Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily

Pietro Ammatuna, Giuseppina Colonna Romano, Domenico Lio, Giuseppina Candore, Calogero Caruso, Matteo Bulati, Arne N. Akbar, Graham Pawelec, Jean M. Fletcher, Alessandra Aquino

Risultato della ricerca: Articlepeer review

26 Citazioni (Scopus)

Abstract

Herpes viruses (particularly CMV and to some extent EBV) might play a role in accelerating the deterioration of immune functionswith age. Indeed, it has been demonstrated that chronic infection with CMV causes an expansion of specific CD8 T lymphocytes and thatthis is related to a shrinkage of the T cell repertoire in very elderly people, predicting mortality. We have analysed CD8 T cells in youngand old healthy Sicilians who were both CMV- and EBV-seropositive. Our data confirm expansions of T cells specific for the HLA-A2-restricted pp65 (495–503) CMV epitope up to nearly 14% of total peripheral CD8 cells in certain elderly individuals (range 0–14%). However,the mean percentage of CMV-specific cells in the elderly was not greater than the young (range 0.2–3%). The CMV-specific CD8cells in the elderly were predominantly CD45RA+, but in the young they were mostly CD45RO+. Our findings are somewhat differentfrom published reports from Northern European populations, both in terms of mean numbers and surface phenotypes. These findingsmay reflect disparate hygienic and nutritional conditions 70–90 yr ago, which were very different in Northern and Southern Europe atthat time, as well as a different genetic background.
Lingua originaleEnglish
pagine (da-a)995-1002
Numero di pagine8
RivistaExperimental Gerontology
Volume42
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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