Immune profiling of Alzheimer patients

Calogero Caruso, Giuseppina Colonna Romano, Giuseppina Candore, Matteo Bulati, Silvio Buffa, Francesco Iemolo, Graham Pawelec, Anis Larbi, Evelyna Derhovanessian, Mariavaleria Pellicanò, David Goldeck, Graziella Rubino

Risultato della ricerca: Article

61 Citazioni (Scopus)

Abstract

Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease
Lingua originaleEnglish
pagine (da-a)52-59
Numero di pagine8
RivistaJournal of Neuroimmunology
Volume242
Stato di pubblicazionePublished - 2012

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Alzheimer Disease
Amyloid beta-Peptides
T-Lymphocytes
Amyloid Plaques
Phenotype
Brain

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Clinical Neurology
  • Neurology
  • Immunology

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Immune profiling of Alzheimer patients. / Caruso, Calogero; Colonna Romano, Giuseppina; Candore, Giuseppina; Bulati, Matteo; Buffa, Silvio; Iemolo, Francesco; Pawelec, Graham; Larbi, Anis; Derhovanessian, Evelyna; Pellicanò, Mariavaleria; Goldeck, David; Rubino, Graziella.

In: Journal of Neuroimmunology, Vol. 242, 2012, pag. 52-59.

Risultato della ricerca: Article

Caruso, C, Colonna Romano, G, Candore, G, Bulati, M, Buffa, S, Iemolo, F, Pawelec, G, Larbi, A, Derhovanessian, E, Pellicanò, M, Goldeck, D & Rubino, G 2012, 'Immune profiling of Alzheimer patients', Journal of Neuroimmunology, vol. 242, pagg. 52-59.
Caruso, Calogero ; Colonna Romano, Giuseppina ; Candore, Giuseppina ; Bulati, Matteo ; Buffa, Silvio ; Iemolo, Francesco ; Pawelec, Graham ; Larbi, Anis ; Derhovanessian, Evelyna ; Pellicanò, Mariavaleria ; Goldeck, David ; Rubino, Graziella. / Immune profiling of Alzheimer patients. In: Journal of Neuroimmunology. 2012 ; Vol. 242. pagg. 52-59.
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AU - Colonna Romano, Giuseppina

AU - Candore, Giuseppina

AU - Bulati, Matteo

AU - Buffa, Silvio

AU - Iemolo, Francesco

AU - Pawelec, Graham

AU - Larbi, Anis

AU - Derhovanessian, Evelyna

AU - Pellicanò, Mariavaleria

AU - Goldeck, David

AU - Rubino, Graziella

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AB - Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease

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