Impact of chronic diuretic treatment on glucosehomeostasis

Silvio Buscemi, Maria Fatima Massenti, Giovam Battista Rini, Emanuele Amodio, Giuseppe Grosso, Giuseppe Lucisano, Giuseppe Grosso, Fabio Galvano, Antonio Nicolucci, Delia Sprini

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7 Citazioni (Scopus)


BackgroundThe use of diuretics for hypertension has been associated with unfavorable changes incardiovascular risk factors, such as uric acid and glucose tolerance, though the findings in theliterature are contradictory.MethodsThis study investigated whether diuretic use is associated with markers of metabolic andcardiovascular risk, such as insulin-resistance and uric acid, in a cohort of adults withoutknown diabetes and/or atherosclerotic cardiovascular disease. Nine hundred sixty-ninerandomly selected participants answered a questionnaire on clinical history and dietaryhabits. Laboratory blood measurements were obtained in 507 participants.ResultsPreviously undiagnosed type 2 diabetes was recognized in 4.2% of participants who were ondiuretics (n = 71), and in 2% of those who were not (n = 890; P = 0.53). Pre-diabetes wasdiagnosed in 38% of patients who were on diuretics, and in 17.4% (P < 0.001) of those whowere not. Multivariate analysis showed that insulin-resistance (HOMA-IR) was associatedwith the use of diuretics (P = 0.002) independent of other well-known predisposing factors,such as diet, physical activity, body mass index, and waist circumference. The use ofdiuretics was also independently associated with fasting plasma glucose concentrations (P =0.001) and uric acid concentrations (P = 0.01).ConclusionsThe use of diuretics is associated with insulin-resistance and serum uric acid levels and maycontribute to abnormal glucose tolerance
Lingua originaleEnglish
Numero di pagine17
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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