In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative

Maria Eleonora Milici; Giuseppe Pizzo; Giovanni Giammanco; Chiara B. Vicentini; Francesco Barchiesi; Daniele Giannini; Anna M. Schimizzi; Daniela Arzeni; Maurizio Manfrini; Giorgio Scalise

In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative

Maria Eleonora Milici, Giuseppe Pizzo, Giovanni Giammanco, Chiara B. Vicentini, Francesco Barchiesi, Daniele Giannini, Anna M. Schimizzi, Daniela Arzeni, Maurizio Manfrini, Giorgio Scalise

Discipline Chirurgiche, Oncologiche e Stomatologiche
Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

4 Citazioni (Scopus)

Abstract

We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolates tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentrations ≥10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C. neoformans.

Lingua originale	English
pagine (da-a)	167-170
Numero di pagine	4
Rivista	Journal of Antimicrobial Chemotherapy
Volume	51
Stato di pubblicazione	Published - 2003

All Science Journal Classification (ASJC) codes

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In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative. / Milici, Maria Eleonora ; Pizzo, Giuseppe ; Giammanco, Giovanni; Vicentini, Chiara B.; Barchiesi, Francesco; Giannini, Daniele; Schimizzi, Anna M.; Arzeni, Daniela; Manfrini, Maurizio; Scalise, Giorgio.

In: Journal of Antimicrobial Chemotherapy, Vol. 51, 2003, pag. 167-170.

Risultato della ricerca: Article › peer review

Milici, Maria Eleonora ; Pizzo, Giuseppe ; Giammanco, Giovanni ; Vicentini, Chiara B. ; Barchiesi, Francesco ; Giannini, Daniele ; Schimizzi, Anna M. ; Arzeni, Daniela ; Manfrini, Maurizio ; Scalise, Giorgio. / In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative. In: Journal of Antimicrobial Chemotherapy. 2003 ; Vol. 51. pagg. 167-170.

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abstract = "We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolates tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentrations ≥10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C. neoformans.",

author = "Milici, {Maria Eleonora} and Giuseppe Pizzo and Giovanni Giammanco and Vicentini, {Chiara B.} and Francesco Barchiesi and Daniele Giannini and Schimizzi, {Anna M.} and Daniela Arzeni and Maurizio Manfrini and Giorgio Scalise",

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AU - Milici, Maria Eleonora

AU - Pizzo, Giuseppe

AU - Giammanco, Giovanni

AU - Vicentini, Chiara B.

AU - Barchiesi, Francesco

AU - Giannini, Daniele

AU - Schimizzi, Anna M.

AU - Arzeni, Daniela

AU - Manfrini, Maurizio

AU - Scalise, Giorgio

PY - 2003

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N2 - We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolates tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentrations ≥10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C. neoformans.

AB - We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolates tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentrations ≥10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C. neoformans.

UR - http://hdl.handle.net/10447/344199

M3 - Article

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SP - 167

EP - 170

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

ER -

In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative

Abstract

All Science Journal Classification (ASJC) codes

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