello, Giovanni; Lo Monte, Attilio Ignazio; Cappello, Francesco; Raimondo, Dario; Pompei, Giancarlo; Rizzo, Aroldo Gabriele; Sinagra, Emanuele; Amvrosiadis, Georgios; Morreale, Gaetano Cristian; Rossi, Francesca.

In: Default journal, Vol. 7, 2016, pag. 2242-2255.

Risultato della ricerca: Article

Sinagra, E, Tomasello, G, Lo Monte, AI, Cappello, F, Raimondo, D, Pompei, G, Rizzo, AG, Sinagra, E, Amvrosiadis, G, Morreale, GC & Rossi, F 2016, 'INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?', Default journal, vol. 7, pagg. 2242-2255.
Sinagra, Emanuele ; Tomasello, Giovanni ; Lo Monte, Attilio Ignazio ; Cappello, Francesco ; Raimondo, Dario ; Pompei, Giancarlo ; Rizzo, Aroldo Gabriele ; Sinagra, Emanuele ; Amvrosiadis, Georgios ; Morreale, Gaetano Cristian ; Rossi, Francesca. / INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?. In: Default journal. 2016 ; Vol. 7. pagg. 2242-2255.
@article{27014dfe58f24cdeb2449d532b2b104f,
title = "INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?",
abstract = "Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.",
author = "Emanuele Sinagra and Giovanni Tomasello and {Lo Monte}, {Attilio Ignazio} and Francesco Cappello and Dario Raimondo and Giancarlo Pompei and Rizzo, {Aroldo Gabriele} and Emanuele Sinagra and Georgios Amvrosiadis and Morreale, {Gaetano Cristian} and Francesca Rossi",
year = "2016",
language = "English",
volume = "7",
pages = "2242--2255",
journal = "Default journal",

}

TY - JOUR

T1 - INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET?

AU - Sinagra, Emanuele

AU - Tomasello, Giovanni

AU - Lo Monte, Attilio Ignazio

AU - Cappello, Francesco

AU - Raimondo, Dario

AU - Pompei, Giancarlo

AU - Rizzo, Aroldo Gabriele

AU - Sinagra, Emanuele

AU - Amvrosiadis, Georgios

AU - Morreale, Gaetano Cristian

AU - Rossi, Francesca

PY - 2016

Y1 - 2016

N2 - Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.

AB - Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications decribing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanism underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.

UR - http://hdl.handle.net/10447/168481

M3 - Article

VL - 7

SP - 2242

EP - 2255

JO - Default journal

JF - Default journal

ER -