In vitro and in silico studies of polycondensed diazine systems asanti-parasitic agents

Anna Maria Almerico; Antonino Lauria; Annalisa Guarcello; Marco Tutone

In vitro and in silico studies of polycondensed diazine systems asanti-parasitic agents

Anna Maria Almerico, Antonino Lauria, Annalisa Guarcello, Marco Tutone

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

9 Citazioni (Scopus)

Abstract

Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, wesynthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. Abroad selection of these compounds were submitted to in vitro biological screening against Plasmodiumfalciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolarlevel. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about theprobable mechanism of action of the most active compounds

Lingua originale	English
pagine (da-a)	1000-1004
Numero di pagine	5
Rivista	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume	22
Stato di pubblicazione	Published - 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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abstract = "Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, wesynthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. Abroad selection of these compounds were submitted to in vitro biological screening against Plasmodiumfalciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolarlevel. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about theprobable mechanism of action of the most active compounds",

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T1 - In vitro and in silico studies of polycondensed diazine systems asanti-parasitic agents

AU - Almerico, Anna Maria

AU - Lauria, Antonino

AU - Guarcello, Annalisa

AU - Tutone, Marco

PY - 2012

Y1 - 2012

N2 - Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, wesynthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. Abroad selection of these compounds were submitted to in vitro biological screening against Plasmodiumfalciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolarlevel. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about theprobable mechanism of action of the most active compounds

AB - Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, wesynthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. Abroad selection of these compounds were submitted to in vitro biological screening against Plasmodiumfalciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolarlevel. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about theprobable mechanism of action of the most active compounds

KW - Anti-parasitic Plasmodium Leishmania Trypanosoma Diazine Induced fit docking/MM-GBSA

UR - http://hdl.handle.net/10447/64913

M3 - Article

VL - 22

SP - 1000

EP - 1004

JO - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SN - 0960-894X

ER -