IN SITU FORMING HYDROGELS OF HYALURONIC ACID AND INULIN DERIVATIVES FOR CARTILAGE REGENERATION

Calogero Fiorica; Fabio Salvatore Palumbo; Giovanna Pitarresi; Alessandro Gulino; Gaetano Giammona; Stefano Agnello; Mauro Di Stefano; Alessandro Gulino; Giovanna Pitarresi; Gaetano Giammona

IN SITU FORMING HYDROGELS OF HYALURONIC ACID AND INULIN DERIVATIVES FOR CARTILAGE REGENERATION

Calogero Fiorica, Fabio Salvatore Palumbo, Giovanna Pitarresi, Alessandro Gulino, Gaetano Giammona, Stefano Agnello, Mauro Di Stefano, Alessandro Gulino, Giovanna Pitarresi, Gaetano Giammona

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche
Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

48 Citazioni (Scopus)

Abstract

An in situ forming hydrogel obtained by crosslinking of amino functionalized hyaluronic acid derivativeswith divinylsulfone functionalized inulin (INU-DV) has been here designed and characterized. In par-ticular two hyaluronic acid derivatives bearing respectively a pendant ethylenediamino (EDA) portion(HA-EDA) and both EDA and octadecyl pendant groups (HA-EDA-C18) were crosslinked through an azo-Michael reaction with INU-DV. Gelation time and consumption of DV portions have been evaluated onhydrogel obtained using HA-EDA and HA-EDA-C18derivatives with a concentration of 3% w/v and a ratio80/20 w/w respect to the crosslinker INU-DV. The presence of pendant C18chains improves mechanicalperformances of hydrogels and decreases the susceptibility to hyaluronidase hydrolysis. Bovine chon-drocytes, encapsulated during crosslinking, sufficiently survive and efficiently proliferate until 28 daysof analysis.

Lingua originale	English
pagine (da-a)	408-416
Numero di pagine	9
Rivista	Carbohydrate Polymers
Volume	122
Stato di pubblicazione	Published - 2015

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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IN SITU FORMING HYDROGELS OF HYALURONIC ACID AND INULIN DERIVATIVES FOR CARTILAGE REGENERATION. / Fiorica, Calogero ; Palumbo, Fabio Salvatore ; Pitarresi, Giovanna ; Gulino, Alessandro ; Giammona, Gaetano ; Agnello, Stefano; Di Stefano, Mauro; Gulino, Alessandro; Pitarresi, Giovanna; Giammona, Gaetano.

In: Carbohydrate Polymers, Vol. 122, 2015, pag. 408-416.

Risultato della ricerca: Article › peer review

Fiorica, Calogero ; Palumbo, Fabio Salvatore ; Pitarresi, Giovanna ; Gulino, Alessandro ; Giammona, Gaetano ; Agnello, Stefano ; Di Stefano, Mauro ; Gulino, Alessandro ; Pitarresi, Giovanna ; Giammona, Gaetano. / IN SITU FORMING HYDROGELS OF HYALURONIC ACID AND INULIN DERIVATIVES FOR CARTILAGE REGENERATION. In: Carbohydrate Polymers. 2015 ; Vol. 122. pagg. 408-416.

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title = "IN SITU FORMING HYDROGELS OF HYALURONIC ACID AND INULIN DERIVATIVES FOR CARTILAGE REGENERATION",

abstract = "An in situ forming hydrogel obtained by crosslinking of amino functionalized hyaluronic acid derivativeswith divinylsulfone functionalized inulin (INU-DV) has been here designed and characterized. In par-ticular two hyaluronic acid derivatives bearing respectively a pendant ethylenediamino (EDA) portion(HA-EDA) and both EDA and octadecyl pendant groups (HA-EDA-C18) were crosslinked through an azo-Michael reaction with INU-DV. Gelation time and consumption of DV portions have been evaluated onhydrogel obtained using HA-EDA and HA-EDA-C18derivatives with a concentration of 3% w/v and a ratio80/20 w/w respect to the crosslinker INU-DV. The presence of pendant C18chains improves mechanicalperformances of hydrogels and decreases the susceptibility to hyaluronidase hydrolysis. Bovine chon-drocytes, encapsulated during crosslinking, sufficiently survive and efficiently proliferate until 28 daysof analysis.",

author = "Calogero Fiorica and Palumbo, {Fabio Salvatore} and Giovanna Pitarresi and Alessandro Gulino and Gaetano Giammona and Stefano Agnello and {Di Stefano}, Mauro and Alessandro Gulino and Giovanna Pitarresi and Gaetano Giammona",

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T1 - IN SITU FORMING HYDROGELS OF HYALURONIC ACID AND INULIN DERIVATIVES FOR CARTILAGE REGENERATION

AU - Fiorica, Calogero

AU - Palumbo, Fabio Salvatore

AU - Pitarresi, Giovanna

AU - Gulino, Alessandro

AU - Giammona, Gaetano

AU - Agnello, Stefano

AU - Di Stefano, Mauro

AU - Gulino, Alessandro

AU - Pitarresi, Giovanna

AU - Giammona, Gaetano

PY - 2015

Y1 - 2015

N2 - An in situ forming hydrogel obtained by crosslinking of amino functionalized hyaluronic acid derivativeswith divinylsulfone functionalized inulin (INU-DV) has been here designed and characterized. In par-ticular two hyaluronic acid derivatives bearing respectively a pendant ethylenediamino (EDA) portion(HA-EDA) and both EDA and octadecyl pendant groups (HA-EDA-C18) were crosslinked through an azo-Michael reaction with INU-DV. Gelation time and consumption of DV portions have been evaluated onhydrogel obtained using HA-EDA and HA-EDA-C18derivatives with a concentration of 3% w/v and a ratio80/20 w/w respect to the crosslinker INU-DV. The presence of pendant C18chains improves mechanicalperformances of hydrogels and decreases the susceptibility to hyaluronidase hydrolysis. Bovine chon-drocytes, encapsulated during crosslinking, sufficiently survive and efficiently proliferate until 28 daysof analysis.

AB - An in situ forming hydrogel obtained by crosslinking of amino functionalized hyaluronic acid derivativeswith divinylsulfone functionalized inulin (INU-DV) has been here designed and characterized. In par-ticular two hyaluronic acid derivatives bearing respectively a pendant ethylenediamino (EDA) portion(HA-EDA) and both EDA and octadecyl pendant groups (HA-EDA-C18) were crosslinked through an azo-Michael reaction with INU-DV. Gelation time and consumption of DV portions have been evaluated onhydrogel obtained using HA-EDA and HA-EDA-C18derivatives with a concentration of 3% w/v and a ratio80/20 w/w respect to the crosslinker INU-DV. The presence of pendant C18chains improves mechanicalperformances of hydrogels and decreases the susceptibility to hyaluronidase hydrolysis. Bovine chon-drocytes, encapsulated during crosslinking, sufficiently survive and efficiently proliferate until 28 daysof analysis.

UR - http://hdl.handle.net/10447/148506

M3 - Article

VL - 122

SP - 408

EP - 416

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

ER -