In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative

Maria Eleonora Milici, Giuseppe Pizzo, Giovanni Giammanco, Chiara B. Vicentini, Francesco Barchiesi, Daniele Giannini, Anna M. Schimizzi, Daniela Arzeni, Maurizio Manfrini, Giorgio Scalise

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)

Abstract

We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolates tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentrations ≥10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C. neoformans.
Lingua originaleEnglish
pagine (da-a)167-170
Numero di pagine4
RivistaJournal of Antimicrobial Chemotherapy
Volume51
Stato di pubblicazionePublished - 2003

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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