Centenarians are rare and exceptional individuals characterized by a peculiarphenotype. They are the best example of healthy aging in humans as most of themhave escaped or substantially delayed the onset of major age-related diseases.Within this scenario, the purpose of the present work was to understand if immunestatus is associated with survival and health status in centenarians. To thisaim, 116 centenarians were concomitantly characterized for their immunological,health and functional status, and followed-up for five-year survival. On thebasis of previous knowledge we focused on a core of fundamental and basic immune parameters (number of leukocytes, monocytes, total lymphocytes, CD3(+) Tlymphocytes, CD4(+) helper T lymphocytes, CD8(+) cytotoxic T lymphocytes, CD19(+)B lymphocytes and plasma levels of IgM), and the most important findings can besummarized as follows: i. a hierarchical cluster analysis was able to defineCluster1 (88 centenarians) and Cluster2 (28 centenarians) characterized by lowand high values of all these immune parameters, respectively; ii. centenarians ofCluster2 showed a statistically longer five-year survival and more favorablevalues of other important immune (naÃ¯ve, activated/memory and effector/memory Tcells) and metabolic (glycemia, insulin and HOMA-IR) parameters, in accord withprevious observations that centenarians have a peculiar immune profile, apreserved insulin pathway and a lower incidence of type 2 diabetes; and iii.unexpectedly, parameters related to frailty, as well as functional and cognitive status, did not show any significant correlation with the immune clustering,despite being capable per se of predicting survival. In conclusion, high valuesof basic immunological parameters and important T cell subsets correlate withfive-year survival in centenarians, independent of other phenotypiccharacteristics. This unexpected biological scenario is compatible with thegeneral hypothesis that in centenarians a progressive disconnection and loss ofbiological coherence among the different functions of the body occur, wheresurvival/mortality result from the failure of any of these domains whichapparently follow an independent age-related trajectory.
|Numero di pagine||7|
|Stato di pubblicazione||Published - 2014|