TY - JOUR
T1 - IMMUNOLOGICAL ASPECTS OF CROHN'S DISEASE: A REGULATORY FUNCTION OF TIM-3/GALECTIN-9 IN LYTH1.
AU - David, Sabrina
AU - Carini, Francesco
AU - Leone, Angelo
AU - Rappa, Francesca
AU - Tomasello, Giovanni
AU - Mazzola, Margherita
AU - Zerbe, Raymond
AU - Jurjus, Abdo
AU - Gagliardo, Carola Maria
PY - 2017
Y1 - 2017
N2 - Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic environmental factors. The interaction of these factors causes an imbalance of the microbiota, leading to the activation of several immunological and inflammatory mechanism. From an immunological point of view, there seems to be an involvement of the TIM-3/GALECTIN-9 pathway and of the autoregulation of lyTh1. These studies show that in patients with CD the autoregulation of lyth1 is lost due to a reduced concentration of galectin-9 and a reduced TIM-3 expression in LyTh1. This could be one of the reason for the state of perpetual activation of lyTh1, resulting in the chronic inflammation process.
AB - Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) and its etiology is multifactorial and involves a combination of genetic environmental factors. The interaction of these factors causes an imbalance of the microbiota, leading to the activation of several immunological and inflammatory mechanism. From an immunological point of view, there seems to be an involvement of the TIM-3/GALECTIN-9 pathway and of the autoregulation of lyTh1. These studies show that in patients with CD the autoregulation of lyth1 is lost due to a reduced concentration of galectin-9 and a reduced TIM-3 expression in LyTh1. This could be one of the reason for the state of perpetual activation of lyTh1, resulting in the chronic inflammation process.
UR - http://hdl.handle.net/10447/234546
M3 - Article
SN - 2279-7165
VL - 12
SP - 66
EP - 68
JO - EuroMediterranean Biomedical Journal
JF - EuroMediterranean Biomedical Journal
ER -