1 Citazione (Scopus)

Abstract

There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive,repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-yearoldpatient with desquamative gingivitis. However, a negative Nikolsky’s sign did not seem to indicate a diagnosisof mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisionalbiopsy. As an imaging method, the use of optical coherence tomography (OCT) has enabled the obtaining oftomographic (cross-sectional) scans of tissue. Such images are acquired prior to and after verifying Nikolsky’ssign, thereby enabling the clinician to identify the presence (or not) of subepithelial bullae. Thereafter, an assessmentof changes in the subepithelium (the split) can be performed, even in the absence of a suitable clinical picture,such as, for example, a negative Nikolsky’s sign. Histological analysis and the use of indirectimmunofluorescence have facilitated a diagnosis of mucous membrane pemphigoid, an autoimmune pathology,which can be confirmed with the appearance of subepithelial bullae. OCT was found to be a valid, non-invasive,auxiliary diagnostic device, capable of revealing in vivo and real-time bullae, which were hitherto clinically undetectable.
Lingua originaleEnglish
pagine (da-a)603-605
Numero di pagine3
RivistaJournal of Dermatology
Volume45
Stato di pubblicazionePublished - 2018

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Bullous Pemphigoid
Optical Coherence Tomography
Blister
Mucous Membrane
Pathology
Gingivitis
Mouth Mucosa
Mouth
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Dermatology

Cita questo

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title = "In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign",
abstract = "There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive,repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-yearoldpatient with desquamative gingivitis. However, a negative Nikolsky’s sign did not seem to indicate a diagnosisof mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisionalbiopsy. As an imaging method, the use of optical coherence tomography (OCT) has enabled the obtaining oftomographic (cross-sectional) scans of tissue. Such images are acquired prior to and after verifying Nikolsky’ssign, thereby enabling the clinician to identify the presence (or not) of subepithelial bullae. Thereafter, an assessmentof changes in the subepithelium (the split) can be performed, even in the absence of a suitable clinical picture,such as, for example, a negative Nikolsky’s sign. Histological analysis and the use of indirectimmunofluorescence have facilitated a diagnosis of mucous membrane pemphigoid, an autoimmune pathology,which can be confirmed with the appearance of subepithelial bullae. OCT was found to be a valid, non-invasive,auxiliary diagnostic device, capable of revealing in vivo and real-time bullae, which were hitherto clinically undetectable.",
author = "Giuseppina Campisi and Giorgia Capocasale and Vito Rodolico and {Di Fede}, Olga and Vera Panzarella",
year = "2018",
language = "English",
volume = "45",
pages = "603--605",
journal = "Journal of Dermatology",
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T1 - In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign

AU - Campisi, Giuseppina

AU - Capocasale, Giorgia

AU - Rodolico, Vito

AU - Di Fede, Olga

AU - Panzarella, Vera

PY - 2018

Y1 - 2018

N2 - There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive,repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-yearoldpatient with desquamative gingivitis. However, a negative Nikolsky’s sign did not seem to indicate a diagnosisof mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisionalbiopsy. As an imaging method, the use of optical coherence tomography (OCT) has enabled the obtaining oftomographic (cross-sectional) scans of tissue. Such images are acquired prior to and after verifying Nikolsky’ssign, thereby enabling the clinician to identify the presence (or not) of subepithelial bullae. Thereafter, an assessmentof changes in the subepithelium (the split) can be performed, even in the absence of a suitable clinical picture,such as, for example, a negative Nikolsky’s sign. Histological analysis and the use of indirectimmunofluorescence have facilitated a diagnosis of mucous membrane pemphigoid, an autoimmune pathology,which can be confirmed with the appearance of subepithelial bullae. OCT was found to be a valid, non-invasive,auxiliary diagnostic device, capable of revealing in vivo and real-time bullae, which were hitherto clinically undetectable.

AB - There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive,repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-yearoldpatient with desquamative gingivitis. However, a negative Nikolsky’s sign did not seem to indicate a diagnosisof mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisionalbiopsy. As an imaging method, the use of optical coherence tomography (OCT) has enabled the obtaining oftomographic (cross-sectional) scans of tissue. Such images are acquired prior to and after verifying Nikolsky’ssign, thereby enabling the clinician to identify the presence (or not) of subepithelial bullae. Thereafter, an assessmentof changes in the subepithelium (the split) can be performed, even in the absence of a suitable clinical picture,such as, for example, a negative Nikolsky’s sign. Histological analysis and the use of indirectimmunofluorescence have facilitated a diagnosis of mucous membrane pemphigoid, an autoimmune pathology,which can be confirmed with the appearance of subepithelial bullae. OCT was found to be a valid, non-invasive,auxiliary diagnostic device, capable of revealing in vivo and real-time bullae, which were hitherto clinically undetectable.

UR - http://hdl.handle.net/10447/294427

M3 - Article

VL - 45

SP - 603

EP - 605

JO - Journal of Dermatology

JF - Journal of Dermatology

SN - 0385-2407

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