In vitro antileishmanial activity of trans-stilbene and terphenyl compounds

Antonio Cascio, Claudia Colomba, Elisa Giacomini, Fabrizio Vitale, Federica Bruno, Germano Castelli, Laura Guidotti, Marinella Roberti, Fabrizio Vitale

Risultato della ricerca: Articlepeer review

8 Citazioni (Scopus)

Abstract

Leishmaniasis are globally widespread parasitic diseases which often leads to death if left untreated. Currently available drugs present different drawbacks, so there is an urgent need to develop new, safe and cost-effective drugs against leishmaniasis. In this study we tested a small library of trans-stilbene and terphenyl derivatives against promastigote, amastigotes and intramacrophage amastigote forms of Leishmania infantum. Two compounds of the series, the trans-stilbene 3 and the terphenyl 11, presented the best activity and safety profiles. Terphenyl 11 showed a leshmanicidal activity higher than pentostam and the ability to induce apoptosis selectively in Leishmania infantum while saving macrophages and primary epithelial cells. Our data indicate that terphenyl compounds, as well as stilbenes, are endowed with leishmanicidal activity, showing potential for further studies in the context of leishmanial therapy.
Lingua originaleEnglish
pagine (da-a)1-9
Numero di pagine9
RivistaExperimental Parasitology
Volume166
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology
  • Infectious Diseases

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