Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study

Roberto Monastero, Vincenzo Restivo, Antonina Luca, Giovanni Mostile, Calogero Edoardo Cicero, Mario Zappia, Alessandra Nicoletti, Laura Pilati, Marco Davi', Roberta Baschi

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6%) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3%) of the 84 PD-NC at baseline developed MCI and 4 (4.8%) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95% CI 124.7-262.3). At multivariate analysis a negative association between education and MCI development at follow-up was observed (HR 0.37, 95% CI 0.15-0.89; p = 0.03). The incidence rate of dementia was 24.3/1000 pyar (95% CI 7.7-58.5). Out of 55 PD-MCI patients at baseline, 14 (25.4%) converted to PDD, giving an incidence rate of 123.5/1000 pyar (95% CI 70.3-202.2). A five time increased risk of PDD was found in PD patients with MCI at baseline (RR 5.09, 95% CI 1.60-21.4). Conclusion: Our study supports the relevant role of PD-MCI in predicting PDD and underlines the importance of education in reducing the risk of cognitive impairment.
Lingua originaleEnglish
pagine (da-a)21-
Numero di pagine12
RivistaFrontiers in Aging Neuroscience
Volume10
Stato di pubblicazionePublished - 2019

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Ageing
  • Cognitive Neuroscience

Cita questo

Monastero, R., Restivo, V., Luca, A., Mostile, G., Cicero, C. E., Zappia, M., Nicoletti, A., Pilati, L., Davi', M., & Baschi, R. (2019). Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study. Frontiers in Aging Neuroscience, 10, 21-.