Immune profiling of Alzheimer patients

Giuseppina Colonna Romano, Matteo Bulati, Calogero Caruso, Giuseppina Candore, Evelyna Derhovanessian, Mariavaleria Pellicanò, David Goldeck, Graziella Rubino, Francesco Iemolo, Graham Pawelec, Anis Larbi, Silvio Buffa

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64 Citazioni (Scopus)

Abstract

Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease
Lingua originaleEnglish
pagine (da-a)52-59
Numero di pagine8
RivistaJournal of Neuroimmunology
Volume242
Stato di pubblicazionePublished - 2012

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cita questo

Colonna Romano, G., Bulati, M., Caruso, C., Candore, G., Derhovanessian, E., Pellicanò, M., Goldeck, D., Rubino, G., Iemolo, F., Pawelec, G., Larbi, A., & Buffa, S. (2012). Immune profiling of Alzheimer patients. Journal of Neuroimmunology, 242, 52-59.