Immunohistochemical detection of early myocardial infarction: a systematic review

Elvira Ventura Spagnolo, Cristina Mondello, Luigi Cardia, Cristina Mondello

Risultato della ricerca: Articlepeer review

30 Citazioni (Scopus)


The postmortem diagnosis of early myocardial infarction is a challenge for forensic pathologists because the routine histology is neither specific. Many authors have suggested the use of the immunohistochemistry to fill the gaps in the histological diagnosis of early myocardial infarction. This review aims to analyse advances of immunohistochemical detection of early cardiac damage due to ischaemia. To this purpose, we reviewed experimental studies that investigated immunohistochemical markers and their estimated timing of expression. The review was performed according to specific inclusion and exclusion criteria, and a total of 23 studies assessing the immunohistochemical markers for the diagnosis and timing of early myocardial infarction were identified. The literature review highlights that the analysed markers are complement components, others being inflammatory mediators, cardiac cell proteins, plasma proteins, stress or hypoxia-induced factors and proteins associated with heart failure. All studies demonstrate the effectiveness of the tested markers in the early detection of myocardial infarction in both animal and human samples.
Lingua originaleEnglish
pagine (da-a)411-421
Numero di pagine11
RivistaInternational Journal of Legal Medicine
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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