In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters

Giuseppe Montalto, Manfredi Rizzo, Demidmaa Tuvdendorj, Nicola Abate, Lawrence C. Sowers, Jean-Marc Schwarz, Elizabeth J. Murphy, Viviana Ruiz-Barros, Manfredi Rizzo, Alejandro O. Munoz, Manisha Chandalia

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

Backgrounds and aims: Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans. Methods: The fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after 2H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured. Results: Linear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p < 0.001), I-HDL (r = -0.765,p < 0.001) and S-HDL (r = -0.629, p = 0.009). When analyses were performed by gender, the associations remained significant in women (HDL-C: r = 0.822,p = 0.023; L-HDL: r = 0.892,p = 0.007; I-HDL: r = -0.927,p = 0.003) but not men. Conclusions: Our study demonstrated an in vivo association between subcutaneous abdominal adipose tissue lipid dynamics and HDL parameters in humans, but this was true for women not men. Positive association with L-HDL and negative with I-HDL suggest that subcutaneous abdominal adipose tissue lipid dynamics may play an important role in production of mature functional HDL particles. Further studies evaluating the mechanism responsible for these associations and the observed gender differences are important and warranted to identify potential novel targets of intervention to increase the production of atheroprotective subclasses of HDL-Cs and thus decreasing the risks of development of atherosclerotic conditions.
Lingua originaleEnglish
pagine (da-a)147-152
Numero di pagine6
RivistaAtherosclerosis
Volume251
Stato di pubblicazionePublished - 2016

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Abdominal Subcutaneous Fat
Subcutaneous Fat
Triglycerides
Lipids
Abdominal Fat
Particle Size
Type 2 Diabetes Mellitus
Volunteers
Linear Models
Fasting
Cardiovascular Diseases
Regression Analysis
Glucose

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cita questo

Montalto, G., Rizzo, M., Tuvdendorj, D., Abate, N., Sowers, L. C., Schwarz, J-M., ... Chandalia, M. (2016). In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters. Atherosclerosis, 251, 147-152.

In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters. / Montalto, Giuseppe; Rizzo, Manfredi; Tuvdendorj, Demidmaa; Abate, Nicola; Sowers, Lawrence C.; Schwarz, Jean-Marc; Murphy, Elizabeth J.; Ruiz-Barros, Viviana; Rizzo, Manfredi; Munoz, Alejandro O.; Chandalia, Manisha.

In: Atherosclerosis, Vol. 251, 2016, pag. 147-152.

Risultato della ricerca: Article

Montalto, G, Rizzo, M, Tuvdendorj, D, Abate, N, Sowers, LC, Schwarz, J-M, Murphy, EJ, Ruiz-Barros, V, Rizzo, M, Munoz, AO & Chandalia, M 2016, 'In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters', Atherosclerosis, vol. 251, pagg. 147-152.
Montalto, Giuseppe ; Rizzo, Manfredi ; Tuvdendorj, Demidmaa ; Abate, Nicola ; Sowers, Lawrence C. ; Schwarz, Jean-Marc ; Murphy, Elizabeth J. ; Ruiz-Barros, Viviana ; Rizzo, Manfredi ; Munoz, Alejandro O. ; Chandalia, Manisha. / In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters. In: Atherosclerosis. 2016 ; Vol. 251. pagg. 147-152.
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title = "In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters",
abstract = "Backgrounds and aims: Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans. Methods: The fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after 2H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured. Results: Linear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p < 0.001), I-HDL (r = -0.765,p < 0.001) and S-HDL (r = -0.629, p = 0.009). When analyses were performed by gender, the associations remained significant in women (HDL-C: r = 0.822,p = 0.023; L-HDL: r = 0.892,p = 0.007; I-HDL: r = -0.927,p = 0.003) but not men. Conclusions: Our study demonstrated an in vivo association between subcutaneous abdominal adipose tissue lipid dynamics and HDL parameters in humans, but this was true for women not men. Positive association with L-HDL and negative with I-HDL suggest that subcutaneous abdominal adipose tissue lipid dynamics may play an important role in production of mature functional HDL particles. Further studies evaluating the mechanism responsible for these associations and the observed gender differences are important and warranted to identify potential novel targets of intervention to increase the production of atheroprotective subclasses of HDL-Cs and thus decreasing the risks of development of atherosclerotic conditions.",
keywords = "Adipocyte; Atheroprotective; Gender-related; HDL-C metabolism; Mass spectrometry; Stable isotope tracer kinetics; Triglycerides; Cardiology and Cardiovascular Medicine",
author = "Giuseppe Montalto and Manfredi Rizzo and Demidmaa Tuvdendorj and Nicola Abate and Sowers, {Lawrence C.} and Jean-Marc Schwarz and Murphy, {Elizabeth J.} and Viviana Ruiz-Barros and Manfredi Rizzo and Munoz, {Alejandro O.} and Manisha Chandalia",
year = "2016",
language = "English",
volume = "251",
pages = "147--152",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters

AU - Montalto, Giuseppe

AU - Rizzo, Manfredi

AU - Tuvdendorj, Demidmaa

AU - Abate, Nicola

AU - Sowers, Lawrence C.

AU - Schwarz, Jean-Marc

AU - Murphy, Elizabeth J.

AU - Ruiz-Barros, Viviana

AU - Rizzo, Manfredi

AU - Munoz, Alejandro O.

AU - Chandalia, Manisha

PY - 2016

Y1 - 2016

N2 - Backgrounds and aims: Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans. Methods: The fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after 2H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured. Results: Linear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p < 0.001), I-HDL (r = -0.765,p < 0.001) and S-HDL (r = -0.629, p = 0.009). When analyses were performed by gender, the associations remained significant in women (HDL-C: r = 0.822,p = 0.023; L-HDL: r = 0.892,p = 0.007; I-HDL: r = -0.927,p = 0.003) but not men. Conclusions: Our study demonstrated an in vivo association between subcutaneous abdominal adipose tissue lipid dynamics and HDL parameters in humans, but this was true for women not men. Positive association with L-HDL and negative with I-HDL suggest that subcutaneous abdominal adipose tissue lipid dynamics may play an important role in production of mature functional HDL particles. Further studies evaluating the mechanism responsible for these associations and the observed gender differences are important and warranted to identify potential novel targets of intervention to increase the production of atheroprotective subclasses of HDL-Cs and thus decreasing the risks of development of atherosclerotic conditions.

AB - Backgrounds and aims: Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans. Methods: The fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after 2H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured. Results: Linear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p < 0.001), I-HDL (r = -0.765,p < 0.001) and S-HDL (r = -0.629, p = 0.009). When analyses were performed by gender, the associations remained significant in women (HDL-C: r = 0.822,p = 0.023; L-HDL: r = 0.892,p = 0.007; I-HDL: r = -0.927,p = 0.003) but not men. Conclusions: Our study demonstrated an in vivo association between subcutaneous abdominal adipose tissue lipid dynamics and HDL parameters in humans, but this was true for women not men. Positive association with L-HDL and negative with I-HDL suggest that subcutaneous abdominal adipose tissue lipid dynamics may play an important role in production of mature functional HDL particles. Further studies evaluating the mechanism responsible for these associations and the observed gender differences are important and warranted to identify potential novel targets of intervention to increase the production of atheroprotective subclasses of HDL-Cs and thus decreasing the risks of development of atherosclerotic conditions.

KW - Adipocyte; Atheroprotective; Gender-related; HDL-C metabolism; Mass spectrometry; Stable isotope tracer kinetics; Triglycerides; Cardiology and Cardiovascular Medicine

UR - http://hdl.handle.net/10447/197602

UR - http://www.elsevier.com/locate/atherosclerosis

M3 - Article

VL - 251

SP - 147

EP - 152

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -