Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily

Giuseppina Candore, Giuseppina Colonna Romano, Matteo Bulati, Domenico Lio, Pietro Ammatuna, Calogero Caruso, Arne N. Akbar, Graham Pawelec, Jean M. Fletcher, Alessandra Aquino

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Abstract

Herpes viruses (particularly CMV and to some extent EBV) might play a role in accelerating the deterioration of immune functionswith age. Indeed, it has been demonstrated that chronic infection with CMV causes an expansion of specific CD8 T lymphocytes and thatthis is related to a shrinkage of the T cell repertoire in very elderly people, predicting mortality. We have analysed CD8 T cells in youngand old healthy Sicilians who were both CMV- and EBV-seropositive. Our data confirm expansions of T cells specific for the HLA-A2-restricted pp65 (495–503) CMV epitope up to nearly 14% of total peripheral CD8 cells in certain elderly individuals (range 0–14%). However,the mean percentage of CMV-specific cells in the elderly was not greater than the young (range 0.2–3%). The CMV-specific CD8cells in the elderly were predominantly CD45RA+, but in the young they were mostly CD45RO+. Our findings are somewhat differentfrom published reports from Northern European populations, both in terms of mean numbers and surface phenotypes. These findingsmay reflect disparate hygienic and nutritional conditions 70–90 yr ago, which were very different in Northern and Southern Europe atthat time, as well as a different genetic background.
Lingua originaleEnglish
pagine (da-a)995-1002
Numero di pagine8
RivistaExperimental Gerontology
Volume42
Stato di pubblicazionePublished - 2007

Fingerprint

Sicily
T-cells
Human Herpesvirus 4
T-Lymphocytes
Population
HLA-A2 Antigen
Viruses
Deterioration
Epitopes
Phenotype
Mortality
Infection

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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title = "Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily",
abstract = "Herpes viruses (particularly CMV and to some extent EBV) might play a role in accelerating the deterioration of immune functionswith age. Indeed, it has been demonstrated that chronic infection with CMV causes an expansion of specific CD8 T lymphocytes and thatthis is related to a shrinkage of the T cell repertoire in very elderly people, predicting mortality. We have analysed CD8 T cells in youngand old healthy Sicilians who were both CMV- and EBV-seropositive. Our data confirm expansions of T cells specific for the HLA-A2-restricted pp65 (495–503) CMV epitope up to nearly 14{\%} of total peripheral CD8 cells in certain elderly individuals (range 0–14{\%}). However,the mean percentage of CMV-specific cells in the elderly was not greater than the young (range 0.2–3{\%}). The CMV-specific CD8cells in the elderly were predominantly CD45RA+, but in the young they were mostly CD45RO+. Our findings are somewhat differentfrom published reports from Northern European populations, both in terms of mean numbers and surface phenotypes. These findingsmay reflect disparate hygienic and nutritional conditions 70–90 yr ago, which were very different in Northern and Southern Europe atthat time, as well as a different genetic background.",
author = "Giuseppina Candore and {Colonna Romano}, Giuseppina and Matteo Bulati and Domenico Lio and Pietro Ammatuna and Calogero Caruso and Akbar, {Arne N.} and Graham Pawelec and Fletcher, {Jean M.} and Alessandra Aquino",
year = "2007",
language = "English",
volume = "42",
pages = "995--1002",
journal = "Experimental Gerontology",
issn = "0531-5565",
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TY - JOUR

T1 - Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily

AU - Candore, Giuseppina

AU - Colonna Romano, Giuseppina

AU - Bulati, Matteo

AU - Lio, Domenico

AU - Ammatuna, Pietro

AU - Caruso, Calogero

AU - Akbar, Arne N.

AU - Pawelec, Graham

AU - Fletcher, Jean M.

AU - Aquino, Alessandra

PY - 2007

Y1 - 2007

N2 - Herpes viruses (particularly CMV and to some extent EBV) might play a role in accelerating the deterioration of immune functionswith age. Indeed, it has been demonstrated that chronic infection with CMV causes an expansion of specific CD8 T lymphocytes and thatthis is related to a shrinkage of the T cell repertoire in very elderly people, predicting mortality. We have analysed CD8 T cells in youngand old healthy Sicilians who were both CMV- and EBV-seropositive. Our data confirm expansions of T cells specific for the HLA-A2-restricted pp65 (495–503) CMV epitope up to nearly 14% of total peripheral CD8 cells in certain elderly individuals (range 0–14%). However,the mean percentage of CMV-specific cells in the elderly was not greater than the young (range 0.2–3%). The CMV-specific CD8cells in the elderly were predominantly CD45RA+, but in the young they were mostly CD45RO+. Our findings are somewhat differentfrom published reports from Northern European populations, both in terms of mean numbers and surface phenotypes. These findingsmay reflect disparate hygienic and nutritional conditions 70–90 yr ago, which were very different in Northern and Southern Europe atthat time, as well as a different genetic background.

AB - Herpes viruses (particularly CMV and to some extent EBV) might play a role in accelerating the deterioration of immune functionswith age. Indeed, it has been demonstrated that chronic infection with CMV causes an expansion of specific CD8 T lymphocytes and thatthis is related to a shrinkage of the T cell repertoire in very elderly people, predicting mortality. We have analysed CD8 T cells in youngand old healthy Sicilians who were both CMV- and EBV-seropositive. Our data confirm expansions of T cells specific for the HLA-A2-restricted pp65 (495–503) CMV epitope up to nearly 14% of total peripheral CD8 cells in certain elderly individuals (range 0–14%). However,the mean percentage of CMV-specific cells in the elderly was not greater than the young (range 0.2–3%). The CMV-specific CD8cells in the elderly were predominantly CD45RA+, but in the young they were mostly CD45RO+. Our findings are somewhat differentfrom published reports from Northern European populations, both in terms of mean numbers and surface phenotypes. These findingsmay reflect disparate hygienic and nutritional conditions 70–90 yr ago, which were very different in Northern and Southern Europe atthat time, as well as a different genetic background.

UR - http://hdl.handle.net/10447/59402

M3 - Article

VL - 42

SP - 995

EP - 1002

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -