Incidence of Crohn's disease and Card 15 mutation in a small township in Sicily

Valeria Criscuoli, Mario Cottone, Mario Cottone, Mattaliano, Maria Concetta Renda, Aurelio Maggio, Walter Fries, Angelo Casa', Daniela Scimeca, Irene Modesto, Silvana Maisano

Risultato della ricerca: Article

20 Citazioni (Scopus)

Abstract

Background: The incidence of Crohn's disease (CD) has been shown to be lower in Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations for Mediterranean area are very scant. Aim: To determine the incidence of CD from 1979 to 2002 in a township in Sicily together with the allele frequency of NOD2/CARD15 mutations in patients, family members and controls, and to determine the allele frequency of these mutations in sporadic CD from other areas of Sicily in comparison with a control population. Methods: Casteltermini is a small town close to Agrigento (Sicily) with a population of 9,130 inhabitants. All the diagnoses of inflammatory bowel disease (IBD) made from 1979 to 2002 were obtained through the local health authority. NOD2/CARD15 mutations were studied in 23 out of the 29 patients with CD in Casteltermini, in 60 family members and in 64 controls. NOD2/CARD15 was also studied in 80 sporadic cases of CD disease among Sicilians outside Casteltermini and 118 healthy controls. Results: From 1979 to 2002, 29 patients with CD and 13 patients with ulcerative colitis (UC) were registered. The 6-year mean incidence of CD ranged from 8.0 to 17 new cases for every 100,000 inhabitants, whereas the mean incidence of UC ranged from five new cases to 7.8 for every 100,000 inhabitants. The allele frequencies of NOD2/CARD15 mutations (L1007finsC, G908R, R702W) were 8.7, 4.3 and 8.7%, respectively, in CD cases; 5.0, 4.2 and 3.1% in family members; 1.6, 2.3 and 3.1% in controls. In sporadic Sicilian CD patients outside Casteltermini the allele frequency was 7.5, 8.1, 6.2% whereas in control population it was 3.3, 1.6, 1.6%. Conclusions: A high incidence of CD compared with UC was observed in this small town in Southern Italy. The frequency of NOD2/CARD15 mutations in CD is similar to other Caucasian population studied so far.
Lingua originaleEnglish
pagine (da-a)887-892
Numero di pagine6
RivistaEuropean Journal of Epidemiology
Volume21
Stato di pubblicazionePublished - 2006

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Sicily
Crohn Disease
Mutation
Incidence
Gene Frequency
Ulcerative Colitis
Population
Inflammatory Bowel Diseases
Italy

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cita questo

Criscuoli, V., Cottone, M., Cottone, M., Mattaliano, Renda, M. C., Maggio, A., ... Maisano, S. (2006). Incidence of Crohn's disease and Card 15 mutation in a small township in Sicily. European Journal of Epidemiology, 21, 887-892.

Incidence of Crohn's disease and Card 15 mutation in a small township in Sicily. / Criscuoli, Valeria; Cottone, Mario; Cottone, Mario; Mattaliano; Renda, Maria Concetta; Maggio, Aurelio; Fries, Walter; Casa', Angelo; Scimeca, Daniela; Modesto, Irene; Maisano, Silvana.

In: European Journal of Epidemiology, Vol. 21, 2006, pag. 887-892.

Risultato della ricerca: Article

Criscuoli, V, Cottone, M, Cottone, M, Mattaliano, Renda, MC, Maggio, A, Fries, W, Casa', A, Scimeca, D, Modesto, I & Maisano, S 2006, 'Incidence of Crohn's disease and Card 15 mutation in a small township in Sicily', European Journal of Epidemiology, vol. 21, pagg. 887-892.
Criscuoli, Valeria ; Cottone, Mario ; Cottone, Mario ; Mattaliano ; Renda, Maria Concetta ; Maggio, Aurelio ; Fries, Walter ; Casa', Angelo ; Scimeca, Daniela ; Modesto, Irene ; Maisano, Silvana. / Incidence of Crohn's disease and Card 15 mutation in a small township in Sicily. In: European Journal of Epidemiology. 2006 ; Vol. 21. pagg. 887-892.
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title = "Incidence of Crohn's disease and Card 15 mutation in a small township in Sicily",
abstract = "Background: The incidence of Crohn's disease (CD) has been shown to be lower in Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations for Mediterranean area are very scant. Aim: To determine the incidence of CD from 1979 to 2002 in a township in Sicily together with the allele frequency of NOD2/CARD15 mutations in patients, family members and controls, and to determine the allele frequency of these mutations in sporadic CD from other areas of Sicily in comparison with a control population. Methods: Casteltermini is a small town close to Agrigento (Sicily) with a population of 9,130 inhabitants. All the diagnoses of inflammatory bowel disease (IBD) made from 1979 to 2002 were obtained through the local health authority. NOD2/CARD15 mutations were studied in 23 out of the 29 patients with CD in Casteltermini, in 60 family members and in 64 controls. NOD2/CARD15 was also studied in 80 sporadic cases of CD disease among Sicilians outside Casteltermini and 118 healthy controls. Results: From 1979 to 2002, 29 patients with CD and 13 patients with ulcerative colitis (UC) were registered. The 6-year mean incidence of CD ranged from 8.0 to 17 new cases for every 100,000 inhabitants, whereas the mean incidence of UC ranged from five new cases to 7.8 for every 100,000 inhabitants. The allele frequencies of NOD2/CARD15 mutations (L1007finsC, G908R, R702W) were 8.7, 4.3 and 8.7{\%}, respectively, in CD cases; 5.0, 4.2 and 3.1{\%} in family members; 1.6, 2.3 and 3.1{\%} in controls. In sporadic Sicilian CD patients outside Casteltermini the allele frequency was 7.5, 8.1, 6.2{\%} whereas in control population it was 3.3, 1.6, 1.6{\%}. Conclusions: A high incidence of CD compared with UC was observed in this small town in Southern Italy. The frequency of NOD2/CARD15 mutations in CD is similar to other Caucasian population studied so far.",
author = "Valeria Criscuoli and Mario Cottone and Mario Cottone and Mattaliano and Renda, {Maria Concetta} and Aurelio Maggio and Walter Fries and Angelo Casa' and Daniela Scimeca and Irene Modesto and Silvana Maisano",
year = "2006",
language = "English",
volume = "21",
pages = "887--892",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
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TY - JOUR

T1 - Incidence of Crohn's disease and Card 15 mutation in a small township in Sicily

AU - Criscuoli, Valeria

AU - Cottone, Mario

AU - Cottone, Mario

AU - Mattaliano, null

AU - Renda, Maria Concetta

AU - Maggio, Aurelio

AU - Fries, Walter

AU - Casa', Angelo

AU - Scimeca, Daniela

AU - Modesto, Irene

AU - Maisano, Silvana

PY - 2006

Y1 - 2006

N2 - Background: The incidence of Crohn's disease (CD) has been shown to be lower in Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations for Mediterranean area are very scant. Aim: To determine the incidence of CD from 1979 to 2002 in a township in Sicily together with the allele frequency of NOD2/CARD15 mutations in patients, family members and controls, and to determine the allele frequency of these mutations in sporadic CD from other areas of Sicily in comparison with a control population. Methods: Casteltermini is a small town close to Agrigento (Sicily) with a population of 9,130 inhabitants. All the diagnoses of inflammatory bowel disease (IBD) made from 1979 to 2002 were obtained through the local health authority. NOD2/CARD15 mutations were studied in 23 out of the 29 patients with CD in Casteltermini, in 60 family members and in 64 controls. NOD2/CARD15 was also studied in 80 sporadic cases of CD disease among Sicilians outside Casteltermini and 118 healthy controls. Results: From 1979 to 2002, 29 patients with CD and 13 patients with ulcerative colitis (UC) were registered. The 6-year mean incidence of CD ranged from 8.0 to 17 new cases for every 100,000 inhabitants, whereas the mean incidence of UC ranged from five new cases to 7.8 for every 100,000 inhabitants. The allele frequencies of NOD2/CARD15 mutations (L1007finsC, G908R, R702W) were 8.7, 4.3 and 8.7%, respectively, in CD cases; 5.0, 4.2 and 3.1% in family members; 1.6, 2.3 and 3.1% in controls. In sporadic Sicilian CD patients outside Casteltermini the allele frequency was 7.5, 8.1, 6.2% whereas in control population it was 3.3, 1.6, 1.6%. Conclusions: A high incidence of CD compared with UC was observed in this small town in Southern Italy. The frequency of NOD2/CARD15 mutations in CD is similar to other Caucasian population studied so far.

AB - Background: The incidence of Crohn's disease (CD) has been shown to be lower in Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations for Mediterranean area are very scant. Aim: To determine the incidence of CD from 1979 to 2002 in a township in Sicily together with the allele frequency of NOD2/CARD15 mutations in patients, family members and controls, and to determine the allele frequency of these mutations in sporadic CD from other areas of Sicily in comparison with a control population. Methods: Casteltermini is a small town close to Agrigento (Sicily) with a population of 9,130 inhabitants. All the diagnoses of inflammatory bowel disease (IBD) made from 1979 to 2002 were obtained through the local health authority. NOD2/CARD15 mutations were studied in 23 out of the 29 patients with CD in Casteltermini, in 60 family members and in 64 controls. NOD2/CARD15 was also studied in 80 sporadic cases of CD disease among Sicilians outside Casteltermini and 118 healthy controls. Results: From 1979 to 2002, 29 patients with CD and 13 patients with ulcerative colitis (UC) were registered. The 6-year mean incidence of CD ranged from 8.0 to 17 new cases for every 100,000 inhabitants, whereas the mean incidence of UC ranged from five new cases to 7.8 for every 100,000 inhabitants. The allele frequencies of NOD2/CARD15 mutations (L1007finsC, G908R, R702W) were 8.7, 4.3 and 8.7%, respectively, in CD cases; 5.0, 4.2 and 3.1% in family members; 1.6, 2.3 and 3.1% in controls. In sporadic Sicilian CD patients outside Casteltermini the allele frequency was 7.5, 8.1, 6.2% whereas in control population it was 3.3, 1.6, 1.6%. Conclusions: A high incidence of CD compared with UC was observed in this small town in Southern Italy. The frequency of NOD2/CARD15 mutations in CD is similar to other Caucasian population studied so far.

UR - http://hdl.handle.net/10447/33680

M3 - Article

VL - 21

SP - 887

EP - 892

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

ER -