Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project

Andrea Cortegiani, Santi Maurizio Raineri, Joost Wauters, Guillaume Voiriot, Katrien Lagrou, Ignacio Martin-Loeches, Anna M. Azzini, Philippe Montravers, Cristiano Alicino, Jean-François Timsit, Antonio Vena, Alessio Mesini, Daniele R. Giacobbe, Cecilia Trucchi, Alessia Carnelutti, Silvia Corcione, Maria Merelli, George Dimopoulos, Maria-Panagiota Almyroudi, Mario TumbarelloRoberto Luzzati, Jeroen Schouten, Vaclava Adamkova, Enora Atchade, Valentino Tisa, Simon Dubler, Matteo Bassetti, Polychronis Tasioudis, Stefano Ianniruberto, Riina Rautemaa-Richardson, Matteo Bassetti, Clement Le Bihan, Ana J. Marques, Charlotte H. S. B. Van Den Berg, Riina Rautemaa-Richardson, Novella Carannante, Pierluigi Brugnaro, Maddalena Peghin, Filippo Ansaldi, Massimo Girardis, José L. García-Garmendia, Manu L. N. G. Malbrain, Oliver A. Cornely, Benoit Veber, Mario Venditti, Bart Jan Kullberg, Herbert Spapen, Massimo Antonelli, José-Artur Paiva, Charlotte H. S. B. Van Den Berg

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.
Lingua originaleEnglish
Numero di pagine0
RivistaCritical Care
Volume23
Stato di pubblicazionePublished - 2019

Fingerprint

Invasive Candidiasis
Intensive Care Units
Incidence
Odds Ratio
Candidemia
Episode of Care
Mortality
Candidiasis
Liver Failure
Infection Control
Septic Shock
Multicenter Studies
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cita questo

Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project. / Cortegiani, Andrea; Raineri, Santi Maurizio; Wauters, Joost; Voiriot, Guillaume; Lagrou, Katrien; Martin-Loeches, Ignacio; Azzini, Anna M.; Montravers, Philippe; Alicino, Cristiano; Timsit, Jean-François; Vena, Antonio; Mesini, Alessio; Giacobbe, Daniele R.; Trucchi, Cecilia; Carnelutti, Alessia; Corcione, Silvia; Merelli, Maria; Dimopoulos, George; Almyroudi, Maria-Panagiota; Tumbarello, Mario; Luzzati, Roberto; Schouten, Jeroen; Adamkova, Vaclava; Atchade, Enora; Tisa, Valentino; Dubler, Simon; Bassetti, Matteo; Tasioudis, Polychronis; Ianniruberto, Stefano; Rautemaa-Richardson, Riina; Bassetti, Matteo; Le Bihan, Clement; Marques, Ana J.; Van Den Berg, Charlotte H. S. B.; Rautemaa-Richardson, Riina; Carannante, Novella; Brugnaro, Pierluigi; Peghin, Maddalena; Ansaldi, Filippo; Girardis, Massimo; García-Garmendia, José L.; Malbrain, Manu L. N. G.; Cornely, Oliver A.; Veber, Benoit; Venditti, Mario; Kullberg, Bart Jan; Spapen, Herbert; Antonelli, Massimo; Paiva, José-Artur; Van Den Berg, Charlotte H. S. B.

In: Critical Care, Vol. 23, 2019.

Risultato della ricerca: Article

Cortegiani, A, Raineri, SM, Wauters, J, Voiriot, G, Lagrou, K, Martin-Loeches, I, Azzini, AM, Montravers, P, Alicino, C, Timsit, J-F, Vena, A, Mesini, A, Giacobbe, DR, Trucchi, C, Carnelutti, A, Corcione, S, Merelli, M, Dimopoulos, G, Almyroudi, M-P, Tumbarello, M, Luzzati, R, Schouten, J, Adamkova, V, Atchade, E, Tisa, V, Dubler, S, Bassetti, M, Tasioudis, P, Ianniruberto, S, Rautemaa-Richardson, R, Bassetti, M, Le Bihan, C, Marques, AJ, Van Den Berg, CHSB, Rautemaa-Richardson, R, Carannante, N, Brugnaro, P, Peghin, M, Ansaldi, F, Girardis, M, García-Garmendia, JL, Malbrain, MLNG, Cornely, OA, Veber, B, Venditti, M, Kullberg, BJ, Spapen, H, Antonelli, M, Paiva, J-A & Van Den Berg, CHSB 2019, 'Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project', Critical Care, vol. 23.
Cortegiani, Andrea ; Raineri, Santi Maurizio ; Wauters, Joost ; Voiriot, Guillaume ; Lagrou, Katrien ; Martin-Loeches, Ignacio ; Azzini, Anna M. ; Montravers, Philippe ; Alicino, Cristiano ; Timsit, Jean-François ; Vena, Antonio ; Mesini, Alessio ; Giacobbe, Daniele R. ; Trucchi, Cecilia ; Carnelutti, Alessia ; Corcione, Silvia ; Merelli, Maria ; Dimopoulos, George ; Almyroudi, Maria-Panagiota ; Tumbarello, Mario ; Luzzati, Roberto ; Schouten, Jeroen ; Adamkova, Vaclava ; Atchade, Enora ; Tisa, Valentino ; Dubler, Simon ; Bassetti, Matteo ; Tasioudis, Polychronis ; Ianniruberto, Stefano ; Rautemaa-Richardson, Riina ; Bassetti, Matteo ; Le Bihan, Clement ; Marques, Ana J. ; Van Den Berg, Charlotte H. S. B. ; Rautemaa-Richardson, Riina ; Carannante, Novella ; Brugnaro, Pierluigi ; Peghin, Maddalena ; Ansaldi, Filippo ; Girardis, Massimo ; García-Garmendia, José L. ; Malbrain, Manu L. N. G. ; Cornely, Oliver A. ; Veber, Benoit ; Venditti, Mario ; Kullberg, Bart Jan ; Spapen, Herbert ; Antonelli, Massimo ; Paiva, José-Artur ; Van Den Berg, Charlotte H. S. B. / Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project. In: Critical Care. 2019 ; Vol. 23.
@article{c884ba318b6f4876a122b05ffa1cc820,
title = "Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project",
abstract = "Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42{\%}. Age (odds ratio [OR] 1.04 per year, 95{\%} CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95{\%} 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95{\%} CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95{\%} CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.",
author = "Andrea Cortegiani and Raineri, {Santi Maurizio} and Joost Wauters and Guillaume Voiriot and Katrien Lagrou and Ignacio Martin-Loeches and Azzini, {Anna M.} and Philippe Montravers and Cristiano Alicino and Jean-Fran{\cc}ois Timsit and Antonio Vena and Alessio Mesini and Giacobbe, {Daniele R.} and Cecilia Trucchi and Alessia Carnelutti and Silvia Corcione and Maria Merelli and George Dimopoulos and Maria-Panagiota Almyroudi and Mario Tumbarello and Roberto Luzzati and Jeroen Schouten and Vaclava Adamkova and Enora Atchade and Valentino Tisa and Simon Dubler and Matteo Bassetti and Polychronis Tasioudis and Stefano Ianniruberto and Riina Rautemaa-Richardson and Matteo Bassetti and {Le Bihan}, Clement and Marques, {Ana J.} and {Van Den Berg}, {Charlotte H. S. B.} and Riina Rautemaa-Richardson and Novella Carannante and Pierluigi Brugnaro and Maddalena Peghin and Filippo Ansaldi and Massimo Girardis and Garc{\'i}a-Garmendia, {Jos{\'e} L.} and Malbrain, {Manu L. N. G.} and Cornely, {Oliver A.} and Benoit Veber and Mario Venditti and Kullberg, {Bart Jan} and Herbert Spapen and Massimo Antonelli and Jos{\'e}-Artur Paiva and {Van Den Berg}, {Charlotte H. S. B.}",
year = "2019",
language = "English",
volume = "23",
journal = "Critical Care",
issn = "1364-8535",
publisher = "Springer Science + Business Media",

}

TY - JOUR

T1 - Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project

AU - Cortegiani, Andrea

AU - Raineri, Santi Maurizio

AU - Wauters, Joost

AU - Voiriot, Guillaume

AU - Lagrou, Katrien

AU - Martin-Loeches, Ignacio

AU - Azzini, Anna M.

AU - Montravers, Philippe

AU - Alicino, Cristiano

AU - Timsit, Jean-François

AU - Vena, Antonio

AU - Mesini, Alessio

AU - Giacobbe, Daniele R.

AU - Trucchi, Cecilia

AU - Carnelutti, Alessia

AU - Corcione, Silvia

AU - Merelli, Maria

AU - Dimopoulos, George

AU - Almyroudi, Maria-Panagiota

AU - Tumbarello, Mario

AU - Luzzati, Roberto

AU - Schouten, Jeroen

AU - Adamkova, Vaclava

AU - Atchade, Enora

AU - Tisa, Valentino

AU - Dubler, Simon

AU - Bassetti, Matteo

AU - Tasioudis, Polychronis

AU - Ianniruberto, Stefano

AU - Rautemaa-Richardson, Riina

AU - Bassetti, Matteo

AU - Le Bihan, Clement

AU - Marques, Ana J.

AU - Van Den Berg, Charlotte H. S. B.

AU - Rautemaa-Richardson, Riina

AU - Carannante, Novella

AU - Brugnaro, Pierluigi

AU - Peghin, Maddalena

AU - Ansaldi, Filippo

AU - Girardis, Massimo

AU - García-Garmendia, José L.

AU - Malbrain, Manu L. N. G.

AU - Cornely, Oliver A.

AU - Veber, Benoit

AU - Venditti, Mario

AU - Kullberg, Bart Jan

AU - Spapen, Herbert

AU - Antonelli, Massimo

AU - Paiva, José-Artur

AU - Van Den Berg, Charlotte H. S. B.

PY - 2019

Y1 - 2019

N2 - Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

AB - Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

UR - http://hdl.handle.net/10447/360514

M3 - Article

VL - 23

JO - Critical Care

JF - Critical Care

SN - 1364-8535

ER -