Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes

Vito Chiantera, Darb-Esfahani, Eliane T. Taube, Borrelli, Sylvia Mechsner, Vito Chiantera, Abrão, Kaufmann, Christhardt Köhler

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

Endometriosis is a prevalent benign disease, despite sharing several similarities with malignancies, such as the possibility of lymphatic spread. In malignancies, chemokines play a sovereign role in the process of metastasis. Metastasis-related chemokine axes have not yet been assessed in deep-infiltrating endometriosis (DIE), and this investigation was the aim of our study. The expression of these chemokines was investigated by immunohistochemistry in rectovaginal DIE lesions and in matched pelvic sentinel lymph nodes (PSLNs) of patients with endometriosis (n = 27), and their expression in the eutopic endometrium (EE) of endometriosis-free women (n = 20) was used as controls. Their staining pattern in rectovaginal DIE, in endometriotic lesions affecting the PSLN as well as in the EE of patients without endometriosis was characterized for the first time. Overall, these chemokines were highly expressed in DIE and endometriosis in PSLN. Chemokines might be involved in the spread of endometriosis and should be further investigated.
Lingua originaleEnglish
pagine (da-a)1632-1642
Numero di pagine11
RivistaReproductive Sciences
Volume22
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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    Chiantera, V., Darb-Esfahani, Taube, E. T., Borrelli, Mechsner, S., Chiantera, V., Abrão, Kaufmann, & Köhler, C. (2015). Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes. Reproductive Sciences, 22, 1632-1642.