Immunomodulation in vascularized composite allotransplantation: What is the role for adipose-derived stem cells?

Marco Pappalardo, Sara Di Lorenzo, Francesco Dieli, Antonio Russo, Anna Barbara Di Stefano, Francesco Moschella, Luigi Montesano, Francesca Toia, Serena Meraviglia, Angelo A. Leto Barone, Antonio Russo, Francesco Dieli, Anna Barbara Di Stefano, Serena Meraviglia, Angelo Alberto Leto Barone

Risultato della ricerca: Article

2 Citazioni (Scopus)

Abstract

Hand and face transplants are becoming increasingly common, recording progressively more penile, uterus, abdominal wall, and allotransplantation cases reported worldwide. Despite current protocols allow long-term survival of the allografts, the ultimate goal of donor-specific tolerance has not been achieved yet. In fact, the harmful adverse effects related to the lifelong administration of immunosuppressive agents are the main drawbacks for vascularized composite allotransplantations. Research is very active in investigating alternative methods to induce greater tolerance while minimizing toxicity. Adipose-derived stem cells (ASCs) represent promising cell therapies for immunomodulation in preclinical and clinical settings. Their clinical appeal is due to their easy harvest in large quantities through a noninvasive and well-accepted approach; they may well promote donor-specific tolerance and potentially reduce immunosuppression. Several experimental studies exist, but lacking review articles reporting current evidence. This work proposes a literature review on the immunomodulatory role of ASCs in vascularized composite allotransplantations. In vitro and in vivo evidence will be summarized. The role that cell passaging and upstream progenitors - the so-called spheroid ASCs - may play in modulating the immune response will also be discussed. Finally, this article will summarize current knowledge on biodistribution, migration, and homing of injected stem cells. This review may well provide useful information for preclinical and clinical studies, aiming at a breakthrough for donor-specific tolerance.
Lingua originaleEnglish
pagine (da-a)245-251
Numero di pagine7
RivistaAnnals of Plastic Surgery
Volume82
Stato di pubblicazionePublished - 2019

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Vascularized Composite Allotransplantation
Immunomodulation
Stem Cells
Facial Transplantation
Abdominal Wall
Immunosuppressive Agents
Cell- and Tissue-Based Therapy
Immunosuppression
Uterus
Allografts
Hand
Research

All Science Journal Classification (ASJC) codes

  • Surgery

Cita questo

@article{ac1ae695196949378f7f4f8599807147,
title = "Immunomodulation in vascularized composite allotransplantation: What is the role for adipose-derived stem cells?",
abstract = "Hand and face transplants are becoming increasingly common, recording progressively more penile, uterus, abdominal wall, and allotransplantation cases reported worldwide. Despite current protocols allow long-term survival of the allografts, the ultimate goal of donor-specific tolerance has not been achieved yet. In fact, the harmful adverse effects related to the lifelong administration of immunosuppressive agents are the main drawbacks for vascularized composite allotransplantations. Research is very active in investigating alternative methods to induce greater tolerance while minimizing toxicity. Adipose-derived stem cells (ASCs) represent promising cell therapies for immunomodulation in preclinical and clinical settings. Their clinical appeal is due to their easy harvest in large quantities through a noninvasive and well-accepted approach; they may well promote donor-specific tolerance and potentially reduce immunosuppression. Several experimental studies exist, but lacking review articles reporting current evidence. This work proposes a literature review on the immunomodulatory role of ASCs in vascularized composite allotransplantations. In vitro and in vivo evidence will be summarized. The role that cell passaging and upstream progenitors - the so-called spheroid ASCs - may play in modulating the immune response will also be discussed. Finally, this article will summarize current knowledge on biodistribution, migration, and homing of injected stem cells. This review may well provide useful information for preclinical and clinical studies, aiming at a breakthrough for donor-specific tolerance.",
author = "Marco Pappalardo and {Di Lorenzo}, Sara and Francesco Dieli and Antonio Russo and {Di Stefano}, {Anna Barbara} and Francesco Moschella and Luigi Montesano and Francesca Toia and Serena Meraviglia and {Leto Barone}, {Angelo A.} and Antonio Russo and Francesco Dieli and {Di Stefano}, {Anna Barbara} and Serena Meraviglia and {Leto Barone}, {Angelo Alberto}",
year = "2019",
language = "English",
volume = "82",
pages = "245--251",
journal = "Annals of Plastic Surgery",
issn = "0148-7043",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Immunomodulation in vascularized composite allotransplantation: What is the role for adipose-derived stem cells?

AU - Pappalardo, Marco

AU - Di Lorenzo, Sara

AU - Dieli, Francesco

AU - Russo, Antonio

AU - Di Stefano, Anna Barbara

AU - Moschella, Francesco

AU - Montesano, Luigi

AU - Toia, Francesca

AU - Meraviglia, Serena

AU - Leto Barone, Angelo A.

AU - Russo, Antonio

AU - Dieli, Francesco

AU - Di Stefano, Anna Barbara

AU - Meraviglia, Serena

AU - Leto Barone, Angelo Alberto

PY - 2019

Y1 - 2019

N2 - Hand and face transplants are becoming increasingly common, recording progressively more penile, uterus, abdominal wall, and allotransplantation cases reported worldwide. Despite current protocols allow long-term survival of the allografts, the ultimate goal of donor-specific tolerance has not been achieved yet. In fact, the harmful adverse effects related to the lifelong administration of immunosuppressive agents are the main drawbacks for vascularized composite allotransplantations. Research is very active in investigating alternative methods to induce greater tolerance while minimizing toxicity. Adipose-derived stem cells (ASCs) represent promising cell therapies for immunomodulation in preclinical and clinical settings. Their clinical appeal is due to their easy harvest in large quantities through a noninvasive and well-accepted approach; they may well promote donor-specific tolerance and potentially reduce immunosuppression. Several experimental studies exist, but lacking review articles reporting current evidence. This work proposes a literature review on the immunomodulatory role of ASCs in vascularized composite allotransplantations. In vitro and in vivo evidence will be summarized. The role that cell passaging and upstream progenitors - the so-called spheroid ASCs - may play in modulating the immune response will also be discussed. Finally, this article will summarize current knowledge on biodistribution, migration, and homing of injected stem cells. This review may well provide useful information for preclinical and clinical studies, aiming at a breakthrough for donor-specific tolerance.

AB - Hand and face transplants are becoming increasingly common, recording progressively more penile, uterus, abdominal wall, and allotransplantation cases reported worldwide. Despite current protocols allow long-term survival of the allografts, the ultimate goal of donor-specific tolerance has not been achieved yet. In fact, the harmful adverse effects related to the lifelong administration of immunosuppressive agents are the main drawbacks for vascularized composite allotransplantations. Research is very active in investigating alternative methods to induce greater tolerance while minimizing toxicity. Adipose-derived stem cells (ASCs) represent promising cell therapies for immunomodulation in preclinical and clinical settings. Their clinical appeal is due to their easy harvest in large quantities through a noninvasive and well-accepted approach; they may well promote donor-specific tolerance and potentially reduce immunosuppression. Several experimental studies exist, but lacking review articles reporting current evidence. This work proposes a literature review on the immunomodulatory role of ASCs in vascularized composite allotransplantations. In vitro and in vivo evidence will be summarized. The role that cell passaging and upstream progenitors - the so-called spheroid ASCs - may play in modulating the immune response will also be discussed. Finally, this article will summarize current knowledge on biodistribution, migration, and homing of injected stem cells. This review may well provide useful information for preclinical and clinical studies, aiming at a breakthrough for donor-specific tolerance.

UR - http://hdl.handle.net/10447/353193

M3 - Article

VL - 82

SP - 245

EP - 251

JO - Annals of Plastic Surgery

JF - Annals of Plastic Surgery

SN - 0148-7043

ER -