In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate

Andrea Santulli, Concetta Maria Messina, Rita Turnaturi, Ludovica Maria Santagati, Andrea Santulli, Lorella Pasquinucci, Lucia Montenegro, Carmela Parenti, Rosaria Arena, Simona Manuguerra

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1 Citazioni (Scopus)

Abstract

Idebenone (IDE) is a strong antioxidant that has been proposed for the treatment of skin disorders, including skin ageing. Unfavorable physico-chemical properties make IDE a poor skin permeant where effectiveness could be improved by its loading into suitable delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). In this work, we designed novel IDE-loaded NLC containing tocopheryl acetate (VitE) as a liquid component to obtain a synergic effect between IDE and VitE. The resulting NLC showed small particle sizes (24-42 nm), low polydispersity indices (<0.300), good stability, and were assessed for their in vitro antioxidant activity and in vivo topical effects. IDE-loaded SLN and NLC showed a high antioxidant activity in in vitro assays (DPPH and reducing power method) and provided a similar and significant protection from oxidative stress of fibroblast cells, HS-68, exposed to UV light. After a two-week topical treatment of human volunteers with gels containing IDE-loaded SLN or NLC, a similar increase in skin hydration was observed, while IDE NLC reduced skin pigmentation to a greater extent than IDE SLN. These results suggest that co-loading IDE and VitE into NLC could be a promising strategy to obtain topical formulations with improved photo-protection.
Lingua originaleEnglish
pagine (da-a)00-00
Numero di pagine1
RivistaAPPLIED SCIENCES
Volume9
Stato di pubblicazionePublished - 2019

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

Cita questo

Santulli, A., Messina, C. M., Turnaturi, R., Santagati, L. M., Santulli, A., Pasquinucci, L., Montenegro, L., Parenti, C., Arena, R., & Manuguerra, S. (2019). In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate. APPLIED SCIENCES, 9, 00-00.