Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 1325-1331 |
| Numero di pagine | 7 |
| Rivista | Anticancer Research |
| Volume | 23 |
| Stato di pubblicazione | Published - 2003 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis. / Anzalone, Rita; David, Sabrina; Zummo, Giovanni; Rappa, Francesca; Cappello, Francesco; Cappello, Francesco.
In: Anticancer Research, Vol. 23, 2003, pag. 1325-1331.Risultato della ricerca: Article
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TY - JOUR
T1 - Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis
AU - Anzalone, Rita
AU - David, Sabrina
AU - Zummo, Giovanni
AU - Rappa, Francesca
AU - Cappello, Francesco
AU - Cappello, Francesco
PY - 2003
Y1 - 2003
N2 - Background: The study of the expression of different biological markers in non-neoplastic, pre-neoplastic and neoplastic lesions of prostate could help to better understand their role in carcinogenesis and to find new diagnostic and prognostic tools. Materials and Methods: In the present work we evaluated, by immunohistochemistry, the presence and the expression of PCNA, p53, HSP60, HSP10 and MUC-2 in a series of nodular hyperplasia, low- and high-grade prostatic intraepithelial lesions and adenocarcinomas. Results: Our data confirmed that: 1) PCNA expression could be related to the grade of progression of cancer; and that 2) p53 mutation could be a late event in prostate carcinogenesis. Moreover, we reported that: 1) HPS60 and HPS10 were overexpressed early in prostate carcinogenesis; and that 2) MUC-2 is absent in both tumoral and non-tumoral prostatic tissue. Conclusion: We suggest the further examination, by molecular and genetic studies, of the role of HSP60 and HSP10 during carcinogenesis of the prostate as well as of other organs.
AB - Background: The study of the expression of different biological markers in non-neoplastic, pre-neoplastic and neoplastic lesions of prostate could help to better understand their role in carcinogenesis and to find new diagnostic and prognostic tools. Materials and Methods: In the present work we evaluated, by immunohistochemistry, the presence and the expression of PCNA, p53, HSP60, HSP10 and MUC-2 in a series of nodular hyperplasia, low- and high-grade prostatic intraepithelial lesions and adenocarcinomas. Results: Our data confirmed that: 1) PCNA expression could be related to the grade of progression of cancer; and that 2) p53 mutation could be a late event in prostate carcinogenesis. Moreover, we reported that: 1) HPS60 and HPS10 were overexpressed early in prostate carcinogenesis; and that 2) MUC-2 is absent in both tumoral and non-tumoral prostatic tissue. Conclusion: We suggest the further examination, by molecular and genetic studies, of the role of HSP60 and HSP10 during carcinogenesis of the prostate as well as of other organs.
KW - Cancer Research
KW - Carcinogenesis
KW - Heat-shock proteins
KW - Oncology
KW - Prostate
UR - http://hdl.handle.net/10447/191022
M3 - Article
VL - 23
SP - 1325
EP - 1331
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
ER -