INCIDENCE OF AMYOTROPHIC LATERAL SCLEROSIS IN SICILY: A POPULATION BASED STUDY.

Rossella Spataro, Marco D'Amelio, Vincenzo La Bella, Paolo Ragonese, Paolo Aridon, Giovanni Savettieri, Gianluigi Mancardi, Francesco Marrosu, Francesca Trojsi, Kalliopi Marinou, Cristina Moglia, Valeria Piras, Ilaria Bartolomei, Giuseppe Marangi, Stefania Cammarosano, Amelia Conte, Giuseppe Lauria Pinter, Marco Luigetti, Alan E. Renton, Irene OssolaSerena Lattante, Yevgeniya Abramzon, Gianluca Floris, Claudia Ricci, Emanuela Costantino, William Sproviero, Leslie D. Parish, Simona Portaro, Lucia Ulgheri, Carla Pani, Pharm.D., Anna Laiola, Antonio Canosa, Laura Papetti, Paolo Volanti, Carmelo Rodolico, Giuseppe Fuda, Francesco Izzo, Paola Cossu, Maura Brunetti, Patrizia Sola, Sara Gallo, Maria Rosaria Monsurrò, Andrea Calvo, Jessica Mandrioli, Elisa Majounie, Anna Ticca, Giuseppe Borghero, Paola Origone, Claudia Caponnetto, Maura Pugliatti, Stefania Battistini, Bryan J. Traynor, Mario Sabatelli, Maria Rita Murru, Giuliana Solinas, Francesca Luisa Conforti, Marcella Zollino, Gabriella Restagno, Antonino Cannas, Paola Mandich, Isabella Simone, Fabrizio Pisano, Giancarlo Logroscino, Silvana Penco, Andrea Calvo, Adriano Chiò, Maria Giovanna Marrosu, Massimo Corbo, Fabrizio Salvi, Gabriele Mora, Aldo Quattrone, Fabio Giannini, Gioacchino Tedeschi, Antonio Gambardella, Christian Lunetta, Maria Alessandra Sotgiu, Alfonsa Claudia Taiello

Risultato della ricerca: Articlepeer review

65 Citazioni (Scopus)

Abstract

Our objective was to investigate incidence of amyotrophic lateral sclerosis (ALS) in Sicily, southern Italy, by means of apopulation based study. We included people with ALS resident in fi ve Sicilian provinces, whose onset occurred in thetwo-year period 2005 2006 (population at 31 December 2006: 3,481,096 inhabitants). A multisource case-fi nding procedurewas adopted and patients were classifi ed as affected by ALS according to revised El Escorial criteria. During thetwo-year surveillance period, 97 patients meeting eligibility criteria included 57 males (58.8%) and 40 females (41.2%).Crude annual incidence rate was 1.4/100,000 person years (95% CI 1.33 1.47). The incidence rate was higher in males(1.71/100,000; CI 1.61 1.81) than in females (1.11/100,000; CI 1.01 1.21). Standardized incidence rate for the totalpopulation in the 45 74-years-old age group was 3.22 (CI 3.11 3.33). Prevalence rate was 6.0/100,000 (CI 5.97 6.03),higher in males (7.1/100,000; CI 7.02 7.18) than females (4.9/100,000; CI 4.86 4.94). In conclusion, ALS rates observedin the present study are higher in males than females, with a peak of incidence at 70 years of age in both genders. Thesefi ndings are consistent with those of other population based European studies
Lingua originaleEnglish
pagine (da-a)284-287
Numero di pagine4
RivistaAmyotrophic Lateral Sclerosis
Volume13
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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