TY - JOUR
T1 - In vitro activities of tetracyclines against different clones of multidrug-resistant Acinetobacter baumannii isolates from two Iranian hospitals.
AU - Mammina, Caterina
AU - Fasciana, Teresa Maria Assunta
AU - Bonura, Celestino
AU - Pajand, Omid
AU - Hojabri, Zoya
AU - Nahaei, Mohammad Reza
AU - Pirzadeh, Tahereh
AU - Hajibonabi, Farid
AU - Aghazadeh, Mohammad
AU - Hajibonabi, Farid
PY - 2014
Y1 - 2014
N2 - Acinetobacter baumannii has emerged as one of the most challenging healthcare-related pathogens and its occurrence has increased worldwide, especially in patients admitted to intensive care units. A. baumannii isolates are frequently resistant to multiple antimicrobial agents and there are recent reports of isolates resistant to virtually all clinically relevant drugs. In the present study, the in vitro activities of tigecycline, minocycline and doxycycline against 67 MDR-AB isolates recovered from 29 burn and 38 non-burn Iranian patients hospitalised in Tehran and Tabriz, respectively, were studied. Tigecycline and minocycline may be still considered effective therapeutic options for MDR-AB infections. However, ongoing monitoring of A. baumannii susceptibility to these antibiotics is required.
AB - Acinetobacter baumannii has emerged as one of the most challenging healthcare-related pathogens and its occurrence has increased worldwide, especially in patients admitted to intensive care units. A. baumannii isolates are frequently resistant to multiple antimicrobial agents and there are recent reports of isolates resistant to virtually all clinically relevant drugs. In the present study, the in vitro activities of tigecycline, minocycline and doxycycline against 67 MDR-AB isolates recovered from 29 burn and 38 non-burn Iranian patients hospitalised in Tehran and Tabriz, respectively, were studied. Tigecycline and minocycline may be still considered effective therapeutic options for MDR-AB infections. However, ongoing monitoring of A. baumannii susceptibility to these antibiotics is required.
UR - http://hdl.handle.net/10447/96805
M3 - Article
VL - 43
SP - 476
EP - 478
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
ER -