Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study

Roberto Monastero, Vincenzo Restivo, Antonina Luca, Giovanni Mostile, Calogero Edoardo Cicero, Mario Zappia, Alessandra Nicoletti, Laura Pilati, Marco Davi', Roberta Baschi

Risultato della ricerca: Article

4 Citazioni (Scopus)

Abstract

Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6%) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3%) of the 84 PD-NC at baseline developed MCI and 4 (4.8%) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95% CI 124.7-262.3). At multivariate analysis a negative association between education and MCI development at follow-up was observed (HR 0.37, 95% CI 0.15-0.89; p = 0.03). The incidence rate of dementia was 24.3/1000 pyar (95% CI 7.7-58.5). Out of 55 PD-MCI patients at baseline, 14 (25.4%) converted to PDD, giving an incidence rate of 123.5/1000 pyar (95% CI 70.3-202.2). A five time increased risk of PDD was found in PD patients with MCI at baseline (RR 5.09, 95% CI 1.60-21.4). Conclusion: Our study supports the relevant role of PD-MCI in predicting PDD and underlines the importance of education in reducing the risk of cognitive impairment.
Lingua originaleEnglish
pagine (da-a)21-
Numero di pagine12
RivistaFrontiers in Aging Neuroscience
Volume10
Stato di pubblicazionePublished - 2019

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Parkinson Disease
Dementia
Incidence
Cognitive Dysfunction
Demography
Education
Proportional Hazards Models
Cognition
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Ageing
  • Cognitive Neuroscience

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Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study. / Monastero, Roberto; Restivo, Vincenzo; Luca, Antonina; Mostile, Giovanni; Cicero, Calogero Edoardo; Zappia, Mario; Nicoletti, Alessandra; Pilati, Laura; Davi', Marco; Baschi, Roberta.

In: Frontiers in Aging Neuroscience, Vol. 10, 2019, pag. 21-.

Risultato della ricerca: Article

Monastero, R, Restivo, V, Luca, A, Mostile, G, Cicero, CE, Zappia, M, Nicoletti, A, Pilati, L, Davi', M & Baschi, R 2019, 'Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study', Frontiers in Aging Neuroscience, vol. 10, pagg. 21-.
Monastero, Roberto ; Restivo, Vincenzo ; Luca, Antonina ; Mostile, Giovanni ; Cicero, Calogero Edoardo ; Zappia, Mario ; Nicoletti, Alessandra ; Pilati, Laura ; Davi', Marco ; Baschi, Roberta. / Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study. In: Frontiers in Aging Neuroscience. 2019 ; Vol. 10. pagg. 21-.
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title = "Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study",
abstract = "Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6{\%}) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3{\%}) of the 84 PD-NC at baseline developed MCI and 4 (4.8{\%}) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95{\%} CI 124.7-262.3). At multivariate analysis a negative association between education and MCI development at follow-up was observed (HR 0.37, 95{\%} CI 0.15-0.89; p = 0.03). The incidence rate of dementia was 24.3/1000 pyar (95{\%} CI 7.7-58.5). Out of 55 PD-MCI patients at baseline, 14 (25.4{\%}) converted to PDD, giving an incidence rate of 123.5/1000 pyar (95{\%} CI 70.3-202.2). A five time increased risk of PDD was found in PD patients with MCI at baseline (RR 5.09, 95{\%} CI 1.60-21.4). Conclusion: Our study supports the relevant role of PD-MCI in predicting PDD and underlines the importance of education in reducing the risk of cognitive impairment.",
author = "Roberto Monastero and Vincenzo Restivo and Antonina Luca and Giovanni Mostile and Cicero, {Calogero Edoardo} and Mario Zappia and Alessandra Nicoletti and Laura Pilati and Marco Davi' and Roberta Baschi",
year = "2019",
language = "English",
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pages = "21--",
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TY - JOUR

T1 - Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study

AU - Monastero, Roberto

AU - Restivo, Vincenzo

AU - Luca, Antonina

AU - Mostile, Giovanni

AU - Cicero, Calogero Edoardo

AU - Zappia, Mario

AU - Nicoletti, Alessandra

AU - Pilati, Laura

AU - Davi', Marco

AU - Baschi, Roberta

PY - 2019

Y1 - 2019

N2 - Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6%) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3%) of the 84 PD-NC at baseline developed MCI and 4 (4.8%) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95% CI 124.7-262.3). At multivariate analysis a negative association between education and MCI development at follow-up was observed (HR 0.37, 95% CI 0.15-0.89; p = 0.03). The incidence rate of dementia was 24.3/1000 pyar (95% CI 7.7-58.5). Out of 55 PD-MCI patients at baseline, 14 (25.4%) converted to PDD, giving an incidence rate of 123.5/1000 pyar (95% CI 70.3-202.2). A five time increased risk of PDD was found in PD patients with MCI at baseline (RR 5.09, 95% CI 1.60-21.4). Conclusion: Our study supports the relevant role of PD-MCI in predicting PDD and underlines the importance of education in reducing the risk of cognitive impairment.

AB - Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6%) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3%) of the 84 PD-NC at baseline developed MCI and 4 (4.8%) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95% CI 124.7-262.3). At multivariate analysis a negative association between education and MCI development at follow-up was observed (HR 0.37, 95% CI 0.15-0.89; p = 0.03). The incidence rate of dementia was 24.3/1000 pyar (95% CI 7.7-58.5). Out of 55 PD-MCI patients at baseline, 14 (25.4%) converted to PDD, giving an incidence rate of 123.5/1000 pyar (95% CI 70.3-202.2). A five time increased risk of PDD was found in PD patients with MCI at baseline (RR 5.09, 95% CI 1.60-21.4). Conclusion: Our study supports the relevant role of PD-MCI in predicting PDD and underlines the importance of education in reducing the risk of cognitive impairment.

UR - http://hdl.handle.net/10447/390490

UR - https://www.frontiersin.org/journals/aging-neuroscience#

M3 - Article

VL - 10

SP - 21-

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

ER -