Incidence of new foci of hepatocellular carcinoma after radiofrequency ablation: role of multidetector CT

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Abstract

Purpose. The authors sought to assess the incidence of new foci of hepatocellular carcinoma (HCC) using multidetector computed tomography (MDCT) in patients treated with radiofrequency ablation (RFA).Materials and methods. Two readers retrospectively reviewed by consensus the follow-up MDCT studies of 125 patients (88 men and 37 women; mean age 68 years) with 141 HCCs (size 1–5.2 cm; mean 2.2 cm) treated with RFA. MDCT follow-up was performed at 1 and 3 months and every 6–12 months thereafter. Reviewers assessed: (1) the presence of new HCC foci in the same liver segment or in a different segment; (2) complete or incomplete tumor ablation; (3) tumour progression.Results. A total of 113 new HCCs (size 0.7–4.8 cm; mean1.7 cm) were detected in 69/125 (55.2%) patients (meanfollow-up 30.38±19.14 months). Of these, 86 (76.1%) newHCCs were multiple (p<0.0001), and 92 (81.4%) occurredin a different segment from that of the treated HCC(p<0.0001). New HCCs were observed in the first12 months, between 12 and 24 months and after 24months in 31/69 (44.9%), 24/69 (34.8%) and 14/69(20.3%) patients, respectively (p=0.175). Mean diseasefreeinterval was 16.1±16.31 (range 1–52) months.Complete tumour ablation was achieved in 132/141(93.6%) treated HCCs, and tumour progression occurredin 29/141 (20.6%) cases.Conclusions. In patients with RFA-treated HCCs, MDCTfollow-up revealed a high incidence of new HCCs, evenafter 1 year of follow-up. The new foci tended to be multiple and located in a liver segment different from thatof the previously treated nodules.
Lingua originaleEnglish
pagine (da-a)739-748
Numero di pagine9
RivistaDefault journal
Volume117
Stato di pubblicazionePublished - 2012

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Hepatocellular Carcinoma
Multidetector Computed Tomography
Incidence
Neoplasms
Liver

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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@article{74954bc66c204b39ba9bd188c45196e9,
title = "Incidence of new foci of hepatocellular carcinoma after radiofrequency ablation: role of multidetector CT",
abstract = "Purpose. The authors sought to assess the incidence of new foci of hepatocellular carcinoma (HCC) using multidetector computed tomography (MDCT) in patients treated with radiofrequency ablation (RFA).Materials and methods. Two readers retrospectively reviewed by consensus the follow-up MDCT studies of 125 patients (88 men and 37 women; mean age 68 years) with 141 HCCs (size 1–5.2 cm; mean 2.2 cm) treated with RFA. MDCT follow-up was performed at 1 and 3 months and every 6–12 months thereafter. Reviewers assessed: (1) the presence of new HCC foci in the same liver segment or in a different segment; (2) complete or incomplete tumor ablation; (3) tumour progression.Results. A total of 113 new HCCs (size 0.7–4.8 cm; mean1.7 cm) were detected in 69/125 (55.2{\%}) patients (meanfollow-up 30.38±19.14 months). Of these, 86 (76.1{\%}) newHCCs were multiple (p<0.0001), and 92 (81.4{\%}) occurredin a different segment from that of the treated HCC(p<0.0001). New HCCs were observed in the first12 months, between 12 and 24 months and after 24months in 31/69 (44.9{\%}), 24/69 (34.8{\%}) and 14/69(20.3{\%}) patients, respectively (p=0.175). Mean diseasefreeinterval was 16.1±16.31 (range 1–52) months.Complete tumour ablation was achieved in 132/141(93.6{\%}) treated HCCs, and tumour progression occurredin 29/141 (20.6{\%}) cases.Conclusions. In patients with RFA-treated HCCs, MDCTfollow-up revealed a high incidence of new HCCs, evenafter 1 year of follow-up. The new foci tended to be multiple and located in a liver segment different from thatof the previously treated nodules.",
author = "Adele Taibbi and Roberto Lagalla and Bartolotta, {Tommaso Vincenzo} and Domenica Matranga and Massimo Midiri and Luigi Sandonato and Serena Asta",
year = "2012",
language = "English",
volume = "117",
pages = "739--748",
journal = "Default journal",

}

TY - JOUR

T1 - Incidence of new foci of hepatocellular carcinoma after radiofrequency ablation: role of multidetector CT

AU - Taibbi, Adele

AU - Lagalla, Roberto

AU - Bartolotta, Tommaso Vincenzo

AU - Matranga, Domenica

AU - Midiri, Massimo

AU - Sandonato, Luigi

AU - Asta, Serena

PY - 2012

Y1 - 2012

N2 - Purpose. The authors sought to assess the incidence of new foci of hepatocellular carcinoma (HCC) using multidetector computed tomography (MDCT) in patients treated with radiofrequency ablation (RFA).Materials and methods. Two readers retrospectively reviewed by consensus the follow-up MDCT studies of 125 patients (88 men and 37 women; mean age 68 years) with 141 HCCs (size 1–5.2 cm; mean 2.2 cm) treated with RFA. MDCT follow-up was performed at 1 and 3 months and every 6–12 months thereafter. Reviewers assessed: (1) the presence of new HCC foci in the same liver segment or in a different segment; (2) complete or incomplete tumor ablation; (3) tumour progression.Results. A total of 113 new HCCs (size 0.7–4.8 cm; mean1.7 cm) were detected in 69/125 (55.2%) patients (meanfollow-up 30.38±19.14 months). Of these, 86 (76.1%) newHCCs were multiple (p<0.0001), and 92 (81.4%) occurredin a different segment from that of the treated HCC(p<0.0001). New HCCs were observed in the first12 months, between 12 and 24 months and after 24months in 31/69 (44.9%), 24/69 (34.8%) and 14/69(20.3%) patients, respectively (p=0.175). Mean diseasefreeinterval was 16.1±16.31 (range 1–52) months.Complete tumour ablation was achieved in 132/141(93.6%) treated HCCs, and tumour progression occurredin 29/141 (20.6%) cases.Conclusions. In patients with RFA-treated HCCs, MDCTfollow-up revealed a high incidence of new HCCs, evenafter 1 year of follow-up. The new foci tended to be multiple and located in a liver segment different from thatof the previously treated nodules.

AB - Purpose. The authors sought to assess the incidence of new foci of hepatocellular carcinoma (HCC) using multidetector computed tomography (MDCT) in patients treated with radiofrequency ablation (RFA).Materials and methods. Two readers retrospectively reviewed by consensus the follow-up MDCT studies of 125 patients (88 men and 37 women; mean age 68 years) with 141 HCCs (size 1–5.2 cm; mean 2.2 cm) treated with RFA. MDCT follow-up was performed at 1 and 3 months and every 6–12 months thereafter. Reviewers assessed: (1) the presence of new HCC foci in the same liver segment or in a different segment; (2) complete or incomplete tumor ablation; (3) tumour progression.Results. A total of 113 new HCCs (size 0.7–4.8 cm; mean1.7 cm) were detected in 69/125 (55.2%) patients (meanfollow-up 30.38±19.14 months). Of these, 86 (76.1%) newHCCs were multiple (p<0.0001), and 92 (81.4%) occurredin a different segment from that of the treated HCC(p<0.0001). New HCCs were observed in the first12 months, between 12 and 24 months and after 24months in 31/69 (44.9%), 24/69 (34.8%) and 14/69(20.3%) patients, respectively (p=0.175). Mean diseasefreeinterval was 16.1±16.31 (range 1–52) months.Complete tumour ablation was achieved in 132/141(93.6%) treated HCCs, and tumour progression occurredin 29/141 (20.6%) cases.Conclusions. In patients with RFA-treated HCCs, MDCTfollow-up revealed a high incidence of new HCCs, evenafter 1 year of follow-up. The new foci tended to be multiple and located in a liver segment different from thatof the previously treated nodules.

UR - http://hdl.handle.net/10447/78215

M3 - Article

VL - 117

SP - 739

EP - 748

JO - Default journal

JF - Default journal

ER -