In Vitro Antitumor Effects of the Cold-Water Extracts of Mediterranean Species of Genus Pleurotus (Higher Basidiomycetes) on Human Colon Cancer Cells

Risultato della ricerca: Articlepeer review

13 Citazioni (Scopus)

Abstract

The aim of the present study was to evaluate whether the cold-water extract of Pleurotus eryngii var. ferulae (CWE-Pef) and Pleurotus nebrodensis (CWE-Pn), two of the most prized wild and cultivated edible mushrooms can affect the tumour phenotype of human colon cancer HCT116 cells. Our results showed that treatment with CWE-Pef and CWE-Pn resulted in a significant inhibition of the viability of HCT116 cells and promoted apoptosis as also demonstrated by the increase of bax/bcl-2 mRNA ratio. Moreover, we observed that both extracts were able to inhibit cell migration and to affect homotypic and heterotypic cell-cell adhesion. It was also found that treatment with CWE-Pef and CWE-Pn negatively modulated the protein tyrosine phosphorylation as well as the phosphorylation levels of ERK1/2. In conclusion, the in vitro antitumor effects of CWE-Pef and CWE-Pn indicate that they can be considered as possible sources for new alternative therapeutic agents for cancer treatment.
Lingua originaleEnglish
pagine (da-a)49-63
Numero di pagine15
RivistaInternational Journal of Medicinal Mushrooms
Volume16
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery

Fingerprint Entra nei temi di ricerca di 'In Vitro Antitumor Effects of the Cold-Water Extracts of Mediterranean Species of Genus Pleurotus (Higher Basidiomycetes) on Human Colon Cancer Cells'. Insieme formano una fingerprint unica.

Cita questo