Improving the preclinical models for the study of chemotherapyinduced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection

Giuseppina Novo, Martino Deidda, Alessia Pepe, Ines Monte, Christian Cadeddu, Christian Cadeddu, Martino Deidda, Martino Deidda, Carlo Gabriele Tocchetti, Concetta Zito, Rosalinda Madonna, Paolo Spallarossa, Pasquale Pagliaro, Giuseppe Mercuro, Donato Mele

Risultato della ricerca: Article

31 Citazioni (Scopus)

Abstract

Although treatment for heart failure inducedby cancer therapy has improved in recent years, theprevalence of cardiomyopathy due to antineoplastic therapyremains significant worldwide. In addition to traditionalmediators of myocardial damage, such as reactiveoxygen species, new pathways and target cells should beconsidered responsible for the impairment of cardiacfunction during anticancer treatment. Accordingly, thereis a need to develop novel therapeutic strategies to protectthe heart from pharmacologic injury, and improve clinicaloutcomes in cancer patients. The development of novelprotective therapies requires testing putative therapeuticstrategies in appropriate animal models of chemotherapyinducedcardiomyopathy. This Position Paper of theWorking Group on Drug Cardiotoxicity and Cardioprotectionof the Italian Society of Cardiology aims to: (1)define the distinctive etiopatogenetic features of cardiactoxicity induced by cancer therapy in humans, whichinclude new aspects of mitochondrial function andoxidative stress, neuregulin-1 modulation through theErbB receptor family, angiogenesis inhibition, and cardiacstem cell depletion and/or dysfunction; (2) review thenew, more promising therapeutic strategies for cardioprotection,aimed to increase the survival of patients withsevere antineoplastic-induced cardiotoxicity; (3) recommendthe distinctive pathological features of cardiotoxicityinduced by cancer therapy in humans that should bepresent in animal models used to identify or to test newcardioprotective therapies.
Lingua originaleEnglish
pagine (da-a)621-631
Numero di pagine11
RivistaHeart Failure Reviews
Volume20
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Novo, G., Deidda, M., Pepe, A., Monte, I., Cadeddu, C., Cadeddu, C., Deidda, M., Deidda, M., Tocchetti, C. G., Zito, C., Madonna, R., Spallarossa, P., Pagliaro, P., Mercuro, G., & Mele, D. (2015). Improving the preclinical models for the study of chemotherapyinduced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection. Heart Failure Reviews, 20, 621-631.