Abstract
An in situ forming hydrogel obtained by crosslinking of amino functionalized hyaluronic acid derivativeswith divinylsulfone functionalized inulin (INU-DV) has been here designed and characterized. In par-ticular two hyaluronic acid derivatives bearing respectively a pendant ethylenediamino (EDA) portion(HA-EDA) and both EDA and octadecyl pendant groups (HA-EDA-C18) were crosslinked through an azo-Michael reaction with INU-DV. Gelation time and consumption of DV portions have been evaluated onhydrogel obtained using HA-EDA and HA-EDA-C18derivatives with a concentration of 3% w/v and a ratio80/20 w/w respect to the crosslinker INU-DV. The presence of pendant C18chains improves mechanicalperformances of hydrogels and decreases the susceptibility to hyaluronidase hydrolysis. Bovine chon-drocytes, encapsulated during crosslinking, sufficiently survive and efficiently proliferate until 28 daysof analysis.
Lingua originale | English |
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pagine (da-a) | 408-416 |
Numero di pagine | 9 |
Rivista | Carbohydrate Polymers |
Volume | 122 |
Stato di pubblicazione | Published - 2015 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.1600.1605???
- ???subjectarea.asjc.2500.2507???
- ???subjectarea.asjc.2500.2505???