Abstract
One of the major problems in the fight against cancer is drug-resistance, which, at a molecular level, can be acquired through mutations able to deactivate apoptosis. In particular, proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-xl and Bcl-2, are overexpressed in many tumours. The development of new inhibitors of these proteins as potential anticancer therapeutics represents a new frontier. In this work, we carried out an in-silico screening of compounds from a free database of more than 2 million structures (ZINC database), which allowed us to identify 17 sulfonamide derivatives as new potential inhibitors; these are currently undergoing biological evaluation.
Lingua originale | English |
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pagine (da-a) | 349-355 |
Numero di pagine | 7 |
Rivista | Journal of Molecular Modeling |
Volume | 15 |
Stato di pubblicazione | Published - 2009 |
All Science Journal Classification (ASJC) codes
- ???subjectarea.asjc.1500.1503???
- ???subjectarea.asjc.1700.1706???
- ???subjectarea.asjc.1600.1606???
- ???subjectarea.asjc.1600.1605???
- ???subjectarea.asjc.1700.1703???
- ???subjectarea.asjc.1600.1604???