INCREASED LEVELS OF C-REACTIVE PROTEIN AND FIBRINOGEN INFLUENCE THE RISK OF VASCULAR EVENTS IN PATIENTS WITH NIDDM

Egle Corrado, Salvatore Novo, Salvatore Novo, Giuseppe Coppola, Lo Coco, Rosalba Tantillo, Egle Corrado, Giuseppe Coppola, Ida Maria Muratori, Lucio Lo Coco, Rosalba Tantillo

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42 Citazioni (Scopus)

Abstract

AIM: To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes.METHODS: We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death.RESULTS: During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events.CONCLUSION: Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.
Lingua originaleEnglish
pagine (da-a)16-20
Numero di pagine5
RivistaINTERNATIONAL JOURNAL OF CARDIOLOGY
Volume106
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

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