‘Immunogenetics of Aging’ is a component that was first included in the 14thInternational HLA and Immunogenetics Workshop (IHIWS) and developed furtherwithin the 15th Workshop. The aim of this component was to assess the impact ofhuman leukocyte antigen (HLA) genes, cytokine genes, and some innate immunitygenes such as killer-cell immunoglobulin-like receptors (KIRs) and mannose-bindinglectin 2 (MBL2) in successful aging and their contribution to the better understandingof immune dysfunction in old age. Within the 15th IHIWS new populations wereincluded in the analysis. Additional cytokine gene polymorphisms were assessedand innate immunity genes were analyzed for possible relevance in longevity. Theresults showed that longevity might be associated with anti-inflammatory cytokinegene profiles, decreased frequency of interleukin-10 (IL-10) and transforming growthfactor-B1 haplotypes associated with a low level of gene expression, and increasedfrequency of haplotypes determining a high level of expression. Extended tumornecrosis factor-A and IL-12B genotypes were also likely relevant to longevity. Dataalso showed that innate immunity genes are associated with susceptibility to infectionsin the elderly and showed that these genes might be an important genetic marker inaging. Decreased frequencies of KIR2DS5 and A1B10 haplotypes, and an increasedproportion of MBL2-deficient haplotypes were found in the group with highercytomegalovirus-specific IgG antibody levels. Together, these studies emphasize therelevance of genes regulating immune functions in maintaining human longevity andstress the importance of further clarifying their impact on successful aging.
|Numero di pagine||6|
|Stato di pubblicazione||Published - 2011|
All Science Journal Classification (ASJC) codes
- Immunology and Allergy