Incorporation of an antibiotic in poly(lactic acid) and polypropylene by melt processing

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5 Citazioni (Scopus)

Abstract

Purpose: In this work an antibiotic, ciprofloxacin (CFX), was incorporated into 2 different polymeric matrices, poly(lactic acid) (PLA) and polypropylene (PP), to provide them with antimicrobial properties. The influence of CFX content on release kinetics and on antimicrobial and mechanical properties was evaluated. Methods: CFX was incorporated into both the polymers by melt mixing. Results: The effect of CFX incorporation was found to strongly depend on which polymer matrix was used. In particular, the antimicrobial tests revealed that PLA samples containing CFX produced no inhibition zone and only a slight antibacterial activity was observed when the highest concentration of CFX was added to PLA. On the contrary, PP-based materials incorporating CFX, even those containing the smallest concentration of antibiotic, showed antimicrobial activity. These results were found to be in good agreement with the evaluation of the CFX release. Conclusions: The negative findings of PLA-based systems are attributed to degradation phenomena that occur during the melt processing, involving some interaction between PLA and CFX. A proposed reaction mechanism between CFX and PLA occurring in the melt is presented.
Lingua originaleEnglish
pagine (da-a)e240-e247
Numero di pagine8
RivistaJOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
Volume14
Stato di pubblicazionePublished - 2016

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Polypropylenes
Antibiotics
Lactic acid
Ciprofloxacin
Anti-Bacterial Agents
Processing
Polymer matrix
Degradation
Mechanical properties
Kinetics
Polymers
poly(lactic acid)

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering
  • Biomaterials
  • Biophysics

Cita questo

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title = "Incorporation of an antibiotic in poly(lactic acid) and polypropylene by melt processing",
abstract = "Purpose: In this work an antibiotic, ciprofloxacin (CFX), was incorporated into 2 different polymeric matrices, poly(lactic acid) (PLA) and polypropylene (PP), to provide them with antimicrobial properties. The influence of CFX content on release kinetics and on antimicrobial and mechanical properties was evaluated. Methods: CFX was incorporated into both the polymers by melt mixing. Results: The effect of CFX incorporation was found to strongly depend on which polymer matrix was used. In particular, the antimicrobial tests revealed that PLA samples containing CFX produced no inhibition zone and only a slight antibacterial activity was observed when the highest concentration of CFX was added to PLA. On the contrary, PP-based materials incorporating CFX, even those containing the smallest concentration of antibiotic, showed antimicrobial activity. These results were found to be in good agreement with the evaluation of the CFX release. Conclusions: The negative findings of PLA-based systems are attributed to degradation phenomena that occur during the melt processing, involving some interaction between PLA and CFX. A proposed reaction mechanism between CFX and PLA occurring in the melt is presented.",
keywords = "Antimicrobial properties; Ciprofloxacin; Degradation; Poly(lactic acid) (PLA); Polypropylene (PP); Biophysics; Bioengineering; Biomedical Engineering; Biomaterials",
author = "Roberto Scaffaro and Andrea Maio and Luigi Botta and Giuseppe Gallo",
year = "2016",
language = "English",
volume = "14",
pages = "e240--e247",
journal = "Journal of Applied Biomaterials and Functional Materials",
issn = "2280-8000",
publisher = "SAGE Publications Inc.",

}

TY - JOUR

T1 - Incorporation of an antibiotic in poly(lactic acid) and polypropylene by melt processing

AU - Scaffaro, Roberto

AU - Maio, Andrea

AU - Botta, Luigi

AU - Gallo, Giuseppe

PY - 2016

Y1 - 2016

N2 - Purpose: In this work an antibiotic, ciprofloxacin (CFX), was incorporated into 2 different polymeric matrices, poly(lactic acid) (PLA) and polypropylene (PP), to provide them with antimicrobial properties. The influence of CFX content on release kinetics and on antimicrobial and mechanical properties was evaluated. Methods: CFX was incorporated into both the polymers by melt mixing. Results: The effect of CFX incorporation was found to strongly depend on which polymer matrix was used. In particular, the antimicrobial tests revealed that PLA samples containing CFX produced no inhibition zone and only a slight antibacterial activity was observed when the highest concentration of CFX was added to PLA. On the contrary, PP-based materials incorporating CFX, even those containing the smallest concentration of antibiotic, showed antimicrobial activity. These results were found to be in good agreement with the evaluation of the CFX release. Conclusions: The negative findings of PLA-based systems are attributed to degradation phenomena that occur during the melt processing, involving some interaction between PLA and CFX. A proposed reaction mechanism between CFX and PLA occurring in the melt is presented.

AB - Purpose: In this work an antibiotic, ciprofloxacin (CFX), was incorporated into 2 different polymeric matrices, poly(lactic acid) (PLA) and polypropylene (PP), to provide them with antimicrobial properties. The influence of CFX content on release kinetics and on antimicrobial and mechanical properties was evaluated. Methods: CFX was incorporated into both the polymers by melt mixing. Results: The effect of CFX incorporation was found to strongly depend on which polymer matrix was used. In particular, the antimicrobial tests revealed that PLA samples containing CFX produced no inhibition zone and only a slight antibacterial activity was observed when the highest concentration of CFX was added to PLA. On the contrary, PP-based materials incorporating CFX, even those containing the smallest concentration of antibiotic, showed antimicrobial activity. These results were found to be in good agreement with the evaluation of the CFX release. Conclusions: The negative findings of PLA-based systems are attributed to degradation phenomena that occur during the melt processing, involving some interaction between PLA and CFX. A proposed reaction mechanism between CFX and PLA occurring in the melt is presented.

KW - Antimicrobial properties; Ciprofloxacin; Degradation; Poly(lactic acid) (PLA); Polypropylene (PP); Biophysics; Bioengineering; Biomedical Engineering; Biomaterials

UR - http://hdl.handle.net/10447/202034

UR - http://www.jab-fm.com/Attach/2d66672d-c1db-476b-a100-c8cc8a22ab35/9b1910ac-82f7-406f-a590-3675cfe6592c

M3 - Article

VL - 14

SP - e240-e247

JO - Journal of Applied Biomaterials and Functional Materials

JF - Journal of Applied Biomaterials and Functional Materials

SN - 2280-8000

ER -